Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087173844> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2087173844 endingPage "944" @default.
- W2087173844 startingPage "941" @default.
- W2087173844 abstract "The ability of synthetic alpha-human atrial natriuretic polypeptide-(1-28) (alpha hANP) to alter steroidogenesis by human adrenal glands was investigated in primary human adrenal cell cultures. alphahANP (10(-9)-10(-7) M) inhibited basal and ACTH (10(-8) M)-stimulated aldosterone, cortisol, and dehydroepiandrosterone (DHEA) secretion in a dose-dependent manner. alpha hANP inhibited aldosterone (IC50, 1.3 X 10(-8) M) and cortisol (IC50, 0.7 X 10(-8) M) secretion more potently than it did DHEA (IC50, 7.5 X 10(-8) M) secretion. ACTH dose-dependent (10(-10)-10(-8) M) increases in aldosterone, cortisol, and DHEA secretion were significantly inhibited by alpha hANP (10(-8) M). In addition, alpha hANP enhanced the accumulation of intracellular cGMP in a dose-dependent manner. As aldosterone, cortisol, and DHEA secretion from cultured human adrenal cells was inhibited by alpha hANP, the site of inhibition of steroidogenesis by alpha hANP is probably localized in the early pathway of steroidogenesis in human adrenal cells. The results also suggest a link between inhibitory effects of alpha hANP and accumulation of intracellular cGMP." @default.
- W2087173844 created "2016-06-24" @default.
- W2087173844 creator A5001062336 @default.
- W2087173844 creator A5008266035 @default.
- W2087173844 creator A5051815236 @default.
- W2087173844 creator A5077665206 @default.
- W2087173844 creator A5082846066 @default.
- W2087173844 date "1986-05-01" @default.
- W2087173844 modified "2023-10-15" @default.
- W2087173844 title "α-Human Artial Natriuretic Polypeptide Inhibits Steroidogenesis in Cultured Human Adrenal Cells*" @default.
- W2087173844 doi "https://doi.org/10.1210/jcem-62-5-941" @default.
- W2087173844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3007561" @default.
- W2087173844 hasPublicationYear "1986" @default.
- W2087173844 type Work @default.
- W2087173844 sameAs 2087173844 @default.
- W2087173844 citedByCount "62" @default.
- W2087173844 crossrefType "journal-article" @default.
- W2087173844 hasAuthorship W2087173844A5001062336 @default.
- W2087173844 hasAuthorship W2087173844A5008266035 @default.
- W2087173844 hasAuthorship W2087173844A5051815236 @default.
- W2087173844 hasAuthorship W2087173844A5077665206 @default.
- W2087173844 hasAuthorship W2087173844A5082846066 @default.
- W2087173844 hasConcept C126322002 @default.
- W2087173844 hasConcept C134018914 @default.
- W2087173844 hasConcept C159110408 @default.
- W2087173844 hasConcept C185592680 @default.
- W2087173844 hasConcept C2775944032 @default.
- W2087173844 hasConcept C2776992908 @default.
- W2087173844 hasConcept C2777911890 @default.
- W2087173844 hasConcept C2777977426 @default.
- W2087173844 hasConcept C2778525890 @default.
- W2087173844 hasConcept C49039625 @default.
- W2087173844 hasConcept C49453240 @default.
- W2087173844 hasConcept C55493867 @default.
- W2087173844 hasConcept C64943373 @default.
- W2087173844 hasConcept C71315377 @default.
- W2087173844 hasConcept C71924100 @default.
- W2087173844 hasConcept C79879829 @default.
- W2087173844 hasConcept C86803240 @default.
- W2087173844 hasConceptScore W2087173844C126322002 @default.
- W2087173844 hasConceptScore W2087173844C134018914 @default.
- W2087173844 hasConceptScore W2087173844C159110408 @default.
- W2087173844 hasConceptScore W2087173844C185592680 @default.
- W2087173844 hasConceptScore W2087173844C2775944032 @default.
- W2087173844 hasConceptScore W2087173844C2776992908 @default.
- W2087173844 hasConceptScore W2087173844C2777911890 @default.
- W2087173844 hasConceptScore W2087173844C2777977426 @default.
- W2087173844 hasConceptScore W2087173844C2778525890 @default.
- W2087173844 hasConceptScore W2087173844C49039625 @default.
- W2087173844 hasConceptScore W2087173844C49453240 @default.
- W2087173844 hasConceptScore W2087173844C55493867 @default.
- W2087173844 hasConceptScore W2087173844C64943373 @default.
- W2087173844 hasConceptScore W2087173844C71315377 @default.
- W2087173844 hasConceptScore W2087173844C71924100 @default.
- W2087173844 hasConceptScore W2087173844C79879829 @default.
- W2087173844 hasConceptScore W2087173844C86803240 @default.
- W2087173844 hasIssue "5" @default.
- W2087173844 hasLocation W20871738441 @default.
- W2087173844 hasLocation W20871738442 @default.
- W2087173844 hasOpenAccess W2087173844 @default.
- W2087173844 hasPrimaryLocation W20871738441 @default.
- W2087173844 hasRelatedWork W1027088072 @default.
- W2087173844 hasRelatedWork W1964001371 @default.
- W2087173844 hasRelatedWork W1985643404 @default.
- W2087173844 hasRelatedWork W1993437498 @default.
- W2087173844 hasRelatedWork W2023063360 @default.
- W2087173844 hasRelatedWork W2070437032 @default.
- W2087173844 hasRelatedWork W2096111588 @default.
- W2087173844 hasRelatedWork W2115940959 @default.
- W2087173844 hasRelatedWork W2422993874 @default.
- W2087173844 hasRelatedWork W2888157337 @default.
- W2087173844 hasVolume "62" @default.
- W2087173844 isParatext "false" @default.
- W2087173844 isRetracted "false" @default.
- W2087173844 magId "2087173844" @default.
- W2087173844 workType "article" @default.