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• W2087190872 abstract "To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS).Randomized placebo-controlled study.Academic tertiary care medical center.Thirty insulin-resistant PCOS patients.Sixteen weeks of pioglitazone (30 mg/day) or placebo treatment.Twenty-four-hour 20 min integrated blood sampling for measurement of cortisol and 24 h urinary excretion of steroid metabolites. Relative 5alpha-reductase activity was evaluated by allotetrahydrocortisol (alloTHF)/THF and androsterone/etiocholanolone (A/E) ratios. Delta values denoted changes during the treatment period (16 weeks--basal). Pyridostigmine growth hormone (GH) stimulation tests were performed, and testosterone (T), dihydrotestosterone (DHT), DHEA, DHEAS, adiponectin, and insulin-like growth factor I (IGF-I) were measured before and after intervention.Insulin sensitivity, GH, adiponectin, and IGF-I significantly increased during pioglitazone treatment, whereas alloTHF/THF levels significantly decreased. Delta alloTHF/THF levels inversely correlated with Delta adiponectin levels. Delta A/E ratio inversely correlated with Delta IGF-I and Delta peak GH during GH stimulation tests. No significant changes were measured in T, DHT, DHEA, DHEAS, 24 h mean cortisol, or urinary excretion of steroid metabolites.Pioglitazone decreased relative 5alpha-reductase activity, whereas no significant changes were measured in cortisol levels or urinary cortisol excretion." @default.
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• W2087190872 date "2009-03-01" @default.
• W2087190872 modified "2023-10-10" @default.
• W2087190872 title "A randomized placebo-controlled study on the effects of pioglitazone on cortisol metabolism in polycystic ovary syndrome" @default.
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• W2087190872 doi "https://doi.org/10.1016/j.fertnstert.2007.12.082" @default.
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