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- W2087194957 abstract "Previous studies have indicated that the alkylating agent, 2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl] aminopropylamino)acridine dihydrochloride (ICR-170), induces much more killing and mutation in conidia of Neurospora crassa treated in an atmosphere of N2 than in an atmosphere of O2. It was desirable to determine if a similar effect—more killing and mutation in N2 than in O2—could be observed with two other known alkylating agents, β-propiolactone (BPL) and ethyl methane-sulfonate (EMS), in the same test system. Conidia of a heterokaryotic strain of N. crassa were bubbled with N2 or O2 during treatment with BPL or EMS. Forward-mutation was measured in the ad-3 region by a direct method. The results indicate that N2 or O2 do not influence the lethal and mutagenic activities of BPL or EMS during treatment of conodia. Hence the influence of N2 or O2 on the lethal and mutagenic activities of ICR-170 is different from the influence of these gases on BPL or EMS using the ad-3 test system in N. crassa." @default.
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- W2087194957 date "1961-12-01" @default.
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- W2087194957 title "On the radiomimetic effect of adenine in Vicia faba" @default.
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- W2087194957 doi "https://doi.org/10.1016/0014-4827(61)90201-4" @default.
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