FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087202996> ?p ?o ?g. }

• W2087202996 endingPage "54" @default.
• W2087202996 startingPage "46" @default.
• W2087202996 abstract "In previous studies, we have shown that overexpression of growth hormone (GH) in cells of the immune system upregulates proteins involved in cell growth and protects from apoptosis. Here, we report that overexpression of GH in EL4 T lymphoma cells (GHo) also significantly increased levels of the inhibitor of differentiation-2 (Id2). The increase in Id2 was suggested in both Id2 promoter luciferase assays and by Western analysis for Id2 protein. To identify the regulatory elements that mediate transcriptional activation by GH in the Id2 promoter, promoter deletion analysis was performed. Deletion analysis revealed that transactivation involved a 301-132bp region upstream to the Id2 transcriptional start site. The pattern in the human GHo Jurkat T lymphoma cell line paralleled that found in the mouse GHo EL4 T lymphoma cell line. Significantly less Id2 was detected in the nucleus of GHo EL4 T lymphoma cells compared to vector alone controls. Although serum increased the levels of Id2 in control vector alone cells, no difference was found in the total levels of Id2 in GHo EL4 T lymphoma cells treated with or without serum. The increase in Id2 expression in GHo EL4 T lymphoma cells measured by Id2 promoter luciferase expression and Western blot analysis was blocked by the overexpression of a dominant-negative mutant of STAT5. The results suggest that in EL4 T lymphoma cells overexpressing GH, there is an upregulation of Id2 protein that appears to involve STAT protein activity." @default.
• W2087202996 created "2016-06-24" @default.
• W2087202996 creator A5037128674 @default.
• W2087202996 date "2009-01-01" @default.
• W2087202996 modified "2023-09-25" @default.
• W2087202996 title "Regulation of Id2 expression in EL4 T lymphoma cells overexpressing growth hormone" @default.
• W2087202996 cites W1486014609 @default.
• W2087202996 cites W1491356095 @default.
• W2087202996 cites W1505072532 @default.
• W2087202996 cites W1509182464 @default.
• W2087202996 cites W1522139704 @default.
• W2087202996 cites W1532891194 @default.
• W2087202996 cites W1562190035 @default.
• W2087202996 cites W1579102917 @default.
• W2087202996 cites W1622668755 @default.
• W2087202996 cites W1748935412 @default.
• W2087202996 cites W1784996751 @default.
• W2087202996 cites W1801562323 @default.
• W2087202996 cites W1970392463 @default.
• W2087202996 cites W1971963400 @default.
• W2087202996 cites W1975337300 @default.
• W2087202996 cites W1976909977 @default.
• W2087202996 cites W1979269012 @default.
• W2087202996 cites W1980215718 @default.
• W2087202996 cites W1980445945 @default.
• W2087202996 cites W1981743414 @default.
• W2087202996 cites W1988719795 @default.
• W2087202996 cites W1999053969 @default.
• W2087202996 cites W1999184005 @default.
• W2087202996 cites W2000536319 @default.
• W2087202996 cites W2006438162 @default.
• W2087202996 cites W2010936295 @default.
• W2087202996 cites W2012711566 @default.
• W2087202996 cites W2013792925 @default.
• W2087202996 cites W2014732948 @default.
• W2087202996 cites W2017179498 @default.
• W2087202996 cites W2019277645 @default.
• W2087202996 cites W2031980124 @default.
• W2087202996 cites W2033569674 @default.
• W2087202996 cites W2035985790 @default.
• W2087202996 cites W2036518710 @default.
• W2087202996 cites W2036861892 @default.
• W2087202996 cites W2041401980 @default.
• W2087202996 cites W2042923460 @default.
• W2087202996 cites W2043364678 @default.
• W2087202996 cites W2044082708 @default.
• W2087202996 cites W2054879758 @default.
• W2087202996 cites W2060721330 @default.
• W2087202996 cites W2061630091 @default.
• W2087202996 cites W2064563703 @default.
• W2087202996 cites W2065733932 @default.
• W2087202996 cites W2074745312 @default.
• W2087202996 cites W2075490624 @default.
• W2087202996 cites W2076306570 @default.
• W2087202996 cites W2091582623 @default.
• W2087202996 cites W2099864318 @default.
• W2087202996 cites W2109663412 @default.
• W2087202996 cites W2111834601 @default.
• W2087202996 cites W2119483052 @default.
• W2087202996 cites W2122913401 @default.
• W2087202996 cites W2125164793 @default.
• W2087202996 cites W2126312929 @default.
• W2087202996 cites W2126846584 @default.
• W2087202996 cites W2159511823 @default.
• W2087202996 cites W2313306371 @default.
• W2087202996 cites W2414372705 @default.
• W2087202996 cites W4294294088 @default.
• W2087202996 cites W2012416297 @default.
• W2087202996 doi "https://doi.org/10.1016/j.cellimm.2008.10.003" @default.
• W2087202996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19010462" @default.
• W2087202996 hasPublicationYear "2009" @default.
• W2087202996 type Work @default.
• W2087202996 sameAs 2087202996 @default.
• W2087202996 citedByCount "6" @default.
• W2087202996 countsByYear W20872029962013 @default.
• W2087202996 countsByYear W20872029962016 @default.
• W2087202996 countsByYear W20872029962019 @default.
• W2087202996 crossrefType "journal-article" @default.
• W2087202996 hasAuthorship W2087202996A5037128674 @default.
• W2087202996 hasConcept C104317684 @default.
• W2087202996 hasConcept C127561419 @default.
• W2087202996 hasConcept C1292079 @default.
• W2087202996 hasConcept C150194340 @default.
• W2087202996 hasConcept C153911025 @default.
• W2087202996 hasConcept C179464577 @default.
• W2087202996 hasConcept C190283241 @default.
• W2087202996 hasConcept C203014093 @default.
• W2087202996 hasConcept C27153228 @default.
• W2087202996 hasConcept C2776090121 @default.
• W2087202996 hasConcept C2776415932 @default.
• W2087202996 hasConcept C2779338263 @default.
• W2087202996 hasConcept C29537977 @default.
• W2087202996 hasConcept C502942594 @default.
• W2087202996 hasConcept C54355233 @default.
• W2087202996 hasConcept C81885089 @default.
• W2087202996 hasConcept C86803240 @default.
• W2087202996 hasConcept C8891405 @default.
• W2087202996 hasConceptScore W2087202996C104317684 @default.

• next