FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087207926> ?p ?o ?g. }

• W2087207926 endingPage "375" @default.
• W2087207926 startingPage "368" @default.
• W2087207926 abstract "We have synthesized the principal advances in the field of the study of epigenetics and specifically DNA methylation regarding the diagnosis of urological neoplasms.Review of the literature (PubMed, MEDLINE and Cochrane) on the study of DNA methylation in urological neoplasms (prostate cancer, bladder cancer, renal cancer and testicular cancer), considering all the studies published up to January 2013.It was possible to determine the state of methylation of many genes in our tumor samples. When these were compared with healthy tissue samples, it was possible to define the specific aberrant methylation patterns for each type of tumor. The study and definition of specific abnormal methylation patterns of each type of tumor is a tool having potential utility for diagnosis, evaluation, prediction of prognosis and treatment of the different forms of genitourinary cancer. The analysis of gene methylation in urine after micturition or post-prostatic massage urine, semen, in the wash plasma or fluid from prostatic biopsies may allow early detection of bladder, prostate, renal and testicular cancer. In each one of the neoplasms, an epigenetic signature that may be detected in the DNA has been identified, obtained from very scarce or not at all invasive specimens, with potential in the diagnosis and evaluation of prognosis. Validation of these studies will confirm the accuracy, effectiveness and reproducibility of the results available up to now. Criteria have still not been developed that determine if a gene panel provides sufficient information in the health care practice to guide an unequivocal diagnosis or therapeutic conduct. More studies are needed to compare sensitivity, specificity, positive and negative predictive value of the test in each case. Multicenter studies analyzing the real reproducibility of these results in a clinical setting also do not exist.The study of aberrant DNA methylation in biological specimens of patients has an enormous potential for the early diagnosis and screening of genitourinary neoplasms. A larger number of studies is needed to be able to define the series of genes that would mean unequivocal signatures of malignancy. This methodology also has potential when defining prognostic groups and potential of response to different therapies." @default.
• W2087207926 created "2016-06-24" @default.
• W2087207926 creator A5012922484 @default.
• W2087207926 creator A5066051519 @default.
• W2087207926 creator A5068392384 @default.
• W2087207926 creator A5077053703 @default.
• W2087207926 creator A5089439116 @default.
• W2087207926 date "2013-06-01" @default.
• W2087207926 modified "2023-09-25" @default.
• W2087207926 title "El estudio de la metilación del ADN en el cáncer urológico: presente y futuro" @default.
• W2087207926 cites W1489006980 @default.
• W2087207926 cites W1541220856 @default.
• W2087207926 cites W1586730439 @default.
• W2087207926 cites W1658127082 @default.
• W2087207926 cites W1761825801 @default.
• W2087207926 cites W179317932 @default.
• W2087207926 cites W1912311013 @default.
• W2087207926 cites W1927817663 @default.
• W2087207926 cites W1965262464 @default.
• W2087207926 cites W1975279481 @default.
• W2087207926 cites W1979273476 @default.
• W2087207926 cites W1981989535 @default.
• W2087207926 cites W1983181666 @default.
• W2087207926 cites W1994254820 @default.
• W2087207926 cites W1994465394 @default.
• W2087207926 cites W2002045993 @default.
• W2087207926 cites W2004172747 @default.
• W2087207926 cites W2009052021 @default.
• W2087207926 cites W2022957119 @default.
• W2087207926 cites W2029197798 @default.
• W2087207926 cites W2036986058 @default.
• W2087207926 cites W2060570548 @default.
• W2087207926 cites W2061576586 @default.
• W2087207926 cites W2061611574 @default.
• W2087207926 cites W2071642351 @default.
• W2087207926 cites W2078751312 @default.
• W2087207926 cites W2089430790 @default.
• W2087207926 cites W2094159831 @default.
• W2087207926 cites W2096278234 @default.
• W2087207926 cites W2096330673 @default.
• W2087207926 cites W2101995865 @default.
• W2087207926 cites W2111107512 @default.
• W2087207926 cites W2117261377 @default.
• W2087207926 cites W2129604622 @default.
• W2087207926 cites W2132180848 @default.
• W2087207926 cites W2134142571 @default.
• W2087207926 cites W2137521223 @default.
• W2087207926 cites W2140433786 @default.
• W2087207926 cites W2144823751 @default.
• W2087207926 cites W2147511945 @default.
• W2087207926 cites W2149199597 @default.
• W2087207926 cites W2150162153 @default.
• W2087207926 cites W2151754569 @default.
• W2087207926 cites W2153680571 @default.
• W2087207926 cites W2158985838 @default.
• W2087207926 cites W2162813066 @default.
• W2087207926 doi "https://doi.org/10.1016/j.acuro.2013.03.001" @default.
• W2087207926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23643196" @default.
• W2087207926 hasPublicationYear "2013" @default.
• W2087207926 type Work @default.
• W2087207926 sameAs 2087207926 @default.
• W2087207926 citedByCount "15" @default.
• W2087207926 countsByYear W20872079262013 @default.
• W2087207926 countsByYear W20872079262014 @default.
• W2087207926 countsByYear W20872079262015 @default.
• W2087207926 countsByYear W20872079262016 @default.
• W2087207926 countsByYear W20872079262017 @default.
• W2087207926 countsByYear W20872079262018 @default.
• W2087207926 countsByYear W20872079262019 @default.
• W2087207926 countsByYear W20872079262021 @default.
• W2087207926 crossrefType "journal-article" @default.
• W2087207926 hasAuthorship W2087207926A5012922484 @default.
• W2087207926 hasAuthorship W2087207926A5066051519 @default.
• W2087207926 hasAuthorship W2087207926A5068392384 @default.
• W2087207926 hasAuthorship W2087207926A5077053703 @default.
• W2087207926 hasAuthorship W2087207926A5089439116 @default.
• W2087207926 hasConcept C104317684 @default.
• W2087207926 hasConcept C121608353 @default.
• W2087207926 hasConcept C126322002 @default.
• W2087207926 hasConcept C133507102 @default.
• W2087207926 hasConcept C142724271 @default.
• W2087207926 hasConcept C143998085 @default.
• W2087207926 hasConcept C150194340 @default.
• W2087207926 hasConcept C190727270 @default.
• W2087207926 hasConcept C2776212926 @default.
• W2087207926 hasConcept C2776235491 @default.
• W2087207926 hasConcept C2780192828 @default.
• W2087207926 hasConcept C2780352672 @default.
• W2087207926 hasConcept C29456083 @default.
• W2087207926 hasConcept C33288867 @default.
• W2087207926 hasConcept C41091548 @default.
• W2087207926 hasConcept C55493867 @default.
• W2087207926 hasConcept C71924100 @default.
• W2087207926 hasConcept C86803240 @default.
• W2087207926 hasConceptScore W2087207926C104317684 @default.
• W2087207926 hasConceptScore W2087207926C121608353 @default.
• W2087207926 hasConceptScore W2087207926C126322002 @default.
• W2087207926 hasConceptScore W2087207926C133507102 @default.

• next