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- W2087208032 abstract "Thymic interleukin-6 (IL-6), which is produced primarily by thymic epithelial cells, is an important cytokine for T cell growth and differentiation in the thymus. In the present study, we investigated the effects of autocrine IL-6 on the cytokines in primary cultures of human thymic epithelial cells. Using an antibody array and ELISA, in addition to IL-8 and MCP-1, growth-related oncogene-alpha (GRO-alpha) was subsequently expressed after IL-6 production. Either IL-6 or GRO-alpha was time-dependently and strongly expressed in medium with and without serum. Neutralizing IL-6 significantly reduced GRO-alpha production. Inhibiting Janus kinase 2 (Jak2) spontaneously blocked GRO-alpha production with or without IL-6 stimulation. We conclude that primary human thymic epithelial cells produce GRO-alpha and that its expression is regulated primarily by autocrine IL-6 and IL-6-activated Jak2 signaling." @default.
- W2087208032 created "2016-06-24" @default.
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- W2087208032 date "2010-08-01" @default.
- W2087208032 modified "2023-10-07" @default.
- W2087208032 title "Autocrine IL-6 regulates GRO-α production in thymic epithelial cells" @default.
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- W2087208032 doi "https://doi.org/10.1016/j.cyto.2010.05.002" @default.
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