Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087211433> ?p ?o ?g. }
- W2087211433 abstract "Total radiation dose often can be increased without subsequent increases in the severity of tissue injury by using reduced doses per fraction. The flexure dose, df, is defined as the largest fractional dose for which further fractionation produces no significant change in the total dose required to reach a specified effect level. Thus, df is clinically relevant in that it represents the limit of effective dose fractionation. For those tissues in which injury reflects depletion of a critical proportion of target cells, the flexure dose is a measure of the extent of the initial, nearly linear portion of the dose-survival curve. More generally, the flexure dose is a measure of the extent of the initial, nearly linear portion of a dose-response curve in organized tissue, whatever its relationship to clonogenic target cells might be. Several quantitative expressions for df are derived. The characteristic common to these is that each defines the flexure dose as a multiple of the ratio alpha/beta of the parameters of the linear-quadratic model of cell survival or dose response, where the multiple is a measure of experimental or statistical resolution. These multiples tend to fall within a limited range, thereby defining the region of flexure via the inequality 0.05 (alpha/beta) less than or equal to df less than or equal to 0.15 (alpha/beta). Estimates of the region of flexure are presented for a variety of normal and neoplastic tissues." @default.
- W2087211433 created "2016-06-24" @default.
- W2087211433 creator A5070431570 @default.
- W2087211433 creator A5085700191 @default.
- W2087211433 date "1983-09-01" @default.
- W2087211433 modified "2023-09-25" @default.
- W2087211433 title "Flexure dose: The low-dose limit of effective fractionation" @default.
- W2087211433 cites W1500823836 @default.
- W2087211433 cites W1964574871 @default.
- W2087211433 cites W1965631961 @default.
- W2087211433 cites W1965785271 @default.
- W2087211433 cites W1966440390 @default.
- W2087211433 cites W1967214473 @default.
- W2087211433 cites W1967697595 @default.
- W2087211433 cites W1969126224 @default.
- W2087211433 cites W1977043170 @default.
- W2087211433 cites W1986678401 @default.
- W2087211433 cites W1988024604 @default.
- W2087211433 cites W1991536033 @default.
- W2087211433 cites W2010716171 @default.
- W2087211433 cites W2016871222 @default.
- W2087211433 cites W2022998219 @default.
- W2087211433 cites W2027249461 @default.
- W2087211433 cites W2029369950 @default.
- W2087211433 cites W2034562813 @default.
- W2087211433 cites W2054320650 @default.
- W2087211433 cites W2055221631 @default.
- W2087211433 cites W2068468188 @default.
- W2087211433 cites W2070208744 @default.
- W2087211433 cites W2070735189 @default.
- W2087211433 cites W2086404173 @default.
- W2087211433 cites W2091216435 @default.
- W2087211433 cites W2094691753 @default.
- W2087211433 cites W2111685034 @default.
- W2087211433 cites W2113709744 @default.
- W2087211433 cites W2136594231 @default.
- W2087211433 cites W2333519617 @default.
- W2087211433 cites W249314684 @default.
- W2087211433 cites W2626425857 @default.
- W2087211433 cites W365372026 @default.
- W2087211433 cites W2071071043 @default.
- W2087211433 doi "https://doi.org/10.1016/0360-3016(83)90270-5" @default.
- W2087211433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6885550" @default.
- W2087211433 hasPublicationYear "1983" @default.
- W2087211433 type Work @default.
- W2087211433 sameAs 2087211433 @default.
- W2087211433 citedByCount "43" @default.
- W2087211433 crossrefType "journal-article" @default.
- W2087211433 hasAuthorship W2087211433A5070431570 @default.
- W2087211433 hasAuthorship W2087211433A5085700191 @default.
- W2087211433 hasConcept C117262875 @default.
- W2087211433 hasConcept C120665830 @default.
- W2087211433 hasConcept C121332964 @default.
- W2087211433 hasConcept C126322002 @default.
- W2087211433 hasConcept C134306372 @default.
- W2087211433 hasConcept C141071460 @default.
- W2087211433 hasConcept C151201525 @default.
- W2087211433 hasConcept C153385146 @default.
- W2087211433 hasConcept C185592680 @default.
- W2087211433 hasConcept C199360897 @default.
- W2087211433 hasConcept C202751555 @default.
- W2087211433 hasConcept C2775944032 @default.
- W2087211433 hasConcept C2776174256 @default.
- W2087211433 hasConcept C2989005 @default.
- W2087211433 hasConcept C33923547 @default.
- W2087211433 hasConcept C41008148 @default.
- W2087211433 hasConcept C43617362 @default.
- W2087211433 hasConcept C49453240 @default.
- W2087211433 hasConcept C55493867 @default.
- W2087211433 hasConcept C64943373 @default.
- W2087211433 hasConcept C71924100 @default.
- W2087211433 hasConcept C79410662 @default.
- W2087211433 hasConcept C86803240 @default.
- W2087211433 hasConcept C97428945 @default.
- W2087211433 hasConceptScore W2087211433C117262875 @default.
- W2087211433 hasConceptScore W2087211433C120665830 @default.
- W2087211433 hasConceptScore W2087211433C121332964 @default.
- W2087211433 hasConceptScore W2087211433C126322002 @default.
- W2087211433 hasConceptScore W2087211433C134306372 @default.
- W2087211433 hasConceptScore W2087211433C141071460 @default.
- W2087211433 hasConceptScore W2087211433C151201525 @default.
- W2087211433 hasConceptScore W2087211433C153385146 @default.
- W2087211433 hasConceptScore W2087211433C185592680 @default.
- W2087211433 hasConceptScore W2087211433C199360897 @default.
- W2087211433 hasConceptScore W2087211433C202751555 @default.
- W2087211433 hasConceptScore W2087211433C2775944032 @default.
- W2087211433 hasConceptScore W2087211433C2776174256 @default.
- W2087211433 hasConceptScore W2087211433C2989005 @default.
- W2087211433 hasConceptScore W2087211433C33923547 @default.
- W2087211433 hasConceptScore W2087211433C41008148 @default.
- W2087211433 hasConceptScore W2087211433C43617362 @default.
- W2087211433 hasConceptScore W2087211433C49453240 @default.
- W2087211433 hasConceptScore W2087211433C55493867 @default.
- W2087211433 hasConceptScore W2087211433C64943373 @default.
- W2087211433 hasConceptScore W2087211433C71924100 @default.
- W2087211433 hasConceptScore W2087211433C79410662 @default.
- W2087211433 hasConceptScore W2087211433C86803240 @default.
- W2087211433 hasConceptScore W2087211433C97428945 @default.
- W2087211433 hasLocation W20872114331 @default.
- W2087211433 hasLocation W20872114332 @default.