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- W2087222774 abstract "Abstract In Xenopus , activin‐like signals are able to induce and pattern mesoderm in a concentration‐dependent manner. Previous experiments demonstrated that discrete gene expression patterns can be formed in animal cap explants as a response to graded activin signals. We analyzed the spatiotemporal appearance of goosecoid ( gsc ), chordin ( chd ), and Xbrachyury ( Xbra ) mRNAs in whole Xenopus embryos ectopically expressing activin or BVg1. To discriminate between direct transcriptional regulation and indirect, protein synthesis‐dependent effects of ectopic signals, we combined overexpression studies and cycloheximide treatment. Our experiments revealed long‐range signaling of activin/BVg1, but the expression patterns of gsc , chd , and Xbra in response to activin/BVg1 indicated that repressors are essential to establish the proper expression of these genes. Analysis of endogenous gsc , chd , and Xbra transcript distribution in embryos treated with cycloheximide supported this concept. We, therefore, conclude that inhibition is fundamental during early embryonic patterning. Developmental Dynamics 233:418–429, 2005. © 2005 Wiley‐Liss, Inc." @default.
- W2087222774 created "2016-06-24" @default.
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- W2087222774 date "2005-03-18" @default.
- W2087222774 modified "2023-09-23" @default.
- W2087222774 title "Establishment of mesodermal gene expression patterns in earlyXenopus embryos: The role of repression" @default.
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- W2087222774 doi "https://doi.org/10.1002/dvdy.20342" @default.
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