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• W2087224142 abstract "Mycobacteria elicit two quite different immune responses. One is protective and is partly based on recognition and lysis of stressed, bacilli-laden cells expressing heat-shock proteins. The other suppresses this recognition and instead leads to indiscriminate necrosis of tissues containing mycobacteria (the Koch phenomenon). The type of response depends on the predominant T-cell maturation pathway, Th1 or Th2, which in turn is determined by priming by prior contact with environmental mycobacteria. Vaccination by BCG induces whichever response the recipient is primed to make, and this is a likely explanation of the variable efficacy of this vaccine in prevention of tuberculosis and therapy of cancer. Thus, BCG is a two-edged sword. We postulate that by using other mycobacterial preparations, such as killed Mycobacterium vaccae, it might be possible to suppress the indiscriminate necrosis and enhance Th1-regulated selective destruction of tumour cells." @default.
• W2087224142 created "2016-06-24" @default.
• W2087224142 creator A5004437067 @default.
• W2087224142 date "1991-12-01" @default.
• W2087224142 modified "2023-09-27" @default.
• W2087224142 title "Koch's phenomenon: can it be corrected?" @default.
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• W2087224142 doi "https://doi.org/10.1016/0041-3879(91)90047-v" @default.
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