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- W2087235073 abstract "Objective: To investigate the relationships between the rs4149601 polymorphisms of neural precursor cell expressed developmentally downregulated 4-like gene (NEDD4L) and obesity in Kazakh. Methods: By genotyping the rs4149601 polymorphisms in a Kazakh general population (856 subjects, aged 30 to 60 years), a case–control study was conducted. Results: This polymorphism was successfully genotyped in 853 Kazakh subjects. The distribution of the additive model and dominant model (A/G+A/A vs G/G) of rs4149601 polymorphisms differed significantly between case and control in total and female (all P<0.05). After adjusting for confounding factors, logistic regression analysis showed that rs4149601 polymorphisms (in dominant model) was significantly associated with obesity (OR=1.479, 95% CI: 1.103–1.983, P=0.009) in Kazakh. Covariate variance analysis showed that compared with subjects with A/A+A/G genotype, the mean of waist circumference was significantly higher in subjects with G/G genotype in Kazakh after adjusting for age, smoking and drinking (P=0.028). Conclusions: The genetic variations of NEDD4L may be associated with obesity in Kazakh general population." @default.
- W2087235073 created "2016-06-24" @default.
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- W2087235073 date "2011-10-01" @default.
- W2087235073 modified "2023-09-25" @default.
- W2087235073 title "The rs4149601 polymorphism of NEDD4L gene is associated with obesity Kazakh general population in Xinjiang" @default.
- W2087235073 doi "https://doi.org/10.1016/j.ijcard.2011.08.758" @default.
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