FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087246620> ?p ?o ?g. }

• W2087246620 endingPage "2393" @default.
• W2087246620 startingPage "2387" @default.
• W2087246620 abstract "To treat cancer cells overexpressing P-glycoprotein (P-gp), we propose a new concept using a nanodrug. The nanodrug was prepared from polyethyleneimine (PEI)/all-trans retinoic acid (ATRA) conjugates (PRA) and covered with hyaluronic acid (HA) to control the cytotoxicity of PRA (yielding PRA-H). The size distribution of PRA-H was narrow, with an average particle size of approximately 143 nm. Its superior stability in phosphate-buffered saline (PBS) was verified by monitoring changes in particle size and zeta potential for 24 h, which were negligible. In contrast, PEI-H (not conjugated with ATRA) exhibited a significant change in particle size and zeta potential. Although PRA was highly cytotoxic against HCT-8 and SNU-484 cancer cells, both of which overexpress P-gp, the cytotoxicity was significantly reduced by shielding with HA. The cytotoxicity of PRA-H was recovered by treatment with hyaluronidase (HAase), which degrades HA and is present in tumors at high concentrations. These results were confirmed by optical microscopy, fluorescence-activated cell sorting (FACs) analysis, and confocal microscopy. The cytotoxic mechanism of PRA was revealed as a type of necrotic lysis by FACs analysis with propidium iodide (PI) staining. Furthermore, PRA increased HCT-8 cell (colon cancer) permeability to doxorubicin (DOX). Therefore, we concluded that PRA-H is a promising new candidate for the treatment of cells with multidrug resistance (MDR) induced by overexpression of P-gp and cancer stem cells." @default.
• W2087246620 created "2016-06-24" @default.
• W2087246620 creator A5067328906 @default.
• W2087246620 creator A5090923792 @default.
• W2087246620 date "2010-08-05" @default.
• W2087246620 modified "2023-09-27" @default.
• W2087246620 title "Polycationic Nanodrug Covered with Hyaluronic Acid for Treatment of P-Glycoprotein Overexpressing Cancer Cells" @default.
• W2087246620 cites W1230936899 @default.
• W2087246620 cites W1587028183 @default.
• W2087246620 cites W1847528436 @default.
• W2087246620 cites W1914681647 @default.
• W2087246620 cites W1963649673 @default.
• W2087246620 cites W1965411743 @default.
• W2087246620 cites W1969497292 @default.
• W2087246620 cites W1979110040 @default.
• W2087246620 cites W1989310657 @default.
• W2087246620 cites W1999444272 @default.
• W2087246620 cites W2000136129 @default.
• W2087246620 cites W2006434892 @default.
• W2087246620 cites W2009793256 @default.
• W2087246620 cites W2010491698 @default.
• W2087246620 cites W2023520902 @default.
• W2087246620 cites W2027740621 @default.
• W2087246620 cites W2032025349 @default.
• W2087246620 cites W2043025200 @default.
• W2087246620 cites W2048573811 @default.
• W2087246620 cites W2049520769 @default.
• W2087246620 cites W2052948660 @default.
• W2087246620 cites W2061298493 @default.
• W2087246620 cites W2065792250 @default.
• W2087246620 cites W2072225623 @default.
• W2087246620 cites W2080343780 @default.
• W2087246620 cites W2081966932 @default.
• W2087246620 cites W2084837142 @default.
• W2087246620 cites W2087020662 @default.
• W2087246620 cites W2101621191 @default.
• W2087246620 cites W2107214690 @default.
• W2087246620 cites W2122872625 @default.
• W2087246620 cites W2133591717 @default.
• W2087246620 cites W2139441606 @default.
• W2087246620 cites W2147696493 @default.
• W2087246620 cites W2148053857 @default.
• W2087246620 cites W2150953709 @default.
• W2087246620 cites W2152504641 @default.
• W2087246620 cites W2153712534 @default.
• W2087246620 cites W2163294691 @default.
• W2087246620 doi "https://doi.org/10.1021/bm100562z" @default.
• W2087246620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20687538" @default.
• W2087246620 hasPublicationYear "2010" @default.
• W2087246620 type Work @default.
• W2087246620 sameAs 2087246620 @default.
• W2087246620 citedByCount "27" @default.
• W2087246620 countsByYear W20872466202013 @default.
• W2087246620 countsByYear W20872466202014 @default.
• W2087246620 countsByYear W20872466202015 @default.
• W2087246620 countsByYear W20872466202017 @default.
• W2087246620 countsByYear W20872466202018 @default.
• W2087246620 countsByYear W20872466202019 @default.
• W2087246620 countsByYear W20872466202021 @default.
• W2087246620 crossrefType "journal-article" @default.
• W2087246620 hasAuthorship W2087246620A5067328906 @default.
• W2087246620 hasAuthorship W2087246620A5090923792 @default.
• W2087246620 hasConcept C104317684 @default.
• W2087246620 hasConcept C109316439 @default.
• W2087246620 hasConcept C121608353 @default.
• W2087246620 hasConcept C153911025 @default.
• W2087246620 hasConcept C154317977 @default.
• W2087246620 hasConcept C185592680 @default.
• W2087246620 hasConcept C190283241 @default.
• W2087246620 hasConcept C202751555 @default.
• W2087246620 hasConcept C2775934118 @default.
• W2087246620 hasConcept C2776694085 @default.
• W2087246620 hasConcept C2777529286 @default.
• W2087246620 hasConcept C2781121885 @default.
• W2087246620 hasConcept C2781303535 @default.
• W2087246620 hasConcept C31573885 @default.
• W2087246620 hasConcept C54355233 @default.
• W2087246620 hasConcept C553184892 @default.
• W2087246620 hasConcept C55493867 @default.
• W2087246620 hasConcept C86803240 @default.
• W2087246620 hasConcept C96232424 @default.
• W2087246620 hasConceptScore W2087246620C104317684 @default.
• W2087246620 hasConceptScore W2087246620C109316439 @default.
• W2087246620 hasConceptScore W2087246620C121608353 @default.
• W2087246620 hasConceptScore W2087246620C153911025 @default.
• W2087246620 hasConceptScore W2087246620C154317977 @default.
• W2087246620 hasConceptScore W2087246620C185592680 @default.
• W2087246620 hasConceptScore W2087246620C190283241 @default.
• W2087246620 hasConceptScore W2087246620C202751555 @default.
• W2087246620 hasConceptScore W2087246620C2775934118 @default.
• W2087246620 hasConceptScore W2087246620C2776694085 @default.
• W2087246620 hasConceptScore W2087246620C2777529286 @default.
• W2087246620 hasConceptScore W2087246620C2781121885 @default.
• W2087246620 hasConceptScore W2087246620C2781303535 @default.
• W2087246620 hasConceptScore W2087246620C31573885 @default.
• W2087246620 hasConceptScore W2087246620C54355233 @default.
• W2087246620 hasConceptScore W2087246620C553184892 @default.
• W2087246620 hasConceptScore W2087246620C55493867 @default.

• next