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• W2087249096 abstract "Glutamatergic cortical and dopaminergic nigral afferents converge onto neurons of the neostriatum forming synapses in close proximity. Studies, mainly using pharmacological methods, suggest presynaptic interactions between these afferents. The influence of dopaminergic transmission on the cortical terminal fields in the striatum was assessed electrophysiologically using the terminal excitability method. Antidromic action potentials recorded from neurons in the prefrontal cortex were elicited by bipolar electrical stimulation (250 μm wire, 0.5 mm tip separation) of the cortical terminal field in the contralateral dorsomedial neostriatum. Threshold excitability was defined as the minimum current sufficient to elicit 95–100% antidromic response on non-collision trials. Under control conditions, the mean threshold current was 1.7 ± 0.2mA. Drugs were applied in a volume of 312 nl delivered over 5 min to the striatal stimulation site. Following local striatal administration of amphetamine (10 μM) or electrical stimulation of the nigrostriatal pathway (1–2 pulses, 1.5 mA/0.5 ms/1 Hz) an increase in striatal stimulating current was required in order to reinstate threshold levels of antidromic response. This decrease in the excitability of corticostriatal afferents cpuld be reversed by local infusion of haloperidol (1 μM) orl-sulpiride (10 nM) and did not occur following depletion of dopamine stores with α-methylparatyrosine and reserpine. The possible participation of postsynaptic dopamine receptor stimulation was ruled out as these effects were still seen in animals with kainic acid induced lesions of the striatum. In addition, terminal excitability was not modified by the muscarinic agonist carbachol (10 μM). Striatal administration of apomorphine (10 μM) decreased terminal excitability similar to amphetamine. The specific D-2 agonist, quinpirole (10–20 μM) did not affect excitability. These results indicate that manipulations which have been shown to increase the release of endogenous dopamine decrease the excitability of prefrontal corticostriatal afferents by stimulation of presynaptic dopamine receptors which are insensitive to low doses of quinpirole but sensitive tol-sulpiride and apomorphine. The mechanisms underlying dopamine-induced changes in terminal excitability are likely to be similar to those which have been shown to alter conductance at postsynaptic sites." @default.
• W2087249096 created "2016-06-24" @default.
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• W2087249096 date "1991-06-01" @default.
• W2087249096 modified "2023-10-16" @default.
• W2087249096 title "Terminal excitability of the corticostrial pathway. I. Regulation by dopamine receptor stimulation" @default.
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• W2087249096 cites W1970855023 @default.
• W2087249096 cites W1972053345 @default.
• W2087249096 cites W1972599491 @default.
• W2087249096 cites W1973512436 @default.
• W2087249096 cites W1979359907 @default.
• W2087249096 cites W1980016842 @default.
• W2087249096 cites W1982254637 @default.
• W2087249096 cites W1983961819 @default.
• W2087249096 cites W1991566731 @default.
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• W2087249096 cites W1995355257 @default.
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• W2087249096 cites W2002159489 @default.
• W2087249096 cites W2005235262 @default.
• W2087249096 cites W2005313097 @default.
• W2087249096 cites W2007064958 @default.
• W2087249096 cites W2008142526 @default.
• W2087249096 cites W2010299478 @default.
• W2087249096 cites W2011056571 @default.
• W2087249096 cites W2012059081 @default.
• W2087249096 cites W2014486882 @default.
• W2087249096 cites W2014568410 @default.
• W2087249096 cites W2024478624 @default.
• W2087249096 cites W2026306356 @default.
• W2087249096 cites W2026339353 @default.
• W2087249096 cites W2030683825 @default.
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• W2087249096 cites W2033426176 @default.
• W2087249096 cites W2036182292 @default.
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• W2087249096 cites W2039598676 @default.
• W2087249096 cites W2039732315 @default.
• W2087249096 cites W2041409139 @default.
• W2087249096 cites W2043393596 @default.
• W2087249096 cites W2045863504 @default.
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• W2087249096 cites W2060770514 @default.
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• W2087249096 cites W2063370969 @default.
• W2087249096 cites W2067319613 @default.
• W2087249096 cites W2069978126 @default.
• W2087249096 cites W2074657360 @default.
• W2087249096 cites W2084523150 @default.
• W2087249096 cites W2086345956 @default.
• W2087249096 cites W2088606259 @default.
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• W2087249096 doi "https://doi.org/10.1016/0006-8993(91)90933-m" @default.
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