Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087257572> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2087257572 endingPage "172" @default.
- W2087257572 startingPage "163" @default.
- W2087257572 abstract "Heaves is an allergic airway disease in horses characterised by reversible airway obstruction, bronchial hyperresponsiveness and airway inflammation associated with a Th(2) response. Cyclic nucleotide-dependent signalling pathways can regulate lymphocyte function. In this study, we examined lymphocyte PDE activity comparing horses with heaves to healthy control animals. Total PDE activity and the effects of isoenzyme selective inhibitors were measured before, 5 and 24 h after the start of a 7 h allergen challenge. Allergen challenge had no effect on either total cAMP PDE activity or its inhibition by the PDE4 selective inhibitor, rolipram, and the non-selective PDE inhibitor, theophylline. In contrast, the PDE3 selective inhibitor, quazinone, caused significantly greater inhibition of cAMP PDE activity before challenge in the heaves susceptible group. Additionally, total cGMP PDE activity was significantly lower 24 h after the start of challenge in the heaves affected group (11+/-2 and 21+/-3 pmol/min/mg for heaves and control animals, respectively) and the PDE5 selective inhibitor, zaprinast, caused significantly less inhibition in the heaves group at this time point. The functional significance of these findings was explored by examining the effect of PDE3, PDE4 and PDE5 selective inhibitors on mitogen-induced mononuclear cell proliferation before and 24 h after the start of allergen challenge. Proliferation decreased after challenge in the heaves group (stimulation index=328+/-110 and 200+/-72 before and after challenge, respectively) whilst remaining constant in the control group (stimulation index=161+/-13 and 183+/-45 before and after challenge, respectively). However, all three PDE inhibitors caused a similar amount of inhibition at each time point and the effect of a combination of a PDE3 and a PDE5 inhibitor was simply additive in both groups. These results suggest differences in the control of lymphocyte PDE activity in horses with heaves." @default.
- W2087257572 created "2016-06-24" @default.
- W2087257572 creator A5007575726 @default.
- W2087257572 creator A5048076038 @default.
- W2087257572 creator A5054982987 @default.
- W2087257572 date "2004-06-01" @default.
- W2087257572 modified "2023-10-06" @default.
- W2087257572 title "Allergen challenge alters lymphocyte phosphodiesterase activity in horses with heaves" @default.
- W2087257572 cites W1775749144 @default.
- W2087257572 cites W1967882515 @default.
- W2087257572 cites W1968226808 @default.
- W2087257572 cites W1973260205 @default.
- W2087257572 cites W1973519389 @default.
- W2087257572 cites W1974536864 @default.
- W2087257572 cites W1974825502 @default.
- W2087257572 cites W1976375287 @default.
- W2087257572 cites W1994248480 @default.
- W2087257572 cites W1996145424 @default.
- W2087257572 cites W2011569264 @default.
- W2087257572 cites W2016018338 @default.
- W2087257572 cites W2020199042 @default.
- W2087257572 cites W2022352561 @default.
- W2087257572 cites W2023430605 @default.
- W2087257572 cites W2031584475 @default.
- W2087257572 cites W2033788890 @default.
- W2087257572 cites W2034179761 @default.
- W2087257572 cites W2041385557 @default.
- W2087257572 cites W2047359372 @default.
- W2087257572 cites W2052819862 @default.
- W2087257572 cites W2057665954 @default.
- W2087257572 cites W2059822315 @default.
- W2087257572 cites W2063354518 @default.
- W2087257572 cites W2070399392 @default.
- W2087257572 cites W2074834459 @default.
- W2087257572 cites W2085338889 @default.
- W2087257572 cites W2086187705 @default.
- W2087257572 cites W2112667627 @default.
- W2087257572 cites W2117174491 @default.
- W2087257572 cites W2127790273 @default.
- W2087257572 cites W2131230648 @default.
- W2087257572 cites W2140775892 @default.
- W2087257572 cites W2148081236 @default.
- W2087257572 cites W2288346340 @default.
- W2087257572 cites W4251949468 @default.
- W2087257572 doi "https://doi.org/10.1016/j.pupt.2004.02.001" @default.
- W2087257572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15123226" @default.
- W2087257572 hasPublicationYear "2004" @default.
- W2087257572 type Work @default.
- W2087257572 sameAs 2087257572 @default.
- W2087257572 citedByCount "13" @default.
- W2087257572 countsByYear W20872575722012 @default.
- W2087257572 countsByYear W20872575722016 @default.
- W2087257572 crossrefType "journal-article" @default.
- W2087257572 hasAuthorship W2087257572A5007575726 @default.
- W2087257572 hasAuthorship W2087257572A5048076038 @default.
- W2087257572 hasAuthorship W2087257572A5054982987 @default.
- W2087257572 hasConcept C126322002 @default.
- W2087257572 hasConcept C181199279 @default.
- W2087257572 hasConcept C185592680 @default.
- W2087257572 hasConcept C203014093 @default.
- W2087257572 hasConcept C2776846068 @default.
- W2087257572 hasConcept C2776958096 @default.
- W2087257572 hasConcept C55493867 @default.
- W2087257572 hasConcept C58141971 @default.
- W2087257572 hasConcept C62826618 @default.
- W2087257572 hasConcept C71924100 @default.
- W2087257572 hasConcept C98274493 @default.
- W2087257572 hasConceptScore W2087257572C126322002 @default.
- W2087257572 hasConceptScore W2087257572C181199279 @default.
- W2087257572 hasConceptScore W2087257572C185592680 @default.
- W2087257572 hasConceptScore W2087257572C203014093 @default.
- W2087257572 hasConceptScore W2087257572C2776846068 @default.
- W2087257572 hasConceptScore W2087257572C2776958096 @default.
- W2087257572 hasConceptScore W2087257572C55493867 @default.
- W2087257572 hasConceptScore W2087257572C58141971 @default.
- W2087257572 hasConceptScore W2087257572C62826618 @default.
- W2087257572 hasConceptScore W2087257572C71924100 @default.
- W2087257572 hasConceptScore W2087257572C98274493 @default.
- W2087257572 hasIssue "3" @default.
- W2087257572 hasLocation W20872575721 @default.
- W2087257572 hasLocation W20872575722 @default.
- W2087257572 hasOpenAccess W2087257572 @default.
- W2087257572 hasPrimaryLocation W20872575721 @default.
- W2087257572 hasRelatedWork W1583794602 @default.
- W2087257572 hasRelatedWork W1959582949 @default.
- W2087257572 hasRelatedWork W1971125637 @default.
- W2087257572 hasRelatedWork W1988408001 @default.
- W2087257572 hasRelatedWork W2020117331 @default.
- W2087257572 hasRelatedWork W2034179761 @default.
- W2087257572 hasRelatedWork W2052937686 @default.
- W2087257572 hasRelatedWork W2060295670 @default.
- W2087257572 hasRelatedWork W2147743799 @default.
- W2087257572 hasRelatedWork W3148870866 @default.
- W2087257572 hasVolume "17" @default.
- W2087257572 isParatext "false" @default.
- W2087257572 isRetracted "false" @default.
- W2087257572 magId "2087257572" @default.
- W2087257572 workType "article" @default.