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• W2087270832 startingPage "2689" @default.
• W2087270832 abstract "Y294002 (LY) is a potent inhibitor of phosphatidylinositol 3-kinases (PI3Ks); however, biological applications of LY are limited by its poor solubility and pharmacokinetic profile. This study aimed at developing LY-loaded surfactant-free poly(lactic-co-glycolic acid) (PLGA) nanoparticles (SF-LY NPs) to improve the therapeutic efficacy of LY.Cellular viability was measured by MTT assay. The subcellular distribution of NPs was studied using an ultraviolet-visible spectrophotometer and confocal microscope. The expression of cell-death-associated proteins was determined using Western blotting and the in vivo activity of SF-LY NPs was tested in a xenograft animal model.SF-LY NPs enhanced the intracellular level of LY, induced sustained suppression of AKT, and induced marked cancer cell death. In addition, SF-LY NPs tended to accumulate in the endoplasmic reticulum (ER) and induce pronounced ER stress. Finally, SF-LY NPs exhibited a prominent antitumor effect in vivo.The surfactant-free formulation of PLGA is critical to the promising anticancer activity of SF-LY NPs." @default.
• W2087270832 created "2016-06-24" @default.
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• W2087270832 date "2013-07-01" @default.
• W2087270832 modified "2023-09-27" @default.
• W2087270832 title "Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly (lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway" @default.
• W2087270832 doi "https://doi.org/10.2147/ijn.s47208" @default.
• W2087270832 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3731111" @default.
• W2087270832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23940416" @default.
• W2087270832 hasPublicationYear "2013" @default.
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