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• W2087276027 startingPage "70" @default.
• W2087276027 abstract "The increasing prevalence of multi-drug resistant bacteria is driving efforts in the development of new antibacterial agents. This includes a resurgence of interest in the Gram-negative bacteria lipopolysaccharide (LPS) biosynthesis enzymes as drug targets. The six carbon acidic sugar 2-keto-3-deoxymanno-octulosonic acid (Kdo) is a component of the lipid A moiety of the LPS in Gram-negative bacteria. In most cases the lipid A substituted by Kdo is the minimum requirement for cell growth, thus presenting the possibility of targeting either the synthesis or incorporation of Kdo for the development of antibacterial agents. Indeed, potent in vitro inhibitors of Kdo biosynthesis enzymes have been reported but have so far failed to show sufficient in vivo action against Gram-negative bacteria. As part of an effort to design more potent antibacterial agents targeting Kdo biosynthesis, the crystal structures of the key Kdo biosynthesis enzymes from Escherichia coli have been solved and their structure based mechanisms characterized. In eukaryotes, Kdo is found as a component of the pectic polysaccharide rhamnogalacturonan II in the plant primary cell wall. Interestingly, despite incorporating Kdo into very different macromolecules the Kdo biosynthesis and activation pathway is almost completely conserved between plants and bacteria. This raises the possibility for plant research to exploit the increasingly detailed knowledge and resources being generated by the microbiology community. Likewise, insights into Kdo biosynthesis in plants will be potentially useful in efforts to produce new antimicrobial compounds." @default.
• W2087276027 created "2016-06-24" @default.
• W2087276027 creator A5012209799 @default.
• W2087276027 creator A5029914414 @default.
• W2087276027 date "2013-10-01" @default.
• W2087276027 modified "2023-09-23" @default.
• W2087276027 title "Conservation of the 2-keto-3-deoxymanno-octulosonic acid (Kdo) biosynthesis pathway between plants and bacteria" @default.
• W2087276027 cites W1499693169 @default.
• W2087276027 cites W1530672812 @default.
• W2087276027 cites W1636039759 @default.
• W2087276027 cites W183722190 @default.
• W2087276027 cites W1964863655 @default.
• W2087276027 cites W1965770200 @default.
• W2087276027 cites W1966277593 @default.
• W2087276027 cites W1966305447 @default.
• W2087276027 cites W1967946076 @default.
• W2087276027 cites W1971337746 @default.
• W2087276027 cites W1973673428 @default.
• W2087276027 cites W1973770464 @default.
• W2087276027 cites W1976245325 @default.
• W2087276027 cites W1978374317 @default.
• W2087276027 cites W1980208904 @default.
• W2087276027 cites W1980368941 @default.
• W2087276027 cites W1981335560 @default.
• W2087276027 cites W1983338961 @default.
• W2087276027 cites W1983416093 @default.
• W2087276027 cites W1989050750 @default.
• W2087276027 cites W1990425530 @default.
• W2087276027 cites W1991870706 @default.
• W2087276027 cites W1992611604 @default.
• W2087276027 cites W1995107325 @default.
• W2087276027 cites W1997908138 @default.
• W2087276027 cites W2009256513 @default.
• W2087276027 cites W2010272783 @default.
• W2087276027 cites W2013371029 @default.
• W2087276027 cites W2022266428 @default.
• W2087276027 cites W2023827710 @default.
• W2087276027 cites W2024117285 @default.
• W2087276027 cites W2025039617 @default.
• W2087276027 cites W2031275908 @default.
• W2087276027 cites W2036874744 @default.
• W2087276027 cites W2039048991 @default.
• W2087276027 cites W2041886444 @default.
• W2087276027 cites W2051169073 @default.
• W2087276027 cites W2054120159 @default.
• W2087276027 cites W2054724774 @default.
• W2087276027 cites W2055665403 @default.
• W2087276027 cites W2057914661 @default.
• W2087276027 cites W2059817717 @default.
• W2087276027 cites W2062058981 @default.
• W2087276027 cites W2062666691 @default.
• W2087276027 cites W2062811328 @default.
• W2087276027 cites W2064427399 @default.
• W2087276027 cites W2070260023 @default.
• W2087276027 cites W2071337049 @default.
• W2087276027 cites W2078510657 @default.
• W2087276027 cites W2079789016 @default.
• W2087276027 cites W2083107730 @default.
• W2087276027 cites W2093139681 @default.
• W2087276027 cites W2095115137 @default.
• W2087276027 cites W2096753688 @default.
• W2087276027 cites W2097928217 @default.
• W2087276027 cites W2101116153 @default.
• W2087276027 cites W2102458020 @default.
• W2087276027 cites W2106728647 @default.
• W2087276027 cites W2111182647 @default.
• W2087276027 cites W2111333015 @default.
• W2087276027 cites W2112921913 @default.
• W2087276027 cites W2113505913 @default.
• W2087276027 cites W2116774744 @default.
• W2087276027 cites W2116828898 @default.
• W2087276027 cites W2120061656 @default.
• W2087276027 cites W2121368083 @default.
• W2087276027 cites W2127720625 @default.
• W2087276027 cites W2129029669 @default.
• W2087276027 cites W2129367752 @default.
• W2087276027 cites W2137506413 @default.
• W2087276027 cites W2141251909 @default.
• W2087276027 cites W2142484332 @default.
• W2087276027 cites W2152003598 @default.
• W2087276027 cites W2154488281 @default.
• W2087276027 cites W2158163147 @default.
• W2087276027 cites W2159837327 @default.
• W2087276027 cites W2161582679 @default.
• W2087276027 cites W2161781756 @default.
• W2087276027 cites W2162647129 @default.
• W2087276027 cites W2169172728 @default.
• W2087276027 cites W2170350385 @default.
• W2087276027 cites W2171189187 @default.
• W2087276027 cites W2173272774 @default.
• W2087276027 cites W2326595712 @default.
• W2087276027 cites W2949524445 @default.
• W2087276027 cites W4234317413 @default.
• W2087276027 cites W2066335437 @default.
• W2087276027 doi "https://doi.org/10.1016/j.carres.2013.07.006" @default.
• W2087276027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23974348" @default.
• W2087276027 hasPublicationYear "2013" @default.
• W2087276027 type Work @default.

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