FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087277545> ?p ?o ?g. }

• W2087277545 endingPage "36" @default.
• W2087277545 startingPage "28" @default.
• W2087277545 abstract "Although the severity of inducible ischemia provides incremental prognostic information in persons with known or suspected coronary artery disease (CAD), its significance for predicting long-term CAD outcomes in apparently healthy populations is unknown. This study was designed to evaluate the presence and degree of myocardial ischemia in asymptomatic siblings of persons with premature CAD <60 years of age and to determine its significance for predicting incident acute coronary syndromes (ACS) during follow-up of 5 to 25 years.Siblings (n = 1,287, age 30-59 years, 55% female) were screened for traditional risk factors, underwent exercise treadmill testing with nuclear perfusion imaging, and were followed for the development of ACS (mean follow-up 11.6 ± 5.1 years). The severity of ischemia was assessed by semiquantitative methods using the standard 17-segment model and then categorized by the percent maximal summed stress score as none (0%), minimal (1% to <5%), mild (5% to 10%), moderate (10% to 15%), or severe (≥15%).ACS occurred in 132 subjects (10.3%) and included sudden cardiac death (n = 13), acute MI (n = 62), and unstable angina with revascularization (n = 57). The presence of no (88%), minimal (6%), mild (5%), and moderate/severe (1%) ischemia was associated with an ACS incidence of 8.3%, 19.7%, 25.0%, and 38.9%, respectively (P < .0001 for trend). Kaplan-Meier event-free survival analyses by myocardial ischemia severity categories showed that even minimal and mild myocardial ischemia were associated with greater ACS incidence detectable as early as 2 years after baseline. A Cox proportional hazard model, adjusted for risk factors and follow-up time, showed that each 5% increment in the severity of ischemia resulted in a 77% increase in the hazard of incident ACS (P < .001).Inducible myocardial ischemia is prevalent in asymptomatic siblings of persons with early onset CAD. Most ischemia is minimal or mild in severity, and although the severity of ischemia is associated with the risk of ACS in a graded fashion, the presence of even minimal and mild perfusion defects predicts worse CAD outcomes in this population." @default.
• W2087277545 created "2016-06-24" @default.
• W2087277545 creator A5017395254 @default.
• W2087277545 creator A5054563950 @default.
• W2087277545 creator A5066207858 @default.
• W2087277545 creator A5075754710 @default.
• W2087277545 creator A5091263959 @default.
• W2087277545 date "2011-11-12" @default.
• W2087277545 modified "2023-10-18" @default.
• W2087277545 title "Severity of inducible myocardial ischemia predicts incident acute coronary syndromes in asymptomatic individuals with a family history of premature coronary artery disease" @default.
• W2087277545 cites W1974605737 @default.
• W2087277545 cites W1983362724 @default.
• W2087277545 cites W1988212723 @default.
• W2087277545 cites W1992954786 @default.
• W2087277545 cites W2002408306 @default.
• W2087277545 cites W2023486228 @default.
• W2087277545 cites W2024951927 @default.
• W2087277545 cites W2026766157 @default.
• W2087277545 cites W2028402470 @default.
• W2087277545 cites W2036442606 @default.
• W2087277545 cites W2039421413 @default.
• W2087277545 cites W2039749223 @default.
• W2087277545 cites W2041920009 @default.
• W2087277545 cites W2051812749 @default.
• W2087277545 cites W2052098210 @default.
• W2087277545 cites W2054979122 @default.
• W2087277545 cites W2084415425 @default.
• W2087277545 cites W2102697853 @default.
• W2087277545 cites W2105766576 @default.
• W2087277545 cites W2106755781 @default.
• W2087277545 cites W2116404316 @default.
• W2087277545 cites W2123897630 @default.
• W2087277545 cites W2126509493 @default.
• W2087277545 cites W2132401137 @default.
• W2087277545 cites W2137570167 @default.
• W2087277545 cites W2154746519 @default.
• W2087277545 cites W2161018651 @default.
• W2087277545 cites W2162469891 @default.
• W2087277545 cites W2165884492 @default.
• W2087277545 cites W2254350144 @default.
• W2087277545 cites W2498108824 @default.
• W2087277545 cites W308770866 @default.
• W2087277545 cites W4317522786 @default.
• W2087277545 doi "https://doi.org/10.1007/s12350-011-9475-8" @default.
• W2087277545 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3266988" @default.
• W2087277545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22081304" @default.
• W2087277545 hasPublicationYear "2011" @default.
• W2087277545 type Work @default.
• W2087277545 sameAs 2087277545 @default.
• W2087277545 citedByCount "12" @default.
• W2087277545 countsByYear W20872775452013 @default.
• W2087277545 countsByYear W20872775452014 @default.
• W2087277545 countsByYear W20872775452016 @default.
• W2087277545 countsByYear W20872775452018 @default.
• W2087277545 countsByYear W20872775452019 @default.
• W2087277545 countsByYear W20872775452020 @default.
• W2087277545 countsByYear W20872775452021 @default.
• W2087277545 crossrefType "journal-article" @default.
• W2087277545 hasAuthorship W2087277545A5017395254 @default.
• W2087277545 hasAuthorship W2087277545A5054563950 @default.
• W2087277545 hasAuthorship W2087277545A5066207858 @default.
• W2087277545 hasAuthorship W2087277545A5075754710 @default.
• W2087277545 hasAuthorship W2087277545A5091263959 @default.
• W2087277545 hasBestOaLocation W20872775452 @default.
• W2087277545 hasConcept C120665830 @default.
• W2087277545 hasConcept C121332964 @default.
• W2087277545 hasConcept C126322002 @default.
• W2087277545 hasConcept C164705383 @default.
• W2087277545 hasConcept C2777698277 @default.
• W2087277545 hasConcept C2777785093 @default.
• W2087277545 hasConcept C2777910003 @default.
• W2087277545 hasConcept C2778213512 @default.
• W2087277545 hasConcept C2778405248 @default.
• W2087277545 hasConcept C2778425758 @default.
• W2087277545 hasConcept C2779464278 @default.
• W2087277545 hasConcept C500558357 @default.
• W2087277545 hasConcept C541997718 @default.
• W2087277545 hasConcept C61511704 @default.
• W2087277545 hasConcept C71924100 @default.
• W2087277545 hasConceptScore W2087277545C120665830 @default.
• W2087277545 hasConceptScore W2087277545C121332964 @default.
• W2087277545 hasConceptScore W2087277545C126322002 @default.
• W2087277545 hasConceptScore W2087277545C164705383 @default.
• W2087277545 hasConceptScore W2087277545C2777698277 @default.
• W2087277545 hasConceptScore W2087277545C2777785093 @default.
• W2087277545 hasConceptScore W2087277545C2777910003 @default.
• W2087277545 hasConceptScore W2087277545C2778213512 @default.
• W2087277545 hasConceptScore W2087277545C2778405248 @default.
• W2087277545 hasConceptScore W2087277545C2778425758 @default.
• W2087277545 hasConceptScore W2087277545C2779464278 @default.
• W2087277545 hasConceptScore W2087277545C500558357 @default.
• W2087277545 hasConceptScore W2087277545C541997718 @default.
• W2087277545 hasConceptScore W2087277545C61511704 @default.
• W2087277545 hasConceptScore W2087277545C71924100 @default.
• W2087277545 hasIssue "1" @default.
• W2087277545 hasLocation W20872775451 @default.
• W2087277545 hasLocation W20872775452 @default.
• W2087277545 hasLocation W20872775453 @default.

• next