FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087278907> ?p ?o ?g. }

• W2087278907 endingPage "228" @default.
• W2087278907 startingPage "223" @default.
• W2087278907 abstract "Purpose:To investigate the distribution of statin therapy correlated gene polymorphism allele CYP2D6*10 (C188T) in Ningxia Hui nationality and to discuss the relationship between the gene polymorphism allele CYP2D6*10 (C188T) and the lipid-lowering efficacy of simvastatin and hyperlipidemia.Materials and methods:One hundred and fifty healthy people (80 males and 70 females) and 200 hyperlipidemia patients (105 males and 95 females) were recruited at Ningxia People’s Hospital. Genotypes were determined by using allele-specific amplification (ASA-PCR) in 150 healthy controls and 200 patients with hyperlipidemia. Relationships between genotypes and lipid levels and the lipid-lowering efficacy of simvastatin were analyzed.Results:The distribution frequency of the CYP2D6*10 allele was 47.6% in the Ningxia Hui nationality. There was no significant correlation between the CYP2D6*10 allele and hyperlipidemia. At 8 weeks after treatment with simvastatin, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were more obviously decreased with the CC genotype than the CT and TT genotypes, with significant differences.Conclusion:Distribution of the gene polymorphism of CYP2D6*10 is ethnically and geographical different. The allele T of CYP2D6*10 is not related to hyperlipidemia. CC expression seemed to increase the lipid-lowering effects of simvastatin. The hyperlipidemia patients with CC genotype should take lower doses of simvastatin than those with CT/TT genotype in the Ningxia Hui population." @default.
• W2087278907 created "2016-06-24" @default.
• W2087278907 creator A5020555526 @default.
• W2087278907 creator A5026091430 @default.
• W2087278907 creator A5029884312 @default.
• W2087278907 creator A5037334228 @default.
• W2087278907 creator A5042565448 @default.
• W2087278907 creator A5051008763 @default.
• W2087278907 creator A5054077149 @default.
• W2087278907 date "2013-11-06" @default.
• W2087278907 modified "2023-10-11" @default.
• W2087278907 title "Statin therapy correlated CYP2D6 gene polymorphism and hyperlipidemia" @default.
• W2087278907 cites W1548555206 @default.
• W2087278907 cites W1972329707 @default.
• W2087278907 cites W1986761759 @default.
• W2087278907 cites W2008825099 @default.
• W2087278907 cites W2011527537 @default.
• W2087278907 cites W2016110627 @default.
• W2087278907 cites W2027165739 @default.
• W2087278907 cites W2030995672 @default.
• W2087278907 cites W2072288084 @default.
• W2087278907 cites W2074022399 @default.
• W2087278907 cites W2085815634 @default.
• W2087278907 cites W2087813680 @default.
• W2087278907 cites W2095575057 @default.
• W2087278907 cites W2106730641 @default.
• W2087278907 cites W2108799014 @default.
• W2087278907 cites W2121074897 @default.
• W2087278907 cites W2128384465 @default.
• W2087278907 cites W2137587714 @default.
• W2087278907 cites W2138332753 @default.
• W2087278907 cites W2158635723 @default.
• W2087278907 cites W4241199384 @default.
• W2087278907 doi "https://doi.org/10.1185/03007995.2013.858619" @default.
• W2087278907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24156754" @default.
• W2087278907 hasPublicationYear "2013" @default.
• W2087278907 type Work @default.
• W2087278907 sameAs 2087278907 @default.
• W2087278907 citedByCount "9" @default.
• W2087278907 countsByYear W20872789072014 @default.
• W2087278907 countsByYear W20872789072015 @default.
• W2087278907 countsByYear W20872789072016 @default.
• W2087278907 countsByYear W20872789072017 @default.
• W2087278907 countsByYear W20872789072018 @default.
• W2087278907 countsByYear W20872789072019 @default.
• W2087278907 countsByYear W20872789072023 @default.
• W2087278907 crossrefType "journal-article" @default.
• W2087278907 hasAuthorship W2087278907A5020555526 @default.
• W2087278907 hasAuthorship W2087278907A5026091430 @default.
• W2087278907 hasAuthorship W2087278907A5029884312 @default.
• W2087278907 hasAuthorship W2087278907A5037334228 @default.
• W2087278907 hasAuthorship W2087278907A5042565448 @default.
• W2087278907 hasAuthorship W2087278907A5051008763 @default.
• W2087278907 hasAuthorship W2087278907A5054077149 @default.
• W2087278907 hasConcept C104317684 @default.
• W2087278907 hasConcept C126322002 @default.
• W2087278907 hasConcept C134018914 @default.
• W2087278907 hasConcept C135763542 @default.
• W2087278907 hasConcept C149737253 @default.
• W2087278907 hasConcept C180754005 @default.
• W2087278907 hasConcept C2776329913 @default.
• W2087278907 hasConcept C2776839432 @default.
• W2087278907 hasConcept C2778163477 @default.
• W2087278907 hasConcept C2778270857 @default.
• W2087278907 hasConcept C2779091943 @default.
• W2087278907 hasConcept C2908647359 @default.
• W2087278907 hasConcept C37463918 @default.
• W2087278907 hasConcept C54355233 @default.
• W2087278907 hasConcept C555293320 @default.
• W2087278907 hasConcept C71924100 @default.
• W2087278907 hasConcept C76252995 @default.
• W2087278907 hasConcept C86803240 @default.
• W2087278907 hasConcept C90924648 @default.
• W2087278907 hasConcept C99454951 @default.
• W2087278907 hasConceptScore W2087278907C104317684 @default.
• W2087278907 hasConceptScore W2087278907C126322002 @default.
• W2087278907 hasConceptScore W2087278907C134018914 @default.
• W2087278907 hasConceptScore W2087278907C135763542 @default.
• W2087278907 hasConceptScore W2087278907C149737253 @default.
• W2087278907 hasConceptScore W2087278907C180754005 @default.
• W2087278907 hasConceptScore W2087278907C2776329913 @default.
• W2087278907 hasConceptScore W2087278907C2776839432 @default.
• W2087278907 hasConceptScore W2087278907C2778163477 @default.
• W2087278907 hasConceptScore W2087278907C2778270857 @default.
• W2087278907 hasConceptScore W2087278907C2779091943 @default.
• W2087278907 hasConceptScore W2087278907C2908647359 @default.
• W2087278907 hasConceptScore W2087278907C37463918 @default.
• W2087278907 hasConceptScore W2087278907C54355233 @default.
• W2087278907 hasConceptScore W2087278907C555293320 @default.
• W2087278907 hasConceptScore W2087278907C71924100 @default.
• W2087278907 hasConceptScore W2087278907C76252995 @default.
• W2087278907 hasConceptScore W2087278907C86803240 @default.
• W2087278907 hasConceptScore W2087278907C90924648 @default.
• W2087278907 hasConceptScore W2087278907C99454951 @default.
• W2087278907 hasIssue "2" @default.
• W2087278907 hasLocation W20872789071 @default.
• W2087278907 hasLocation W20872789072 @default.
• W2087278907 hasOpenAccess W2087278907 @default.

• next