Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087287002> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2087287002 endingPage "207" @default.
- W2087287002 startingPage "204" @default.
- W2087287002 abstract "Photodynamic therapy (PDT) has been described in terms of cellular and vascular effects. The precise mechanisms of cellular and vascular damage are still unknown. In this study, the photodynamic inactivation of endothelial cells in vitro and damage to the microvasculature in vivo by naturally occurring porphyrins (uroporphyrin III (UP), coproporphyrin III (CP) and protoporphyrin IX (PP)) were investigated. The chick chorioallantoic membrane model (CAM model) was used, which is convenient for the study of damage to the microcirculation induced by PDT. The hydrophilic porphyrins UP and CP exhibited low cytotoxicity towards endothelial cells. Only small amounts of UP and CP were taken up, resulting in weak inactivation after irradiation. In contrast, the more lipophilic PP showed a marked cytotoxicity. Considerable amounts of PP were accumulated in the cells, leading to pronounced inactivation after light exposure. For the three porphyrins, damage to the microvasculature was observed. The damage caused by the hydrophilic porphyrins UP and CP was strongly dependent on the drug and light dose. For vascular injury, the efficacy was graded as UP < CP < PP." @default.
- W2087287002 created "2016-06-24" @default.
- W2087287002 creator A5022930343 @default.
- W2087287002 creator A5046114692 @default.
- W2087287002 creator A5046229052 @default.
- W2087287002 date "1992-01-01" @default.
- W2087287002 modified "2023-09-26" @default.
- W2087287002 title "The chick chorioallantoic membrane (CAM) as an in vivo model for photodynamic therapy" @default.
- W2087287002 cites W1990534487 @default.
- W2087287002 cites W2011005076 @default.
- W2087287002 cites W2071389244 @default.
- W2087287002 cites W2318852716 @default.
- W2087287002 cites W2396847665 @default.
- W2087287002 cites W4211002736 @default.
- W2087287002 doi "https://doi.org/10.1016/1011-1344(92)85010-r" @default.
- W2087287002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1619519" @default.
- W2087287002 hasPublicationYear "1992" @default.
- W2087287002 type Work @default.
- W2087287002 sameAs 2087287002 @default.
- W2087287002 citedByCount "11" @default.
- W2087287002 countsByYear W20872870022012 @default.
- W2087287002 countsByYear W20872870022019 @default.
- W2087287002 crossrefType "journal-article" @default.
- W2087287002 hasAuthorship W2087287002A5022930343 @default.
- W2087287002 hasAuthorship W2087287002A5046114692 @default.
- W2087287002 hasAuthorship W2087287002A5046229052 @default.
- W2087287002 hasConcept C109316439 @default.
- W2087287002 hasConcept C123012128 @default.
- W2087287002 hasConcept C12554922 @default.
- W2087287002 hasConcept C126322002 @default.
- W2087287002 hasConcept C12722491 @default.
- W2087287002 hasConcept C150903083 @default.
- W2087287002 hasConcept C178790620 @default.
- W2087287002 hasConcept C185592680 @default.
- W2087287002 hasConcept C202751555 @default.
- W2087287002 hasConcept C207001950 @default.
- W2087287002 hasConcept C2778417259 @default.
- W2087287002 hasConcept C2779480358 @default.
- W2087287002 hasConcept C2779671804 @default.
- W2087287002 hasConcept C2781323092 @default.
- W2087287002 hasConcept C2781469039 @default.
- W2087287002 hasConcept C55493867 @default.
- W2087287002 hasConcept C71924100 @default.
- W2087287002 hasConcept C75473681 @default.
- W2087287002 hasConcept C86803240 @default.
- W2087287002 hasConcept C95444343 @default.
- W2087287002 hasConcept C97230052 @default.
- W2087287002 hasConceptScore W2087287002C109316439 @default.
- W2087287002 hasConceptScore W2087287002C123012128 @default.
- W2087287002 hasConceptScore W2087287002C12554922 @default.
- W2087287002 hasConceptScore W2087287002C126322002 @default.
- W2087287002 hasConceptScore W2087287002C12722491 @default.
- W2087287002 hasConceptScore W2087287002C150903083 @default.
- W2087287002 hasConceptScore W2087287002C178790620 @default.
- W2087287002 hasConceptScore W2087287002C185592680 @default.
- W2087287002 hasConceptScore W2087287002C202751555 @default.
- W2087287002 hasConceptScore W2087287002C207001950 @default.
- W2087287002 hasConceptScore W2087287002C2778417259 @default.
- W2087287002 hasConceptScore W2087287002C2779480358 @default.
- W2087287002 hasConceptScore W2087287002C2779671804 @default.
- W2087287002 hasConceptScore W2087287002C2781323092 @default.
- W2087287002 hasConceptScore W2087287002C2781469039 @default.
- W2087287002 hasConceptScore W2087287002C55493867 @default.
- W2087287002 hasConceptScore W2087287002C71924100 @default.
- W2087287002 hasConceptScore W2087287002C75473681 @default.
- W2087287002 hasConceptScore W2087287002C86803240 @default.
- W2087287002 hasConceptScore W2087287002C95444343 @default.
- W2087287002 hasConceptScore W2087287002C97230052 @default.
- W2087287002 hasIssue "2" @default.
- W2087287002 hasLocation W20872870021 @default.
- W2087287002 hasLocation W20872870022 @default.
- W2087287002 hasOpenAccess W2087287002 @default.
- W2087287002 hasPrimaryLocation W20872870021 @default.
- W2087287002 hasRelatedWork W1964890231 @default.
- W2087287002 hasRelatedWork W1988584356 @default.
- W2087287002 hasRelatedWork W1999394278 @default.
- W2087287002 hasRelatedWork W2046499755 @default.
- W2087287002 hasRelatedWork W2051085229 @default.
- W2087287002 hasRelatedWork W2056839504 @default.
- W2087287002 hasRelatedWork W2609389851 @default.
- W2087287002 hasRelatedWork W2793051123 @default.
- W2087287002 hasRelatedWork W2901643274 @default.
- W2087287002 hasRelatedWork W1645908513 @default.
- W2087287002 hasVolume "12" @default.
- W2087287002 isParatext "false" @default.
- W2087287002 isRetracted "false" @default.
- W2087287002 magId "2087287002" @default.
- W2087287002 workType "article" @default.