FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087287360> ?p ?o ?g. }

• W2087287360 endingPage "9832" @default.
• W2087287360 startingPage "9827" @default.
• W2087287360 abstract "Activator protein-1 (AP-1) is a transcription factor that consists of either a Jun-Jun homodimer or a Jun-Fos heterodimer. Transactivation of AP-1 is required for tumor promoter-induced transformation in mouse epidermal JB6 cells and for progression in mouse and human keratinocytes. Until now, the question of whether AP-1 transactivation is required for carcinogenesis in vivo has remained unanswered, as has the issue of functionally significant target genes. To address these issues we have generated a transgenic mouse in which transactivation mutant c-jun (TAM67), under the control of the human keratin-14 promoter, is expressed specifically in the basal cells of the epidermis where tumor induction is initiated. The keratin-14-TAM67 transgene was expressed in the epidermis, tongue, and cervix, with no apparent abnormalities in any tissue or organ. TAM67 expression blocked 12-O-tetradecanoylphorbol 13-acetate (TPA, phorbol 12-tetradecanoate 13-acetate) induction of the AP-1-regulated luciferase in AP-1 luciferase/TAM67 mice, but did not inhibit induction of candidate AP-1 target genes, collagenase-1 or stromelysin-3. More interestingly, TAM67 expression did not inhibit TPA-induced hyperproliferation. In two-stage skin carcinogenesis experiments, the transgenic animals showed a dramatic inhibition of papilloma induction. We conclude that transactivation of a subset of AP-1-dependent genes is required for tumor promotion and may be targeted for cancer prevention." @default.
• W2087287360 created "2016-06-24" @default.
• W2087287360 creator A5000681392 @default.
• W2087287360 creator A5023118874 @default.
• W2087287360 creator A5048962207 @default.
• W2087287360 creator A5051208328 @default.
• W2087287360 creator A5064443404 @default.
• W2087287360 creator A5076606686 @default.
• W2087287360 creator A5088883233 @default.
• W2087287360 date "1999-08-17" @default.
• W2087287360 modified "2023-10-02" @default.
• W2087287360 title "Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion" @default.
• W2087287360 cites W1512065983 @default.
• W2087287360 cites W1529419844 @default.
• W2087287360 cites W1533943681 @default.
• W2087287360 cites W1617897652 @default.
• W2087287360 cites W1955283045 @default.
• W2087287360 cites W1963529390 @default.
• W2087287360 cites W1963842999 @default.
• W2087287360 cites W1964303657 @default.
• W2087287360 cites W1965198668 @default.
• W2087287360 cites W1967004332 @default.
• W2087287360 cites W1972952746 @default.
• W2087287360 cites W1978908854 @default.
• W2087287360 cites W1987134853 @default.
• W2087287360 cites W1987453246 @default.
• W2087287360 cites W1993785975 @default.
• W2087287360 cites W1995723368 @default.
• W2087287360 cites W2008761160 @default.
• W2087287360 cites W2009379675 @default.
• W2087287360 cites W2011047085 @default.
• W2087287360 cites W2017030322 @default.
• W2087287360 cites W2022030450 @default.
• W2087287360 cites W2024575518 @default.
• W2087287360 cites W2026181894 @default.
• W2087287360 cites W2029144008 @default.
• W2087287360 cites W2031605972 @default.
• W2087287360 cites W2039323907 @default.
• W2087287360 cites W2044375623 @default.
• W2087287360 cites W2046983903 @default.
• W2087287360 cites W2051561977 @default.
• W2087287360 cites W2053380164 @default.
• W2087287360 cites W2075238780 @default.
• W2087287360 cites W2078517996 @default.
• W2087287360 cites W2079988105 @default.
• W2087287360 cites W2083517465 @default.
• W2087287360 cites W2086880360 @default.
• W2087287360 cites W2090429649 @default.
• W2087287360 cites W2120818551 @default.
• W2087287360 cites W2122172764 @default.
• W2087287360 cites W2126779118 @default.
• W2087287360 cites W2130757381 @default.
• W2087287360 cites W2140582490 @default.
• W2087287360 cites W2162609478 @default.
• W2087287360 cites W2301725678 @default.
• W2087287360 cites W2406069463 @default.
• W2087287360 cites W2413797298 @default.
• W2087287360 cites W2414173708 @default.
• W2087287360 cites W2416585022 @default.
• W2087287360 cites W2417534639 @default.
• W2087287360 cites W2417887498 @default.
• W2087287360 cites W2444166999 @default.
• W2087287360 cites W4237319010 @default.
• W2087287360 cites W43634832 @default.
• W2087287360 doi "https://doi.org/10.1073/pnas.96.17.9827" @default.
• W2087287360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/22295" @default.
• W2087287360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10449779" @default.
• W2087287360 hasPublicationYear "1999" @default.
• W2087287360 type Work @default.
• W2087287360 sameAs 2087287360 @default.
• W2087287360 citedByCount "369" @default.
• W2087287360 countsByYear W20872873602012 @default.
• W2087287360 countsByYear W20872873602013 @default.
• W2087287360 countsByYear W20872873602014 @default.
• W2087287360 countsByYear W20872873602015 @default.
• W2087287360 countsByYear W20872873602016 @default.
• W2087287360 countsByYear W20872873602017 @default.
• W2087287360 countsByYear W20872873602018 @default.
• W2087287360 countsByYear W20872873602019 @default.
• W2087287360 countsByYear W20872873602020 @default.
• W2087287360 countsByYear W20872873602021 @default.
• W2087287360 countsByYear W20872873602022 @default.
• W2087287360 countsByYear W20872873602023 @default.
• W2087287360 crossrefType "journal-article" @default.
• W2087287360 hasAuthorship W2087287360A5000681392 @default.
• W2087287360 hasAuthorship W2087287360A5023118874 @default.
• W2087287360 hasAuthorship W2087287360A5048962207 @default.
• W2087287360 hasAuthorship W2087287360A5051208328 @default.
• W2087287360 hasAuthorship W2087287360A5064443404 @default.
• W2087287360 hasAuthorship W2087287360A5076606686 @default.
• W2087287360 hasAuthorship W2087287360A5088883233 @default.
• W2087287360 hasBestOaLocation W20872873602 @default.
• W2087287360 hasConcept C102230213 @default.
• W2087287360 hasConcept C104317684 @default.
• W2087287360 hasConcept C1292079 @default.
• W2087287360 hasConcept C153911025 @default.
• W2087287360 hasConcept C2780122803 @default.
• W2087287360 hasConcept C502942594 @default.

• next