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• W2087287514 endingPage "5720" @default.
• W2087287514 startingPage "5710" @default.
• W2087287514 abstract "The synthesis and binding study of new 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide 3-ester compounds are reported. A pharmacological evaluation of the high-affinity ligands 1−4 belonging to the 3-heteroarylester series is made. The 3-(2-thienylmethoxycarbonyl) derivative 4 stands out from the other heteroarylesters and is found, using nine different behavioral methods, to be a functionally selective ligand in vivo: it shows anxiolytic-like activity in the conflict models (light-dark box and plus maze test) similarly to diazepam, without any sedative and amnesic properties or interference from alcohol." @default.
• W2087287514 created "2016-06-24" @default.
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• W2087287514 date "2002-11-21" @default.
• W2087287514 modified "2023-09-24" @default.
• W2087287514 title "Benzodiazepine Receptor Ligands. 7. Synthesis and Pharmacological Evaluation of New 3-Esters of the 8-Chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) Derivative: An Anxioselective Agent in Rodents" @default.
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• W2087287514 doi "https://doi.org/10.1021/jm020944u" @default.
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