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- W2087291244 abstract "Single ion channel currents can only provide indirect information on channel molecular events (except for timing). In contrast, the electric displacement currents associated with channel gating, termed gating currents, can provide direct information regarding the channel molecule's conformational changes. However, thus far gating currents have been measured only from ensembles of numerous stochastically activated channels and therefore the information they provide is limited. This work presents, for the first time, measurements of gating currents from a single channel molecule. Averaging close to 8000 pre-open currents, aligned to the single channel opening time, enabled the detection of single channel gating currents with a resolution of 2 electron charges. The measured charge displacements show: 1) a slow component, approximately 2 fA above baseline level, assumed to represent stochastic conformational changes, and 2) transients, the most significant of which occur 1.1 and 0.3 ms before channel opening. The transients most likely represent apparent deterministic stages in the gating process. The largest transient current peak was 5.1 +/- 1.6 fA and the total equivalent charge transported across the membrane was 4.7 +/- 2.5 electron charges. This data is unique also in that it presents monitoring of the behavior of a single, well-defined macromolecule." @default.
- W2087291244 created "2016-06-24" @default.
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- W2087291244 date "1994-10-01" @default.
- W2087291244 modified "2023-09-27" @default.
- W2087291244 title "Charge displacements in a single potassium ion channel macromolecule during gating" @default.
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- W2087291244 doi "https://doi.org/10.1016/s0006-3495(94)80619-8" @default.
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