FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087293350> ?p ?o ?g. }

• W2087293350 endingPage "119" @default.
• W2087293350 startingPage "109" @default.
• W2087293350 abstract "A simple, yet efficient, two-column simulated moving-bed (2CSMB) process for purifying adenovirus serotype 5 (Ad5) by size-exclusion chromatography (SEC) is presented and validated experimentally, and a general procedure for its robust design under parameter uncertainty is described. The pilot-scale run yielded a virus recovery of 86 percent and DNA and HCP clearances of 90 and 89 percent, respectively, without any fine tuning of the operating parameters. This performance compares very favorably against that of single-column batch chromatography for the same volume of size-exclusion resin. To improve the robustness of the 2CSMB-SEC process the best set of operating parameters is selected only among candidate solutions that are robust feasible, that is, remain feasible for all parameter perturbations within their uncertainty intervals. This robust approach to optimal design replaces the nominal problem by a worst case problem. Computational tractability is ensured by formulating the robust design problem with only the vertices of the uncertainty region that have the worst effect on the product purity and recovery. The robust design is exemplified on the case where the column volume and interparticle porosity are subject to uncertainty. As expected, to increase the robustness of the 2CSMB-SEC process it is necessary to reduce its productivity and increase its solvent consumption. Nevertheless, the design solution given by our robust approach is the least detrimental of all feasible operating conditions for the 2CSMB-SEC process." @default.
• W2087293350 created "2016-06-24" @default.
• W2087293350 creator A5000342045 @default.
• W2087293350 creator A5021060711 @default.
• W2087293350 creator A5038667460 @default.
• W2087293350 creator A5041231390 @default.
• W2087293350 creator A5045894470 @default.
• W2087293350 creator A5057870845 @default.
• W2087293350 date "2015-11-01" @default.
• W2087293350 modified "2023-09-23" @default.
• W2087293350 title "Robust design of adenovirus purification by two-column, simulated moving-bed, size-exclusion chromatography" @default.
• W2087293350 cites W1968567648 @default.
• W2087293350 cites W1972036299 @default.
• W2087293350 cites W1972731139 @default.
• W2087293350 cites W1975132204 @default.
• W2087293350 cites W1978568913 @default.
• W2087293350 cites W1981752210 @default.
• W2087293350 cites W1985343676 @default.
• W2087293350 cites W1994580989 @default.
• W2087293350 cites W1996059448 @default.
• W2087293350 cites W2000599654 @default.
• W2087293350 cites W2003808096 @default.
• W2087293350 cites W2006093909 @default.
• W2087293350 cites W2009912950 @default.
• W2087293350 cites W2017707954 @default.
• W2087293350 cites W2019558818 @default.
• W2087293350 cites W2023319905 @default.
• W2087293350 cites W2025818017 @default.
• W2087293350 cites W2026449883 @default.
• W2087293350 cites W2028784548 @default.
• W2087293350 cites W2039739473 @default.
• W2087293350 cites W2053632726 @default.
• W2087293350 cites W2055515273 @default.
• W2087293350 cites W2068284297 @default.
• W2087293350 cites W2073489740 @default.
• W2087293350 cites W2074619604 @default.
• W2087293350 cites W2083886150 @default.
• W2087293350 cites W2084295772 @default.
• W2087293350 cites W2084976117 @default.
• W2087293350 cites W2086154585 @default.
• W2087293350 cites W2090812230 @default.
• W2087293350 cites W2123871098 @default.
• W2087293350 cites W2136989960 @default.
• W2087293350 cites W2142397163 @default.
• W2087293350 cites W2144736256 @default.
• W2087293350 cites W2168339645 @default.
• W2087293350 cites W2168863535 @default.
• W2087293350 cites W2169402836 @default.
• W2087293350 cites W2320830845 @default.
• W2087293350 doi "https://doi.org/10.1016/j.jbiotec.2015.01.030" @default.
• W2087293350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25744665" @default.
• W2087293350 hasPublicationYear "2015" @default.
• W2087293350 type Work @default.
• W2087293350 sameAs 2087293350 @default.
• W2087293350 citedByCount "32" @default.
• W2087293350 countsByYear W20872933502015 @default.
• W2087293350 countsByYear W20872933502016 @default.
• W2087293350 countsByYear W20872933502017 @default.
• W2087293350 countsByYear W20872933502018 @default.
• W2087293350 countsByYear W20872933502019 @default.
• W2087293350 countsByYear W20872933502020 @default.
• W2087293350 countsByYear W20872933502021 @default.
• W2087293350 countsByYear W20872933502022 @default.
• W2087293350 countsByYear W20872933502023 @default.
• W2087293350 crossrefType "journal-article" @default.
• W2087293350 hasAuthorship W2087293350A5000342045 @default.
• W2087293350 hasAuthorship W2087293350A5021060711 @default.
• W2087293350 hasAuthorship W2087293350A5038667460 @default.
• W2087293350 hasAuthorship W2087293350A5041231390 @default.
• W2087293350 hasAuthorship W2087293350A5045894470 @default.
• W2087293350 hasAuthorship W2087293350A5057870845 @default.
• W2087293350 hasConcept C104317684 @default.
• W2087293350 hasConcept C126255220 @default.
• W2087293350 hasConcept C127413603 @default.
• W2087293350 hasConcept C150394285 @default.
• W2087293350 hasConcept C178790620 @default.
• W2087293350 hasConcept C181199279 @default.
• W2087293350 hasConcept C185592680 @default.
• W2087293350 hasConcept C193363816 @default.
• W2087293350 hasConcept C21880701 @default.
• W2087293350 hasConcept C2778088075 @default.
• W2087293350 hasConcept C33923547 @default.
• W2087293350 hasConcept C41008148 @default.
• W2087293350 hasConcept C43617362 @default.
• W2087293350 hasConcept C55493867 @default.
• W2087293350 hasConcept C63479239 @default.
• W2087293350 hasConceptScore W2087293350C104317684 @default.
• W2087293350 hasConceptScore W2087293350C126255220 @default.
• W2087293350 hasConceptScore W2087293350C127413603 @default.
• W2087293350 hasConceptScore W2087293350C150394285 @default.
• W2087293350 hasConceptScore W2087293350C178790620 @default.
• W2087293350 hasConceptScore W2087293350C181199279 @default.
• W2087293350 hasConceptScore W2087293350C185592680 @default.
• W2087293350 hasConceptScore W2087293350C193363816 @default.
• W2087293350 hasConceptScore W2087293350C21880701 @default.
• W2087293350 hasConceptScore W2087293350C2778088075 @default.
• W2087293350 hasConceptScore W2087293350C33923547 @default.
• W2087293350 hasConceptScore W2087293350C41008148 @default.

• next