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- W2087299325 abstract "To the Editor: Antihistamines are widely used as therapeutic agents, both as over the counter and as prescription medication. They appear in cold and cough formulations, often in combination with sympathomimetic drugs. They are also used as over the counter sleep aides and as treatment for skin itching and other symptoms resulting from allergic reactions. Because of the widespread availability and usage of antihistamines, it is not surprising that these drugs are identified during routine drug testing in many medical examiner cases. The following is a compilation of data accumulated at the Office of the Chief Medical Examiner, State of Maryland, and at the Armed Forces Institute of Pathology on postmortem antihistamine concentrations in non-intoxication cases. Specifically, blood and liver concentrations of diphenhydramine, doxylamine, and chlorpheniramine were tabulated. The purpose of this work was to establish a postmortem therapeutic range for these drugs, and to establish a data base for liver concentrations to enable interpretation of a liver antihistamine concentration in combination with or in the absence of the corresponding blood concentration. The data collected on non-intoxication cases involving chlorpheniramine, diphenhydramine, and doxylamine are provided in Table 1. Criteria for inclusion into this study were the following: (1) the antihistamine was confirmed and" @default.
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- W2087299325 date "1996-07-01" @default.
- W2087299325 modified "2023-09-28" @default.
- W2087299325 title "Antihistamine concentrations in postmortem blood and liver specimens" @default.
- W2087299325 cites W2895087986 @default.
- W2087299325 doi "https://doi.org/10.1016/0379-0738(96)01944-5" @default.
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