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- W2087303984 abstract "The multi-millicurie synthesis of the D-2 receptor ligand [18F](3-N-methyl)benperidol (NMB; 1-[3-(4′-[18F]fluorobenzoyl)propyl]-4-(2-keto-3-methyl-1-benzimidazolinyl)piperidine) is described. [18F]NMB was produced via a 3-step reaction sequence with an overall radiochemical yield of 5–10% and a specific activity > 3000 Ci/mmol within 100 min. In vitro binding assays indicated that NMB has high affinity for D-2 receptors in primate brain (Ki = 3.6 nM), with a receptor specificity exceeding that of spiperone. The technique described here permits the routine production of 10–20 mCi of this promising radiopharmaceutical for PET study of D-2 receptor binding in vivo." @default.
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- W2087303984 date "1992-07-01" @default.
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- W2087303984 title "Production of fluorine-18 labeled (3-N-methyl)benperidol for PET investigation of cerebral dopaminergic receptor binding" @default.
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- W2087303984 doi "https://doi.org/10.1016/0883-2889(92)90155-8" @default.
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