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• W2087306739 abstract "Ebselen, a new organoselenium compound with pronounced anti-inflammatory properties, selectively inhibits the formation of leukotriene B4 in human and porcine leukocytes with half-maximal inhibition at 4.0 and 2.7 μmol/l, respectively. The underlying mechanism was found to be a cis-trans-isomerisation of leukotriene B4 to the 5S,12R-6-trans-isomer. 5-Hydroxy-eicosatetraenoic acid was also isomerised to the 8-trans-isomer. At higher concentrations, ebselen induces a dose-dependent decrease in the sum of total 5-lipoxygenase products with half-maximal inhibition at 30 μmol/l. Additionally, the effects of ebselen on human platelet 12-lipoxygenase and cyclooxygenase were investigated. Human platelet 12-lipoxygenase and cyclooxygenase were inhibited in a dose dependent manner with half-maximal inhibition at 20 μmol/l and 5 μmol/l, respectively. We suggest that suppression of leukotriene B4-formation by isomerisation to a biologically inactive compound represents a promising approach to the therapy of inflammation." @default.
• W2087306739 created "2016-06-24" @default.
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• W2087306739 date "1986-06-01" @default.
• W2087306739 modified "2023-09-27" @default.
• W2087306739 title "Ebselen reduces the formation of LTB4 in human and porcine leukocytes by isomerisation to its 5S, 12R-6-trans-isomer" @default.
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• W2087306739 doi "https://doi.org/10.1016/0090-6980(86)90207-8" @default.
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