Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087307714> ?p ?o ?g. }
- W2087307714 endingPage "e29260" @default.
- W2087307714 startingPage "e29260" @default.
- W2087307714 abstract "Lysophosphatidic acid (LPA), a lipid mediator enriched in serum, stimulates cell migration, proliferation and other functions in many cell types. LPA acts on six known G protein-coupled receptors, termed LPA1–6, showing both overlapping and distinct signaling properties. Here we show that, unexpectedly, LPA and serum almost completely inhibit the transwell migration of B16 melanoma cells, with alkyl-LPA(18∶1) being 10-fold more potent than acyl-LPA(18∶1). The anti-migratory response to LPA is highly polarized and dependent on protein kinase A (PKA) but not Rho kinase activity; it is associated with a rapid increase in intracellular cAMP levels and PIP3 depletion from the plasma membrane. B16 cells express LPA2, LPA5 and LPA6 receptors. We show that LPA-induced chemorepulsion is mediated specifically by the alkyl-LPA-preferring LPA5 receptor (GPR92), which raises intracellular cAMP via a noncanonical pathway. Our results define LPA5 as an anti-migratory receptor and they implicate the cAMP-PKA pathway, along with reduced PIP3 signaling, as an effector of chemorepulsion in B16 melanoma cells." @default.
- W2087307714 created "2016-06-24" @default.
- W2087307714 creator A5005567648 @default.
- W2087307714 creator A5019907039 @default.
- W2087307714 creator A5022196859 @default.
- W2087307714 creator A5047111647 @default.
- W2087307714 creator A5061490638 @default.
- W2087307714 date "2011-12-14" @default.
- W2087307714 modified "2023-10-03" @default.
- W2087307714 title "LPA Is a Chemorepellent for B16 Melanoma Cells: Action through the cAMP-Elevating LPA5 Receptor" @default.
- W2087307714 cites W1776576701 @default.
- W2087307714 cites W1885709862 @default.
- W2087307714 cites W1966163661 @default.
- W2087307714 cites W1979793199 @default.
- W2087307714 cites W1982426576 @default.
- W2087307714 cites W1987520856 @default.
- W2087307714 cites W1995962617 @default.
- W2087307714 cites W1999599951 @default.
- W2087307714 cites W2002194264 @default.
- W2087307714 cites W2006993784 @default.
- W2087307714 cites W2009707750 @default.
- W2087307714 cites W2031992146 @default.
- W2087307714 cites W2034566357 @default.
- W2087307714 cites W2036011686 @default.
- W2087307714 cites W2037831313 @default.
- W2087307714 cites W2045140739 @default.
- W2087307714 cites W2053223380 @default.
- W2087307714 cites W2053504505 @default.
- W2087307714 cites W2064638211 @default.
- W2087307714 cites W2068879726 @default.
- W2087307714 cites W2069854015 @default.
- W2087307714 cites W2072840386 @default.
- W2087307714 cites W2081848364 @default.
- W2087307714 cites W2084676297 @default.
- W2087307714 cites W2094210837 @default.
- W2087307714 cites W2099417362 @default.
- W2087307714 cites W2105029267 @default.
- W2087307714 cites W2106551540 @default.
- W2087307714 cites W2116722103 @default.
- W2087307714 cites W2120084535 @default.
- W2087307714 cites W2120639213 @default.
- W2087307714 cites W2124900560 @default.
- W2087307714 cites W2126704964 @default.
- W2087307714 cites W2130057582 @default.
- W2087307714 cites W2139655221 @default.
- W2087307714 cites W2141116006 @default.
- W2087307714 cites W2143563119 @default.
- W2087307714 cites W2150597600 @default.
- W2087307714 cites W2156075377 @default.
- W2087307714 cites W2157512279 @default.
- W2087307714 cites W2159623504 @default.
- W2087307714 cites W2166375403 @default.
- W2087307714 cites W2168960379 @default.
- W2087307714 cites W2170636321 @default.
- W2087307714 cites W4253917748 @default.
- W2087307714 doi "https://doi.org/10.1371/journal.pone.0029260" @default.
- W2087307714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3237609" @default.
- W2087307714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22195035" @default.
- W2087307714 hasPublicationYear "2011" @default.
- W2087307714 type Work @default.
- W2087307714 sameAs 2087307714 @default.
- W2087307714 citedByCount "69" @default.
- W2087307714 countsByYear W20873077142013 @default.
- W2087307714 countsByYear W20873077142014 @default.
- W2087307714 countsByYear W20873077142015 @default.
- W2087307714 countsByYear W20873077142016 @default.
- W2087307714 countsByYear W20873077142017 @default.
- W2087307714 countsByYear W20873077142018 @default.
- W2087307714 countsByYear W20873077142019 @default.
- W2087307714 countsByYear W20873077142020 @default.
- W2087307714 countsByYear W20873077142021 @default.
- W2087307714 countsByYear W20873077142022 @default.
- W2087307714 countsByYear W20873077142023 @default.
- W2087307714 crossrefType "journal-article" @default.
- W2087307714 hasAuthorship W2087307714A5005567648 @default.
- W2087307714 hasAuthorship W2087307714A5019907039 @default.
- W2087307714 hasAuthorship W2087307714A5022196859 @default.
- W2087307714 hasAuthorship W2087307714A5047111647 @default.
- W2087307714 hasAuthorship W2087307714A5061490638 @default.
- W2087307714 hasBestOaLocation W20873077141 @default.
- W2087307714 hasConcept C135285700 @default.
- W2087307714 hasConcept C137738243 @default.
- W2087307714 hasConcept C1491633281 @default.
- W2087307714 hasConcept C170493617 @default.
- W2087307714 hasConcept C184235292 @default.
- W2087307714 hasConcept C185592680 @default.
- W2087307714 hasConcept C2776661833 @default.
- W2087307714 hasConcept C55493867 @default.
- W2087307714 hasConcept C62478195 @default.
- W2087307714 hasConcept C79879829 @default.
- W2087307714 hasConcept C86803240 @default.
- W2087307714 hasConcept C95444343 @default.
- W2087307714 hasConcept C97029542 @default.
- W2087307714 hasConceptScore W2087307714C135285700 @default.
- W2087307714 hasConceptScore W2087307714C137738243 @default.
- W2087307714 hasConceptScore W2087307714C1491633281 @default.
- W2087307714 hasConceptScore W2087307714C170493617 @default.
- W2087307714 hasConceptScore W2087307714C184235292 @default.