Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087310441> ?p ?o ?g. }
- W2087310441 endingPage "46" @default.
- W2087310441 startingPage "37" @default.
- W2087310441 abstract "Although several new therapies have recently become available for the treatment of castrate-resistant prostate cancer (CRPC), the disease remains universally incurable and demands novel therapeutic approaches. To this end, great strides have been made in our understanding of the biologic and molecular mechanisms driving prostate cancer growth and progression in the past few years, resulting in widespread clinical investigation of numerous new targeted therapies. This review will highlight some of the key therapeutic agents that (in the opinion of the authors) may have the largest effect on the future management of CRPC, with a focus on both molecular targets and clinical trial design. These agents include angiogenesis inhibitors, mTOR pathway inhibitors, apoptosis-inducing drugs, IGF pathway inhibitors, Src family inhibitors, Hedgehog pathway antagonists, epigenetic therapies, PARP inhibitors, and prodrug approaches. The future of CRPC therapy appears brighter than ever before." @default.
- W2087310441 created "2016-06-24" @default.
- W2087310441 creator A5001783218 @default.
- W2087310441 creator A5018645768 @default.
- W2087310441 date "2010-12-01" @default.
- W2087310441 modified "2023-09-25" @default.
- W2087310441 title "Future Directions in Castrate-Resistant Prostate Cancer Therapy" @default.
- W2087310441 cites W1487307409 @default.
- W2087310441 cites W159371865 @default.
- W2087310441 cites W1597238753 @default.
- W2087310441 cites W1894792990 @default.
- W2087310441 cites W1965431780 @default.
- W2087310441 cites W1967275220 @default.
- W2087310441 cites W1978103469 @default.
- W2087310441 cites W1980451446 @default.
- W2087310441 cites W1983225862 @default.
- W2087310441 cites W1984827267 @default.
- W2087310441 cites W1987570849 @default.
- W2087310441 cites W1989014008 @default.
- W2087310441 cites W1989901669 @default.
- W2087310441 cites W1991355732 @default.
- W2087310441 cites W1991541715 @default.
- W2087310441 cites W1995328364 @default.
- W2087310441 cites W1996325724 @default.
- W2087310441 cites W2003973314 @default.
- W2087310441 cites W2006333161 @default.
- W2087310441 cites W2017394727 @default.
- W2087310441 cites W2022370900 @default.
- W2087310441 cites W2035521896 @default.
- W2087310441 cites W2036245537 @default.
- W2087310441 cites W2044826176 @default.
- W2087310441 cites W2047155047 @default.
- W2087310441 cites W2048629875 @default.
- W2087310441 cites W2049820493 @default.
- W2087310441 cites W2055936726 @default.
- W2087310441 cites W2071037802 @default.
- W2087310441 cites W2076295899 @default.
- W2087310441 cites W2078416515 @default.
- W2087310441 cites W2086038769 @default.
- W2087310441 cites W2088231330 @default.
- W2087310441 cites W2091874984 @default.
- W2087310441 cites W2093107372 @default.
- W2087310441 cites W2094269170 @default.
- W2087310441 cites W2099460616 @default.
- W2087310441 cites W2099968812 @default.
- W2087310441 cites W2100970263 @default.
- W2087310441 cites W2101012300 @default.
- W2087310441 cites W2103059478 @default.
- W2087310441 cites W2108707301 @default.
- W2087310441 cites W2110321605 @default.
- W2087310441 cites W2111199038 @default.
- W2087310441 cites W2114471035 @default.
- W2087310441 cites W2115842954 @default.
- W2087310441 cites W2116005493 @default.
- W2087310441 cites W2117170342 @default.
- W2087310441 cites W2117701024 @default.
- W2087310441 cites W2118263555 @default.
- W2087310441 cites W2119402609 @default.
- W2087310441 cites W2120501943 @default.
- W2087310441 cites W2121017846 @default.
- W2087310441 cites W2125505483 @default.
- W2087310441 cites W2126504358 @default.
- W2087310441 cites W2128209976 @default.
- W2087310441 cites W2131670056 @default.
- W2087310441 cites W2132663758 @default.
- W2087310441 cites W2138405392 @default.
- W2087310441 cites W2143285371 @default.
- W2087310441 cites W2144813855 @default.
- W2087310441 cites W2151151062 @default.
- W2087310441 cites W2151635781 @default.
- W2087310441 cites W2153140330 @default.
- W2087310441 cites W2154028722 @default.
- W2087310441 cites W2155345787 @default.
- W2087310441 cites W2155851270 @default.
- W2087310441 cites W2157897307 @default.
- W2087310441 cites W2159753688 @default.
- W2087310441 cites W2166221624 @default.
- W2087310441 cites W2167494923 @default.
- W2087310441 cites W2169140729 @default.
- W2087310441 cites W2171286940 @default.
- W2087310441 cites W2171459779 @default.
- W2087310441 cites W2171972386 @default.
- W2087310441 cites W4229861519 @default.
- W2087310441 cites W4297903474 @default.
- W2087310441 cites W96337941 @default.
- W2087310441 doi "https://doi.org/10.3816/cgc.2010.n.006" @default.
- W2087310441 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4029111" @default.
- W2087310441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21208854" @default.
- W2087310441 hasPublicationYear "2010" @default.
- W2087310441 type Work @default.
- W2087310441 sameAs 2087310441 @default.
- W2087310441 citedByCount "13" @default.
- W2087310441 countsByYear W20873104412012 @default.
- W2087310441 countsByYear W20873104412013 @default.
- W2087310441 countsByYear W20873104412014 @default.
- W2087310441 countsByYear W20873104412015 @default.
- W2087310441 countsByYear W20873104412016 @default.
- W2087310441 countsByYear W20873104412017 @default.