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- W2087325036 abstract "A collection of 28 medulloblastomas was analyzed for expression of the developmental control genes PAX-6 and EN by immunohistochemical staining. Sixteen medulloblastomas expressed both EN and PAX-6 but, when differentiation could be assessed in the positive areas, PAX-6 is expressed in the less differentiated cells. Since Drosophila en encodes a negative regulator, we overexpressed the chicken en-1 in retinal pigmented epithelium cells. This resulted in Pax-6 down regulation. These results suggest a regulatory loop between PAX-6 and EN, two molecular markers of medulloblastoma." @default.
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- W2087325036 date "1996-05-01" @default.
- W2087325036 modified "2023-09-24" @default.
- W2087325036 title "Differential expression between PAX-6 and EN proteins in medulloblastoma" @default.
- W2087325036 doi "https://doi.org/10.3892/ijo.8.5.901" @default.
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