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- W2087335877 abstract "Background and Aims: Besides its known cardiac effects, cardiotrophin-1 (CT-1), a cytokine belonging to the interleukin-6 family, exerts proliferative and secretory effects in vascular smooth muscle cells. We aimed to investigate the functional and morphological vascular changes induced by chronic CT-1 administration in rats and its involvement in the arterial phenotype of CT-1-null mice in vivo. Methods: A) Recombinant rat CT-1 (20 μg/Kg, IP) was administrated to Wistar rats for six weeks (n = 10/group). Blood pressure (BP) and heart rate were recorded by telemetry. Cardiac function was assessed using PET-scan. B) 2 year-old wild-type (WT) (n = 8) and CT-1-null mice (n = 3) were studied. Vascular structure and function were evaluated by an echo-tracking device. Circumferential wall stress, incremental elastic modulus (Einc), media cross-sectional area and pulse wave velocity (PWV) were measured. Aortic wall collagen and elastin contents were determined using immunohistochemistry, and the expression of collagen type I and III, elastin and fibronectin was quantified by RT-PCR and Western blot in aortic extracts. Results: A) Neither vehicle nor CT-1 treatment modified BP. CT-1-treated rats displayed decreased cardiac output (p < 0.01) as well as wall stress (p < 0.01), Einc (p < 0.01) and PWV (p < 0.05) as compared with vehicle group. CT-1-treated rats also showed increased media cross sectional area (p < 0.01) and collagen content (p < 0.01). CT-1-overloaded rats displayed increased expression of collagen type I (p < 0.05) and III (p < 0.01) and fibronectin (p < 0.01). B) CT-1-null mice presented an increased wall stress (p < 0.05) and Einc (p < 0.05) as compared with WT mice. Media cross sectional area and collagen content were reduced (p < 0.05) in mice lacking CT-1. Conclusions: Normotensive rats subjected to CT-1 overloading developed impaired cardiac and vascular functions, characterized by an increment in arterial stiffness accompanied by an augmented media thickness and extracellular matrix production. Accordingly, CT-1-null mice presented a reduced arterial stiffness and a reduced media thickness and collagen content. Our data show that CT-1 is a key player in arterial thickness and stiffness and in the cardiovascular coupling." @default.
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- W2087335877 date "2010-06-01" @default.
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- W2087335877 title "CARDIOTROPHIN-1 IS A DETERMINANT OF ARTERIAL STIFFNESS AND THICKNESS IN RODENTS: 3A.03" @default.
- W2087335877 doi "https://doi.org/10.1097/01.hjh.0000378294.50920.e4" @default.
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