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- W2087340711 abstract "Control over ionic composition and volume of the inner ear luminal fluid endolymph is essential for normal hearing and balance. Mice deficient in either the EphB2 receptor tyrosine kinase or the cognate transmembrane ligand ephrin-B2 (Efnb2) exhibit background strain-specific vestibular-behavioral dysfunction and signs of abnormal endolymph homeostasis. Using various loss-of-function mouse models, we found that Efnb2 is required for growth and morphogenesis of the embryonic endolymphatic epithelium, a precursor of the endolymphatic sac (ES) and duct (ED), which mediate endolymph homeostasis. Conditional inactivation of Efnb2 in early-stage embryonic ear tissues disrupted cell proliferation, cell survival, and epithelial folding at the origin of the endolymphatic epithelium. This correlated with apparent absence of an ED, mis-localization of ES ion transport cells relative to inner ear sensory organs, dysplasia of the endolymph fluid space, and abnormally formed otoconia (extracellular calcite-protein composites) at later stages of embryonic development. A comparison of Efnb2 and Notch signaling-deficient mutant phenotypes indicated that these two signaling systems have distinct and non-overlapping roles in ES/ED development. Homozygous deletion of the Efnb2 C-terminus caused abnormalities similar to those found in the conditional Efnb2 null homozygote. Analyses of fetal Efnb2 C-terminus deletion heterozygotes found mis-localized ES ion transport cells only in the genetic background exhibiting vestibular dysfunction. We propose that developmental dysplasias described here are a gene dose-sensitive cause of the vestibular dysfunction observed in EphB-Efnb2 signaling-deficient mice." @default.
- W2087340711 created "2016-06-24" @default.
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- W2087340711 date "2014-06-01" @default.
- W2087340711 modified "2023-09-25" @default.
- W2087340711 title "Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear" @default.
- W2087340711 cites W124696608 @default.
- W2087340711 cites W1581489141 @default.
- W2087340711 cites W1971403829 @default.
- W2087340711 cites W1972814800 @default.
- W2087340711 cites W1976915484 @default.
- W2087340711 cites W1978105135 @default.
- W2087340711 cites W1979953012 @default.
- W2087340711 cites W1986262294 @default.
- W2087340711 cites W1987466584 @default.
- W2087340711 cites W1991760840 @default.
- W2087340711 cites W2000843253 @default.
- W2087340711 cites W2004820918 @default.
- W2087340711 cites W2010144039 @default.
- W2087340711 cites W2010638985 @default.
- W2087340711 cites W2011282282 @default.
- W2087340711 cites W2015863739 @default.
- W2087340711 cites W2022178351 @default.
- W2087340711 cites W2024385388 @default.
- W2087340711 cites W2029189567 @default.
- W2087340711 cites W2032184616 @default.
- W2087340711 cites W2035087409 @default.
- W2087340711 cites W2035595755 @default.
- W2087340711 cites W2035690763 @default.
- W2087340711 cites W2038894508 @default.
- W2087340711 cites W2041216520 @default.
- W2087340711 cites W2042645208 @default.
- W2087340711 cites W2046881486 @default.
- W2087340711 cites W2046892512 @default.
- W2087340711 cites W2048285926 @default.
- W2087340711 cites W2054493690 @default.
- W2087340711 cites W2056204692 @default.
- W2087340711 cites W2059535841 @default.
- W2087340711 cites W2059938560 @default.
- W2087340711 cites W2062408585 @default.
- W2087340711 cites W2062544120 @default.
- W2087340711 cites W2065987736 @default.
- W2087340711 cites W2066500575 @default.
- W2087340711 cites W2066607065 @default.
- W2087340711 cites W2071254903 @default.
- W2087340711 cites W2075199885 @default.
- W2087340711 cites W2075815038 @default.
- W2087340711 cites W2080493586 @default.
- W2087340711 cites W2082476939 @default.
- W2087340711 cites W2085595067 @default.
- W2087340711 cites W2086165647 @default.
- W2087340711 cites W2089031748 @default.
- W2087340711 cites W2089946206 @default.
- W2087340711 cites W2090791264 @default.
- W2087340711 cites W2100039503 @default.
- W2087340711 cites W2102326129 @default.
- W2087340711 cites W2102991987 @default.
- W2087340711 cites W2103852413 @default.
- W2087340711 cites W2108212727 @default.
- W2087340711 cites W2112149927 @default.
- W2087340711 cites W2113347813 @default.
- W2087340711 cites W2118987870 @default.
- W2087340711 cites W2121276197 @default.
- W2087340711 cites W2121854884 @default.
- W2087340711 cites W2124521784 @default.
- W2087340711 cites W2128942479 @default.
- W2087340711 cites W2129132759 @default.
- W2087340711 cites W2133943800 @default.
- W2087340711 cites W2135144225 @default.
- W2087340711 cites W2140828631 @default.
- W2087340711 cites W2142399350 @default.
- W2087340711 cites W2147957869 @default.
- W2087340711 cites W2148339830 @default.
- W2087340711 cites W2150149878 @default.
- W2087340711 cites W2152285563 @default.
- W2087340711 cites W2152297969 @default.
- W2087340711 cites W2153044032 @default.
- W2087340711 cites W2153527056 @default.
- W2087340711 cites W2157941481 @default.
- W2087340711 cites W2161867220 @default.
- W2087340711 cites W2164110225 @default.
- W2087340711 cites W2184559181 @default.
- W2087340711 cites W2317457028 @default.
- W2087340711 cites W3147187474 @default.
- W2087340711 doi "https://doi.org/10.1016/j.ydbio.2014.02.019" @default.
- W2087340711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4113727" @default.
- W2087340711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24583262" @default.
- W2087340711 hasPublicationYear "2014" @default.
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