FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087362148> ?p ?o ?g. }

• W2087362148 endingPage "594" @default.
• W2087362148 startingPage "587" @default.
• W2087362148 abstract "In the last few years tobacco companies have been developing several research strategies in order to reduce the risks associated with smoking. These strategies include, for example, the refining of alternative cigarette designs that reduce the amount of hazardous chemicals in the mainstream smoke by introducing modified filters, and/or reducing the amount of biologically significant ingredients in tobacco-burning cigarettes. In the last few decades numerous studies have been published to assess the biological activity of tobacco smoke using in vivo and in vitro test systems. In this scenario a general scientific consensus on how to measure and characterize the risk associated with cigarette smoke is still lacking. Short-term in vitro assays, which are widely accepted by regulatory agencies around the world, are useful tools to evaluate both the biological activity and the progress towards a reduction of tobacco smoke toxicity. These assays could be mainly applied to evaluate cytotoxicity and genotoxicity properties on whole cigarette smoke as well as condensates or fractions of whole smoke. Cytotoxicity induction can be measured as cellular viability and growth rates using different end-points. Otherwise, the target of genotoxicity studies is the DNA molecule. For genotoxicity evaluation, the end-points and cell systems should be chosen from those that are relevant and appropriate as clinical surrogate markers. In this respect, the occurrence of early biological effect markers, such as mutational or clastogenic events (point mutations, frameshifts, micronuclei, SCE, DNA adducts) in bacterial and mammalian cells should be studied in a tiered approach following the guidelines of regulatory agencies. The choice of criteria shall be matter of discussion." @default.
• W2087362148 created "2016-06-24" @default.
• W2087362148 creator A5040010552 @default.
• W2087362148 creator A5065290400 @default.
• W2087362148 creator A5081610391 @default.
• W2087362148 date "2003-10-01" @default.
• W2087362148 modified "2023-09-23" @default.
• W2087362148 title "A review of in vitro methods to assess the biological activity of tobacco smoke with the aim of reducing the toxicity of smoke" @default.
• W2087362148 cites W1501404958 @default.
• W2087362148 cites W1573222389 @default.
• W2087362148 cites W1706252352 @default.
• W2087362148 cites W1965433424 @default.
• W2087362148 cites W1965535479 @default.
• W2087362148 cites W1969522820 @default.
• W2087362148 cites W1971711213 @default.
• W2087362148 cites W1973195696 @default.
• W2087362148 cites W1973879072 @default.
• W2087362148 cites W1976917904 @default.
• W2087362148 cites W1979932284 @default.
• W2087362148 cites W1983937034 @default.
• W2087362148 cites W1989060317 @default.
• W2087362148 cites W1991732738 @default.
• W2087362148 cites W1998700528 @default.
• W2087362148 cites W2007508989 @default.
• W2087362148 cites W2008838636 @default.
• W2087362148 cites W2014569226 @default.
• W2087362148 cites W2017788986 @default.
• W2087362148 cites W2018984280 @default.
• W2087362148 cites W2023050106 @default.
• W2087362148 cites W2024264346 @default.
• W2087362148 cites W2027631709 @default.
• W2087362148 cites W2037433191 @default.
• W2087362148 cites W2041830360 @default.
• W2087362148 cites W2051047340 @default.
• W2087362148 cites W2052492048 @default.
• W2087362148 cites W2055294823 @default.
• W2087362148 cites W2060906448 @default.
• W2087362148 cites W2073093751 @default.
• W2087362148 cites W2073445049 @default.
• W2087362148 cites W2075174342 @default.
• W2087362148 cites W2078386567 @default.
• W2087362148 cites W2080923051 @default.
• W2087362148 cites W2086394721 @default.
• W2087362148 cites W2088682951 @default.
• W2087362148 cites W2089874471 @default.
• W2087362148 cites W2098883242 @default.
• W2087362148 cites W2099519779 @default.
• W2087362148 cites W2105758670 @default.
• W2087362148 cites W2107993738 @default.
• W2087362148 cites W2126136513 @default.
• W2087362148 cites W2147842463 @default.
• W2087362148 cites W2154481925 @default.
• W2087362148 cites W2155765103 @default.
• W2087362148 cites W2211538826 @default.
• W2087362148 cites W2263428352 @default.
• W2087362148 cites W2469395059 @default.
• W2087362148 cites W3213430168 @default.
• W2087362148 cites W4211138481 @default.
• W2087362148 cites W4233738575 @default.
• W2087362148 doi "https://doi.org/10.1016/s0887-2333(03)00091-2" @default.
• W2087362148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14599449" @default.
• W2087362148 hasPublicationYear "2003" @default.
• W2087362148 type Work @default.
• W2087362148 sameAs 2087362148 @default.
• W2087362148 citedByCount "91" @default.
• W2087362148 countsByYear W20873621482012 @default.
• W2087362148 countsByYear W20873621482013 @default.
• W2087362148 countsByYear W20873621482014 @default.
• W2087362148 countsByYear W20873621482015 @default.
• W2087362148 countsByYear W20873621482016 @default.
• W2087362148 countsByYear W20873621482017 @default.
• W2087362148 countsByYear W20873621482018 @default.
• W2087362148 countsByYear W20873621482019 @default.
• W2087362148 countsByYear W20873621482020 @default.
• W2087362148 countsByYear W20873621482021 @default.
• W2087362148 countsByYear W20873621482022 @default.
• W2087362148 countsByYear W20873621482023 @default.
• W2087362148 crossrefType "journal-article" @default.
• W2087362148 hasAuthorship W2087362148A5040010552 @default.
• W2087362148 hasAuthorship W2087362148A5065290400 @default.
• W2087362148 hasAuthorship W2087362148A5081610391 @default.
• W2087362148 hasConcept C129990765 @default.
• W2087362148 hasConcept C141710004 @default.
• W2087362148 hasConcept C150903083 @default.
• W2087362148 hasConcept C178790620 @default.
• W2087362148 hasConcept C185592680 @default.
• W2087362148 hasConcept C207001950 @default.
• W2087362148 hasConcept C2778355491 @default.
• W2087362148 hasConcept C2778959862 @default.
• W2087362148 hasConcept C29730261 @default.
• W2087362148 hasConcept C2993351451 @default.
• W2087362148 hasConcept C33070731 @default.
• W2087362148 hasConcept C33618052 @default.
• W2087362148 hasConcept C45080847 @default.
• W2087362148 hasConcept C58874564 @default.
• W2087362148 hasConcept C70721500 @default.
• W2087362148 hasConcept C71924100 @default.
• W2087362148 hasConcept C86803240 @default.

• next