FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087366311> ?p ?o ?g. }

• W2087366311 endingPage "1422" @default.
• W2087366311 startingPage "1411" @default.
• W2087366311 abstract "The rapid reactions of nitrosoarenes with cellular SH groups have proved to be main metabolic conversions during detoxication. Interactions of the phenacetin metabolite 4-nitrosophenetole with glutathione have been investigated in detail during the last years, revealing a complex pattern of products depending on the stoichiometry of the reactants and reaction conditions. Eight metabolites have been identified hitherto, and the present work extends this medley by six additional products. Three metastable sulfenamides, 4-ethoxy-2,N-bis(glutathion-S-yl)-aniline, N4-(glutathion-S-yl)-4-amino-4‘-ethoxydiphenylamine, and N-(glutathion-S-yl)-4-aminophenol, as well as the N-sulfenylquinonimine N-(glutathion-S-yl)-1,4-benzoquinonimine were characterized by chemical reactivity, chromatographic behavior, UV/vis absorption, 1H NMR, and FAB-MS data. The structure of the sulfenamide 2,N4-bis(glutathion-S-yl)-4-amino-4‘-ethoxydiphenylamine could not be proved unequivocally, but is strongly suggested due to the chemical reactivity, chromatographic behavior, and UV/vis absorption of the compound. Finally, traces of 4-aminophenol were detected. A reaction scheme is presented explaining the formation of all identified metabolites via a central sulfenamide cation. Molecular orbital calculations for this sulfenamide cation have been performed, corroborating the proposed reaction mechanisms on the basis of Klopman's generalized perturbation theory." @default.
• W2087366311 created "2016-06-24" @default.
• W2087366311 creator A5000204004 @default.
• W2087366311 creator A5023150581 @default.
• W2087366311 creator A5030198092 @default.
• W2087366311 creator A5033594278 @default.
• W2087366311 creator A5033972829 @default.
• W2087366311 creator A5038150072 @default.
• W2087366311 creator A5057422891 @default.
• W2087366311 creator A5089376775 @default.
• W2087366311 date "1998-12-01" @default.
• W2087366311 modified "2023-09-27" @default.
• W2087366311 title "Additional Pathways ofS-Conjugate Formation during Interaction of 4-Nitrosophenetole with Glutathione" @default.
• W2087366311 cites W1970437906 @default.
• W2087366311 cites W1985702903 @default.
• W2087366311 cites W1989818344 @default.
• W2087366311 cites W1990719402 @default.
• W2087366311 cites W1992658247 @default.
• W2087366311 cites W1993137057 @default.
• W2087366311 cites W1994042172 @default.
• W2087366311 cites W1994469279 @default.
• W2087366311 cites W2007544197 @default.
• W2087366311 cites W2013543512 @default.
• W2087366311 cites W2019153308 @default.
• W2087366311 cites W2023266832 @default.
• W2087366311 cites W2046629157 @default.
• W2087366311 cites W2050218133 @default.
• W2087366311 cites W2072922607 @default.
• W2087366311 cites W2088314021 @default.
• W2087366311 cites W2088870966 @default.
• W2087366311 cites W2091692227 @default.
• W2087366311 cites W2093793222 @default.
• W2087366311 cites W2101189757 @default.
• W2087366311 cites W2119212447 @default.
• W2087366311 cites W2950158176 @default.
• W2087366311 cites W2953334713 @default.
• W2087366311 doi "https://doi.org/10.1021/tx980087q" @default.
• W2087366311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9860482" @default.
• W2087366311 hasPublicationYear "1998" @default.
• W2087366311 type Work @default.
• W2087366311 sameAs 2087366311 @default.
• W2087366311 citedByCount "5" @default.
• W2087366311 countsByYear W20873663112019 @default.
• W2087366311 crossrefType "journal-article" @default.
• W2087366311 hasAuthorship W2087366311A5000204004 @default.
• W2087366311 hasAuthorship W2087366311A5023150581 @default.
• W2087366311 hasAuthorship W2087366311A5030198092 @default.
• W2087366311 hasAuthorship W2087366311A5033594278 @default.
• W2087366311 hasAuthorship W2087366311A5033972829 @default.
• W2087366311 hasAuthorship W2087366311A5038150072 @default.
• W2087366311 hasAuthorship W2087366311A5057422891 @default.
• W2087366311 hasAuthorship W2087366311A5089376775 @default.
• W2087366311 hasConcept C134306372 @default.
• W2087366311 hasConcept C142724271 @default.
• W2087366311 hasConcept C147597530 @default.
• W2087366311 hasConcept C155647269 @default.
• W2087366311 hasConcept C161790260 @default.
• W2087366311 hasConcept C176933379 @default.
• W2087366311 hasConcept C178790620 @default.
• W2087366311 hasConcept C181199279 @default.
• W2087366311 hasConcept C185592680 @default.
• W2087366311 hasConcept C192937433 @default.
• W2087366311 hasConcept C197336794 @default.
• W2087366311 hasConcept C204787440 @default.
• W2087366311 hasConcept C2775932965 @default.
• W2087366311 hasConcept C2776910235 @default.
• W2087366311 hasConcept C2778435939 @default.
• W2087366311 hasConcept C2779201268 @default.
• W2087366311 hasConcept C2779244968 @default.
• W2087366311 hasConcept C33923547 @default.
• W2087366311 hasConcept C51179264 @default.
• W2087366311 hasConcept C538909803 @default.
• W2087366311 hasConcept C71240020 @default.
• W2087366311 hasConcept C71924100 @default.
• W2087366311 hasConceptScore W2087366311C134306372 @default.
• W2087366311 hasConceptScore W2087366311C142724271 @default.
• W2087366311 hasConceptScore W2087366311C147597530 @default.
• W2087366311 hasConceptScore W2087366311C155647269 @default.
• W2087366311 hasConceptScore W2087366311C161790260 @default.
• W2087366311 hasConceptScore W2087366311C176933379 @default.
• W2087366311 hasConceptScore W2087366311C178790620 @default.
• W2087366311 hasConceptScore W2087366311C181199279 @default.
• W2087366311 hasConceptScore W2087366311C185592680 @default.
• W2087366311 hasConceptScore W2087366311C192937433 @default.
• W2087366311 hasConceptScore W2087366311C197336794 @default.
• W2087366311 hasConceptScore W2087366311C204787440 @default.
• W2087366311 hasConceptScore W2087366311C2775932965 @default.
• W2087366311 hasConceptScore W2087366311C2776910235 @default.
• W2087366311 hasConceptScore W2087366311C2778435939 @default.
• W2087366311 hasConceptScore W2087366311C2779201268 @default.
• W2087366311 hasConceptScore W2087366311C2779244968 @default.
• W2087366311 hasConceptScore W2087366311C33923547 @default.
• W2087366311 hasConceptScore W2087366311C51179264 @default.
• W2087366311 hasConceptScore W2087366311C538909803 @default.
• W2087366311 hasConceptScore W2087366311C71240020 @default.
• W2087366311 hasConceptScore W2087366311C71924100 @default.
• W2087366311 hasIssue "12" @default.
• W2087366311 hasLocation W20873663111 @default.

• next