FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087372220> ?p ?o ?g. }

• W2087372220 endingPage "155" @default.
• W2087372220 startingPage "148" @default.
• W2087372220 abstract "Muscarinic acetylcholine receptors (mAChRs) have long been viewed as viable targets for novel therapeutic agents for the treatment of Alzheimer's disease (AD) and other disorders involving impaired cognitive function. More recent evidence indicates that mAChR activators might also have utility in treating psychosis and other symptoms associated with schizophrenia and other central nervous system (CNS) disorders. Efforts to develop mAChR subtype-selective agonists have been hampered by difficulty in achieving high selectivity for individual mAChR subtypes important for CNS function (M1 and M4) and adverse effects due to activation of peripheral mAChRs (especially M2 and M3). Major advances have now been achieved in the discovery of allosteric agonists and positive allosteric modulators of M1 and M4 that show greater selectivity for individual mAChR subtypes than do previous mAChR agonists. Early studies indicate that these allosteric mAChR activators have properties needed for optimization as potential clinical candidates and have robust effects in animal models that predict efficacy in the treatment of AD, schizophrenia and related disorders. Muscarinic acetylcholine receptors (mAChRs) have long been viewed as viable targets for novel therapeutic agents for the treatment of Alzheimer's disease (AD) and other disorders involving impaired cognitive function. More recent evidence indicates that mAChR activators might also have utility in treating psychosis and other symptoms associated with schizophrenia and other central nervous system (CNS) disorders. Efforts to develop mAChR subtype-selective agonists have been hampered by difficulty in achieving high selectivity for individual mAChR subtypes important for CNS function (M1 and M4) and adverse effects due to activation of peripheral mAChRs (especially M2 and M3). Major advances have now been achieved in the discovery of allosteric agonists and positive allosteric modulators of M1 and M4 that show greater selectivity for individual mAChR subtypes than do previous mAChR agonists. Early studies indicate that these allosteric mAChR activators have properties needed for optimization as potential clinical candidates and have robust effects in animal models that predict efficacy in the treatment of AD, schizophrenia and related disorders." @default.
• W2087372220 created "2016-06-24" @default.
• W2087372220 creator A5026609125 @default.
• W2087372220 creator A5051209585 @default.
• W2087372220 creator A5060483072 @default.
• W2087372220 date "2009-03-01" @default.
• W2087372220 modified "2023-10-12" @default.
• W2087372220 title "Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders" @default.
• W2087372220 cites W1875675415 @default.
• W2087372220 cites W1946525928 @default.
• W2087372220 cites W1963693349 @default.
• W2087372220 cites W1964576814 @default.
• W2087372220 cites W1966014791 @default.
• W2087372220 cites W1977892449 @default.
• W2087372220 cites W1987358117 @default.
• W2087372220 cites W1987451426 @default.
• W2087372220 cites W1999774383 @default.
• W2087372220 cites W1999799735 @default.
• W2087372220 cites W2003736358 @default.
• W2087372220 cites W2006909079 @default.
• W2087372220 cites W2012286072 @default.
• W2087372220 cites W2016278859 @default.
• W2087372220 cites W2023796931 @default.
• W2087372220 cites W2036398723 @default.
• W2087372220 cites W2040152110 @default.
• W2087372220 cites W2043923237 @default.
• W2087372220 cites W2048264021 @default.
• W2087372220 cites W2049583304 @default.
• W2087372220 cites W2050688876 @default.
• W2087372220 cites W2051166675 @default.
• W2087372220 cites W2053696585 @default.
• W2087372220 cites W2060372151 @default.
• W2087372220 cites W2067418199 @default.
• W2087372220 cites W2077484959 @default.
• W2087372220 cites W2081792830 @default.
• W2087372220 cites W2096830703 @default.
• W2087372220 cites W2098782685 @default.
• W2087372220 cites W2099379810 @default.
• W2087372220 cites W2111966973 @default.
• W2087372220 cites W2116719688 @default.
• W2087372220 cites W2119698606 @default.
• W2087372220 cites W2137248376 @default.
• W2087372220 cites W2142903182 @default.
• W2087372220 cites W2144750899 @default.
• W2087372220 cites W2149860378 @default.
• W2087372220 cites W2150063046 @default.
• W2087372220 cites W2160475276 @default.
• W2087372220 cites W2161088063 @default.
• W2087372220 cites W2161373416 @default.
• W2087372220 cites W2161877489 @default.
• W2087372220 cites W2170692825 @default.
• W2087372220 cites W2473974687 @default.
• W2087372220 cites W3025891904 @default.
• W2087372220 doi "https://doi.org/10.1016/j.tips.2008.12.002" @default.
• W2087372220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2907736" @default.
• W2087372220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19201489" @default.
• W2087372220 hasPublicationYear "2009" @default.
• W2087372220 type Work @default.
• W2087372220 sameAs 2087372220 @default.
• W2087372220 citedByCount "254" @default.
• W2087372220 countsByYear W20873722202012 @default.
• W2087372220 countsByYear W20873722202013 @default.
• W2087372220 countsByYear W20873722202014 @default.
• W2087372220 countsByYear W20873722202015 @default.
• W2087372220 countsByYear W20873722202016 @default.
• W2087372220 countsByYear W20873722202017 @default.
• W2087372220 countsByYear W20873722202018 @default.
• W2087372220 countsByYear W20873722202019 @default.
• W2087372220 countsByYear W20873722202020 @default.
• W2087372220 countsByYear W20873722202021 @default.
• W2087372220 countsByYear W20873722202022 @default.
• W2087372220 countsByYear W20873722202023 @default.
• W2087372220 crossrefType "journal-article" @default.
• W2087372220 hasAuthorship W2087372220A5026609125 @default.
• W2087372220 hasAuthorship W2087372220A5051209585 @default.
• W2087372220 hasAuthorship W2087372220A5060483072 @default.
• W2087372220 hasBestOaLocation W20873722202 @default.
• W2087372220 hasConcept C118552586 @default.
• W2087372220 hasConcept C126322002 @default.
• W2087372220 hasConcept C15744967 @default.
• W2087372220 hasConcept C166342909 @default.
• W2087372220 hasConcept C169760540 @default.
• W2087372220 hasConcept C170493617 @default.
• W2087372220 hasConcept C2775910092 @default.
• W2087372220 hasConcept C2776038425 @default.
• W2087372220 hasConcept C2776412080 @default.
• W2087372220 hasConcept C2779727114 @default.
• W2087372220 hasConcept C33789571 @default.
• W2087372220 hasConcept C529278444 @default.
• W2087372220 hasConcept C71924100 @default.
• W2087372220 hasConcept C98274493 @default.
• W2087372220 hasConceptScore W2087372220C118552586 @default.
• W2087372220 hasConceptScore W2087372220C126322002 @default.
• W2087372220 hasConceptScore W2087372220C15744967 @default.
• W2087372220 hasConceptScore W2087372220C166342909 @default.
• W2087372220 hasConceptScore W2087372220C169760540 @default.
• W2087372220 hasConceptScore W2087372220C170493617 @default.
• W2087372220 hasConceptScore W2087372220C2775910092 @default.

• next