FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087380070> ?p ?o ?g. }

• W2087380070 endingPage "57" @default.
• W2087380070 startingPage "49" @default.
• W2087380070 abstract "Heavy and light chain variable region nucleotide sequences were derived from 6 human hybridoma antibodies which bear characteristics of antibodies associated with the phospholipid antibody syndrome. All antibodies originated from non-autoimmune individuals and were polyspecific. Four of these reacted with cardiolipin (and other antigens) and three carried the H3 idiotype which is expressed on a high percentage of disease-associated anti-cardiolipin antibodies. This idiotype was localized to the lambda light chain of the H3 monoclonal antibody and found on two other antibodies which like H3 expressed Vλ4 or the related Vλ3 subgroup light chains. The H3 idiotype however did not define these subgroups nor was it required or sufficient for anti-cardiolipin activity. Anticardiolipin binding was found in VH1, VH3 and VH4 heavy chain families and in a Vk1 light chain. The D region was diverse in both length and gene usage. Although all cardiolipin binding antibodies showed little deviation from germline variable (V) gene sequences, where mutations occurred they tended to be replacement mutations and clustered in complementarity determining regions (CDR) suggesting these B cells were derived from antigen-driven responses. These results from our panel of hybridomas and their comparison to other human antibodies provide extensive information on the diversity of genetic elements which can be used by cardiolipin-binding antibodies. We also show gene sequences which encode the disease-associated H3 idiotype and its location on lambda light chains, which imply that some labda light chains may be preferentially utilized in auto-reactive hybridomas." @default.
• W2087380070 created "2016-06-24" @default.
• W2087380070 creator A5001944753 @default.
• W2087380070 creator A5049992927 @default.
• W2087380070 creator A5056144027 @default.
• W2087380070 creator A5072347134 @default.
• W2087380070 creator A5089808423 @default.
• W2087380070 date "1995-01-01" @default.
• W2087380070 modified "2023-10-17" @default.
• W2087380070 title "Immunoglobulin Gene Sequence Anlaysis of Anti-Cardiolipin and Anti-Cardiolipin Idiotype (H3) Human Monoglonal Antibodies" @default.
• W2087380070 cites W1546739249 @default.
• W2087380070 cites W1549258100 @default.
• W2087380070 cites W1583479835 @default.
• W2087380070 cites W161233626 @default.
• W2087380070 cites W1692714928 @default.
• W2087380070 cites W1964503791 @default.
• W2087380070 cites W1968757041 @default.
• W2087380070 cites W1973107491 @default.
• W2087380070 cites W1975654480 @default.
• W2087380070 cites W1975906233 @default.
• W2087380070 cites W1981433663 @default.
• W2087380070 cites W1986269280 @default.
• W2087380070 cites W1994390883 @default.
• W2087380070 cites W2000231159 @default.
• W2087380070 cites W2010664601 @default.
• W2087380070 cites W2012271760 @default.
• W2087380070 cites W2012560194 @default.
• W2087380070 cites W2013904418 @default.
• W2087380070 cites W2014128510 @default.
• W2087380070 cites W2025140471 @default.
• W2087380070 cites W2027102035 @default.
• W2087380070 cites W2030220144 @default.
• W2087380070 cites W2033183720 @default.
• W2087380070 cites W2034271713 @default.
• W2087380070 cites W2035158781 @default.
• W2087380070 cites W2050591560 @default.
• W2087380070 cites W2057906215 @default.
• W2087380070 cites W2064729133 @default.
• W2087380070 cites W2076497788 @default.
• W2087380070 cites W2076899085 @default.
• W2087380070 cites W2077571642 @default.
• W2087380070 cites W2082451158 @default.
• W2087380070 cites W2083363168 @default.
• W2087380070 cites W2085881249 @default.
• W2087380070 cites W2089020232 @default.
• W2087380070 cites W2094037190 @default.
• W2087380070 cites W2102566053 @default.
• W2087380070 cites W2103470182 @default.
• W2087380070 cites W2109656144 @default.
• W2087380070 cites W2116393952 @default.
• W2087380070 cites W2119832072 @default.
• W2087380070 cites W2120399809 @default.
• W2087380070 cites W2126217734 @default.
• W2087380070 cites W2134755638 @default.
• W2087380070 cites W2136917720 @default.
• W2087380070 cites W2143317827 @default.
• W2087380070 cites W2146410922 @default.
• W2087380070 cites W2150633410 @default.
• W2087380070 cites W2151902818 @default.
• W2087380070 cites W2164444189 @default.
• W2087380070 cites W2209800418 @default.
• W2087380070 cites W2407906249 @default.
• W2087380070 cites W2785460813 @default.
• W2087380070 doi "https://doi.org/10.3109/08916939508995299" @default.
• W2087380070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8882422" @default.
• W2087380070 hasPublicationYear "1995" @default.
• W2087380070 type Work @default.
• W2087380070 sameAs 2087380070 @default.
• W2087380070 citedByCount "14" @default.
• W2087380070 countsByYear W20873800702012 @default.
• W2087380070 countsByYear W20873800702014 @default.
• W2087380070 countsByYear W20873800702017 @default.
• W2087380070 crossrefType "journal-article" @default.
• W2087380070 hasAuthorship W2087380070A5001944753 @default.
• W2087380070 hasAuthorship W2087380070A5049992927 @default.
• W2087380070 hasAuthorship W2087380070A5056144027 @default.
• W2087380070 hasAuthorship W2087380070A5072347134 @default.
• W2087380070 hasAuthorship W2087380070A5089808423 @default.
• W2087380070 hasConcept C104317684 @default.
• W2087380070 hasConcept C147483822 @default.
• W2087380070 hasConcept C153911025 @default.
• W2087380070 hasConcept C159654299 @default.
• W2087380070 hasConcept C203014093 @default.
• W2087380070 hasConcept C2778918659 @default.
• W2087380070 hasConcept C2781302388 @default.
• W2087380070 hasConcept C2910082366 @default.
• W2087380070 hasConcept C2910693471 @default.
• W2087380070 hasConcept C36394416 @default.
• W2087380070 hasConcept C41625074 @default.
• W2087380070 hasConcept C542903549 @default.
• W2087380070 hasConcept C54355233 @default.
• W2087380070 hasConcept C74505204 @default.
• W2087380070 hasConcept C85630698 @default.
• W2087380070 hasConcept C86803240 @default.
• W2087380070 hasConcept C96007430 @default.
• W2087380070 hasConceptScore W2087380070C104317684 @default.
• W2087380070 hasConceptScore W2087380070C147483822 @default.
• W2087380070 hasConceptScore W2087380070C153911025 @default.

• next