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- W2087398506 endingPage "521" @default.
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- W2087398506 abstract "Mitochondria play an essential role in the regulation of vascular smooth muscle Ca2+ signaling being simultaneously integrated in the regulation of ion channels and Ca2+ transporters, oxygen radical production, metabolite recycling and intracellular redox potential. Mitochondria buffer Ca2+ from cytoplasmic microdomains to alter the spatio-temporal pattern of Ca2+ gradients following Ca2+-influx and Ca2+-release, and thus control site-specific, Ca2+-dependant ion channel activation and inactivation. The sub-cellular localization of mitochondria in conjunction with tissue-specific channel expression is fundamental to vascular heterogeneity. The mitochondrial electron transport chain recycles metabolic intermediates that modulate cellular redox potential and produces oxygen radicals in proportion to oxygen tension. Perturbation of specific complexes within the transport chain can affects NADH:NAD and ATP:ADP ratios and radical production, which can in turn influence second messenger metabolism, ion channel gating and Ca2+-transporter activity. Mitochondria thus provide the common ground for cross-talk between these regulatory systems that are mutually sensitive to one another. This cross-talk between signaling systems provides a means to render the physiological regulation of vascular tone responsive to complex stimulation by paracrine and endocrine factors, blood pressure and flow, tissue oxygenation and metabolic state." @default.
- W2087398506 created "2016-06-24" @default.
- W2087398506 creator A5019198824 @default.
- W2087398506 creator A5026729348 @default.
- W2087398506 creator A5074849578 @default.
- W2087398506 date "2004-06-01" @default.
- W2087398506 modified "2023-10-18" @default.
- W2087398506 title "Vascular smooth muscle mitochondria at the cross roads of Ca2+ regulation" @default.
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