FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087401867> ?p ?o ?g. }

• W2087401867 endingPage "379" @default.
• W2087401867 startingPage "359" @default.
• W2087401867 abstract "Apoptosis is a word originally introduced by Kerr, Wyllie, and colleagues for a cell death process they defined in terms of its ultrastructural appearance in nonneuronal cells from various tissues. There are very few studies providing detailed ultrastructural criteria for recognizing neuronal apoptosis in the in vivo mammalian brain. In the absence of such criteria, the Kerr/Wyllie description pertaining to nonneuronal cells has served as a reference standard. However, contemporary neurobiologists typically rely on cell culture models for studying neuronal apoptosis, and these models are rarely validated ultrastructurally; rather they are assumed to be appropriate models based on unvalidated biochemical tests for apoptosis. Relying on evidence generated in such cell culture models or on nonspecific cytochemical tests applied to brain tissue, many authors have recently suggested that an apoptotic mechanism may mediate neuronal death in a wide variety of human neurodegenerative diseases. Whether the cell death process in neurodegenerative diseases meets ultrastructural criteria for apoptosis has been given very little consideration. Recently, several methods have been described for triggering extensive apoptotic neurodegeneration in the developing in vivo mammalian brain. These methods include head trauma or treatment with several types of drugs (NMDA antagonists, GABAA agonists, or ethanol). We have performed an ultrastructural analysis of the neuronal cell death process triggered in the cerebral cortex and thalamus by these several methods and compared it with physiological cell death (PCD), a prototypic example of neuronal apoptosis that occurs naturally in the developing brain. Our findings, which are reviewed herein, demonstrate that the types and sequence of changes induced by each of the above methods are identical to those that characterize PCD. This confirms that each of these methods produces bona fide in vivo apoptotic neurodegeneration, and it signifies that our description of this neuronal apoptotic process, which differs in some respects from the Kerr/Wyllie description of nonneuronal apoptosis, can serve as a useful reference standard for recognizing the characteristic changes that in vivo neurons undergo when they are dying by an apoptotic mechanism." @default.
• W2087401867 created "2016-06-24" @default.
• W2087401867 creator A5011324497 @default.
• W2087401867 creator A5014470968 @default.
• W2087401867 creator A5024754671 @default.
• W2087401867 creator A5047762877 @default.
• W2087401867 creator A5063105876 @default.
• W2087401867 creator A5069821756 @default.
• W2087401867 creator A5083004906 @default.
• W2087401867 date "2001-06-01" @default.
• W2087401867 modified "2023-10-14" @default.
• W2087401867 title "Apoptosis in the in Vivo Mammalian Forebrain" @default.
• W2087401867 cites W1534709134 @default.
• W2087401867 cites W1589415602 @default.
• W2087401867 cites W1613986623 @default.
• W2087401867 cites W1900368273 @default.
• W2087401867 cites W1970863115 @default.
• W2087401867 cites W1971335269 @default.
• W2087401867 cites W1972028705 @default.
• W2087401867 cites W1973541476 @default.
• W2087401867 cites W1979176029 @default.
• W2087401867 cites W1983668432 @default.
• W2087401867 cites W1987469323 @default.
• W2087401867 cites W1987808828 @default.
• W2087401867 cites W1989808869 @default.
• W2087401867 cites W1991309822 @default.
• W2087401867 cites W1991865867 @default.
• W2087401867 cites W1992517901 @default.
• W2087401867 cites W1993411918 @default.
• W2087401867 cites W2001493330 @default.
• W2087401867 cites W2015317527 @default.
• W2087401867 cites W2020034163 @default.
• W2087401867 cites W2030621950 @default.
• W2087401867 cites W2031894292 @default.
• W2087401867 cites W2036650593 @default.
• W2087401867 cites W2036778121 @default.
• W2087401867 cites W2037707710 @default.
• W2087401867 cites W2047649942 @default.
• W2087401867 cites W2050636602 @default.
• W2087401867 cites W2052853635 @default.
• W2087401867 cites W2053411770 @default.
• W2087401867 cites W2057643090 @default.
• W2087401867 cites W2076485801 @default.
• W2087401867 cites W2079787007 @default.
• W2087401867 cites W2083407432 @default.
• W2087401867 cites W2085792129 @default.
• W2087401867 cites W2089408469 @default.
• W2087401867 cites W2090522280 @default.
• W2087401867 cites W2092808670 @default.
• W2087401867 cites W2092982929 @default.
• W2087401867 cites W2097293665 @default.
• W2087401867 cites W2138302361 @default.
• W2087401867 cites W2140233572 @default.
• W2087401867 cites W2162665706 @default.
• W2087401867 cites W2316145923 @default.
• W2087401867 cites W4211045864 @default.
• W2087401867 cites W4245193385 @default.
• W2087401867 doi "https://doi.org/10.1006/nbdi.2001.0411" @default.
• W2087401867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11447994" @default.
• W2087401867 hasPublicationYear "2001" @default.
• W2087401867 type Work @default.
• W2087401867 sameAs 2087401867 @default.
• W2087401867 citedByCount "158" @default.
• W2087401867 countsByYear W20874018672012 @default.
• W2087401867 countsByYear W20874018672013 @default.
• W2087401867 countsByYear W20874018672014 @default.
• W2087401867 countsByYear W20874018672015 @default.
• W2087401867 countsByYear W20874018672016 @default.
• W2087401867 countsByYear W20874018672017 @default.
• W2087401867 countsByYear W20874018672018 @default.
• W2087401867 countsByYear W20874018672019 @default.
• W2087401867 countsByYear W20874018672020 @default.
• W2087401867 countsByYear W20874018672021 @default.
• W2087401867 countsByYear W20874018672023 @default.
• W2087401867 crossrefType "journal-article" @default.
• W2087401867 hasAuthorship W2087401867A5011324497 @default.
• W2087401867 hasAuthorship W2087401867A5014470968 @default.
• W2087401867 hasAuthorship W2087401867A5024754671 @default.
• W2087401867 hasAuthorship W2087401867A5047762877 @default.
• W2087401867 hasAuthorship W2087401867A5063105876 @default.
• W2087401867 hasAuthorship W2087401867A5069821756 @default.
• W2087401867 hasAuthorship W2087401867A5083004906 @default.
• W2087401867 hasConcept C142724271 @default.
• W2087401867 hasConcept C169760540 @default.
• W2087401867 hasConcept C190283241 @default.
• W2087401867 hasConcept C207001950 @default.
• W2087401867 hasConcept C2776925932 @default.
• W2087401867 hasConcept C2779134260 @default.
• W2087401867 hasConcept C2779715522 @default.
• W2087401867 hasConcept C31573885 @default.
• W2087401867 hasConcept C529278444 @default.
• W2087401867 hasConcept C54355233 @default.
• W2087401867 hasConcept C71924100 @default.
• W2087401867 hasConcept C86803240 @default.
• W2087401867 hasConcept C95444343 @default.
• W2087401867 hasConceptScore W2087401867C142724271 @default.
• W2087401867 hasConceptScore W2087401867C169760540 @default.
• W2087401867 hasConceptScore W2087401867C190283241 @default.

• next