Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087418773> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2087418773 endingPage "215" @default.
- W2087418773 startingPage "207" @default.
- W2087418773 abstract "Since several years, macromolecular micelles based on amphiphilic block copolymers have attracted much interest as drug carriers. These micelles show a long term blood circulation time resulting from their small diameter and the steric repulsion created by the poly(ethylene oxide) chains which constitute micelle corona, as well as from their high thermodynamic stability. Besides this long term blood circulation time generating a passive targeting, an active targeting, chemical or physical affinity targeting, might allow the preparation of more efficient drug carriers. In order to obtain such double targeting properties, we have prepared two kinds of macromolecular micelles. The first one is based on amphiphilic poly(ethylene oxide)/poly(β-benzyl l-aspartate) PEO/PBLA block copolymers having hydroxy groups at the free end of PEO chains. As a result of their structure, such micelles have hydroxy groups on their outer-shell which can be further modified in order to introduce a targeting moiety (sugar, etc.). The characteristics (diameter, critical micellar concentration (cmc), drug loading capacity) have been determined. Moreover, doxorubicin loaded α-hydroxy PEO/PBLA micelles have been shown to be slightly more cytotoxic than the corresponding α-methoxy PEO/PBLA micelles. The second type of micelles is based on thermosensitive amphiphilic poly(N-isopropyl acrylamide)/polystyrene PIPAAm/PSt block copolymers. Such micelles have a small diameter and a low cmc in addition to thermosensitivity properties which are similar to those of PIPAAm." @default.
- W2087418773 created "2016-06-24" @default.
- W2087418773 creator A5015097923 @default.
- W2087418773 creator A5021216695 @default.
- W2087418773 creator A5046565682 @default.
- W2087418773 date "1999-11-01" @default.
- W2087418773 modified "2023-10-15" @default.
- W2087418773 title "Functional and site-specific macromolecular micelles as high potential drug carriers" @default.
- W2087418773 cites W148863560 @default.
- W2087418773 cites W1495785845 @default.
- W2087418773 cites W1502144912 @default.
- W2087418773 cites W1634023372 @default.
- W2087418773 cites W1925665128 @default.
- W2087418773 cites W1968139774 @default.
- W2087418773 cites W1980522922 @default.
- W2087418773 cites W1982218431 @default.
- W2087418773 cites W2029760712 @default.
- W2087418773 cites W2053336786 @default.
- W2087418773 cites W2061106944 @default.
- W2087418773 cites W2063393437 @default.
- W2087418773 cites W2065422398 @default.
- W2087418773 cites W2072289689 @default.
- W2087418773 cites W2078534751 @default.
- W2087418773 cites W2080464257 @default.
- W2087418773 cites W2090234450 @default.
- W2087418773 cites W2092700187 @default.
- W2087418773 cites W2109828871 @default.
- W2087418773 cites W24101640 @default.
- W2087418773 doi "https://doi.org/10.1016/s0927-7765(99)00071-5" @default.
- W2087418773 hasPublicationYear "1999" @default.
- W2087418773 type Work @default.
- W2087418773 sameAs 2087418773 @default.
- W2087418773 citedByCount "47" @default.
- W2087418773 countsByYear W20874187732012 @default.
- W2087418773 countsByYear W20874187732013 @default.
- W2087418773 countsByYear W20874187732014 @default.
- W2087418773 countsByYear W20874187732015 @default.
- W2087418773 countsByYear W20874187732016 @default.
- W2087418773 countsByYear W20874187732017 @default.
- W2087418773 countsByYear W20874187732020 @default.
- W2087418773 countsByYear W20874187732021 @default.
- W2087418773 crossrefType "journal-article" @default.
- W2087418773 hasAuthorship W2087418773A5015097923 @default.
- W2087418773 hasAuthorship W2087418773A5021216695 @default.
- W2087418773 hasAuthorship W2087418773A5046565682 @default.
- W2087418773 hasConcept C11268172 @default.
- W2087418773 hasConcept C127413603 @default.
- W2087418773 hasConcept C13245373 @default.
- W2087418773 hasConcept C15920480 @default.
- W2087418773 hasConcept C178790620 @default.
- W2087418773 hasConcept C184651966 @default.
- W2087418773 hasConcept C185592680 @default.
- W2087418773 hasConcept C188027245 @default.
- W2087418773 hasConcept C192562407 @default.
- W2087418773 hasConcept C204389451 @default.
- W2087418773 hasConcept C2777801237 @default.
- W2087418773 hasConcept C2779820397 @default.
- W2087418773 hasConcept C42360764 @default.
- W2087418773 hasConcept C521977710 @default.
- W2087418773 hasConcept C55493867 @default.
- W2087418773 hasConcept C64237528 @default.
- W2087418773 hasConcept C67407626 @default.
- W2087418773 hasConceptScore W2087418773C11268172 @default.
- W2087418773 hasConceptScore W2087418773C127413603 @default.
- W2087418773 hasConceptScore W2087418773C13245373 @default.
- W2087418773 hasConceptScore W2087418773C15920480 @default.
- W2087418773 hasConceptScore W2087418773C178790620 @default.
- W2087418773 hasConceptScore W2087418773C184651966 @default.
- W2087418773 hasConceptScore W2087418773C185592680 @default.
- W2087418773 hasConceptScore W2087418773C188027245 @default.
- W2087418773 hasConceptScore W2087418773C192562407 @default.
- W2087418773 hasConceptScore W2087418773C204389451 @default.
- W2087418773 hasConceptScore W2087418773C2777801237 @default.
- W2087418773 hasConceptScore W2087418773C2779820397 @default.
- W2087418773 hasConceptScore W2087418773C42360764 @default.
- W2087418773 hasConceptScore W2087418773C521977710 @default.
- W2087418773 hasConceptScore W2087418773C55493867 @default.
- W2087418773 hasConceptScore W2087418773C64237528 @default.
- W2087418773 hasConceptScore W2087418773C67407626 @default.
- W2087418773 hasIssue "1-4" @default.
- W2087418773 hasLocation W20874187731 @default.
- W2087418773 hasOpenAccess W2087418773 @default.
- W2087418773 hasPrimaryLocation W20874187731 @default.
- W2087418773 hasRelatedWork W1846316342 @default.
- W2087418773 hasRelatedWork W1964725291 @default.
- W2087418773 hasRelatedWork W1984670152 @default.
- W2087418773 hasRelatedWork W1990749808 @default.
- W2087418773 hasRelatedWork W2044014390 @default.
- W2087418773 hasRelatedWork W2046424700 @default.
- W2087418773 hasRelatedWork W2058348134 @default.
- W2087418773 hasRelatedWork W2084455369 @default.
- W2087418773 hasRelatedWork W3206494524 @default.
- W2087418773 hasRelatedWork W4210447090 @default.
- W2087418773 hasVolume "16" @default.
- W2087418773 isParatext "false" @default.
- W2087418773 isRetracted "false" @default.
- W2087418773 magId "2087418773" @default.
- W2087418773 workType "article" @default.