FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087419529> ?p ?o ?g. }

• W2087419529 endingPage "578" @default.
• W2087419529 startingPage "572" @default.
• W2087419529 abstract "Boophane disticha of the family Amaryllidaceae is used traditionally in southern Africa in the treatment of several neurological disorders. Although acetylcholinesterase (AChE) inhibitory activity has been reported for this plant, the aim of the study was to identify and characterise the compound responsible for this activity using bioassay guided fractionation. Toxicity of the isolated compound was also assessed. Bioassay guided isolation of the active compound from the methanol extract was carried out using column chromatography, TLC and preparative thin layer chromatography. Structural elucidation was carried out using high field 1D and 2D NMR and mass spectroscopy. AChE inhibitory activity was determined using the Ellman’s colorimetric method. Cytotoxicity assessment was determined in human neuroblastoma (SH-SY5Y) cells using the MTT and neutral red uptake assays. The data obtained from the integration of the 1H spectra confirmed the compound to be a 3:1 mixture of two epimers, with epimer A, 6α-hydroxycrinamine as the major epimer. The IC50 value for AChE inhibitory activity of the compound was 445 μM. The compound was observed to be cytotoxic in both the MTT and neutral red assays with IC50 values of 54.5 and 61.7 μM, respectively. The present study describes for the first time, the isolation of 6-hydroxycrinamine, a crinine alkaloid, from the methanol extract of the bulbs of B. disticha. Although this compound possessed AChE inhibitory activity, it was found to be toxic to the neuroblastoma cells. Quantitative structure–activity relationship studies could be carried out to modify the structure in order to make it less toxic and improve its activity." @default.
• W2087419529 created "2016-06-24" @default.
• W2087419529 creator A5034651641 @default.
• W2087419529 creator A5052539190 @default.
• W2087419529 creator A5087640636 @default.
• W2087419529 date "2012-09-01" @default.
• W2087419529 modified "2023-09-24" @default.
• W2087419529 title "Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae)" @default.
• W2087419529 cites W1958334384 @default.
• W2087419529 cites W1964095432 @default.
• W2087419529 cites W1964277164 @default.
• W2087419529 cites W1971513938 @default.
• W2087419529 cites W1972465273 @default.
• W2087419529 cites W1974367106 @default.
• W2087419529 cites W1980773820 @default.
• W2087419529 cites W2006656242 @default.
• W2087419529 cites W2010818369 @default.
• W2087419529 cites W2012671411 @default.
• W2087419529 cites W2018738988 @default.
• W2087419529 cites W2020168054 @default.
• W2087419529 cites W2038059465 @default.
• W2087419529 cites W2038061915 @default.
• W2087419529 cites W2044255919 @default.
• W2087419529 cites W2045837086 @default.
• W2087419529 cites W2049261214 @default.
• W2087419529 cites W2049860537 @default.
• W2087419529 cites W2053450061 @default.
• W2087419529 cites W2054526986 @default.
• W2087419529 cites W2062720541 @default.
• W2087419529 cites W2072355219 @default.
• W2087419529 cites W2079977910 @default.
• W2087419529 cites W2084319449 @default.
• W2087419529 cites W2093995463 @default.
• W2087419529 cites W2114918609 @default.
• W2087419529 cites W2137777161 @default.
• W2087419529 cites W2141339944 @default.
• W2087419529 cites W2155087576 @default.
• W2087419529 cites W2168480444 @default.
• W2087419529 cites W2274811202 @default.
• W2087419529 cites W2325194233 @default.
• W2087419529 doi "https://doi.org/10.1016/j.jep.2012.07.011" @default.
• W2087419529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22835813" @default.
• W2087419529 hasPublicationYear "2012" @default.
• W2087419529 type Work @default.
• W2087419529 sameAs 2087419529 @default.
• W2087419529 citedByCount "42" @default.
• W2087419529 countsByYear W20874195292012 @default.
• W2087419529 countsByYear W20874195292013 @default.
• W2087419529 countsByYear W20874195292014 @default.
• W2087419529 countsByYear W20874195292015 @default.
• W2087419529 countsByYear W20874195292016 @default.
• W2087419529 countsByYear W20874195292017 @default.
• W2087419529 countsByYear W20874195292018 @default.
• W2087419529 countsByYear W20874195292019 @default.
• W2087419529 countsByYear W20874195292020 @default.
• W2087419529 countsByYear W20874195292021 @default.
• W2087419529 countsByYear W20874195292022 @default.
• W2087419529 countsByYear W20874195292023 @default.
• W2087419529 crossrefType "journal-article" @default.
• W2087419529 hasAuthorship W2087419529A5034651641 @default.
• W2087419529 hasAuthorship W2087419529A5052539190 @default.
• W2087419529 hasAuthorship W2087419529A5087640636 @default.
• W2087419529 hasBestOaLocation W20874195292 @default.
• W2087419529 hasConcept C104488531 @default.
• W2087419529 hasConcept C109316439 @default.
• W2087419529 hasConcept C181199279 @default.
• W2087419529 hasConcept C185592680 @default.
• W2087419529 hasConcept C190196608 @default.
• W2087419529 hasConcept C202751555 @default.
• W2087419529 hasConcept C203130289 @default.
• W2087419529 hasConcept C2777667214 @default.
• W2087419529 hasConcept C2778105851 @default.
• W2087419529 hasConcept C2778816929 @default.
• W2087419529 hasConcept C2780783641 @default.
• W2087419529 hasConcept C43617362 @default.
• W2087419529 hasConcept C54355233 @default.
• W2087419529 hasConcept C55493867 @default.
• W2087419529 hasConcept C59822182 @default.
• W2087419529 hasConcept C71240020 @default.
• W2087419529 hasConcept C86803240 @default.
• W2087419529 hasConceptScore W2087419529C104488531 @default.
• W2087419529 hasConceptScore W2087419529C109316439 @default.
• W2087419529 hasConceptScore W2087419529C181199279 @default.
• W2087419529 hasConceptScore W2087419529C185592680 @default.
• W2087419529 hasConceptScore W2087419529C190196608 @default.
• W2087419529 hasConceptScore W2087419529C202751555 @default.
• W2087419529 hasConceptScore W2087419529C203130289 @default.
• W2087419529 hasConceptScore W2087419529C2777667214 @default.
• W2087419529 hasConceptScore W2087419529C2778105851 @default.
• W2087419529 hasConceptScore W2087419529C2778816929 @default.
• W2087419529 hasConceptScore W2087419529C2780783641 @default.
• W2087419529 hasConceptScore W2087419529C43617362 @default.
• W2087419529 hasConceptScore W2087419529C54355233 @default.
• W2087419529 hasConceptScore W2087419529C55493867 @default.
• W2087419529 hasConceptScore W2087419529C59822182 @default.
• W2087419529 hasConceptScore W2087419529C71240020 @default.
• W2087419529 hasConceptScore W2087419529C86803240 @default.
• W2087419529 hasIssue "2" @default.

• next