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- W2087426238 abstract "A new reversed-phase high-performance liquid chromatographic method allowing simultaneous measurement of plasma concentrations of disopyramide and quinidine is described. Disopyramide and quinidine were separated on a reversed-phase column using 0.05 M phosphate buffer (pH 3.0)--acetonitrile (73:27, v/v), as mobile phase and the peaks were monitored by UV absorbance at the wavelengths of 254 and 325 nm. The drugs were extracted from alkaline plasma with chloroform containing the internal standard. The organic phase was evaporated to dryness and the residue was redissolved in a small volume of the mobile phase before analysis by high-performance liquid chromatography. The method is convenient and reliable in routine monitoring of both drugs." @default.
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- W2087426238 date "1980-07-01" @default.
- W2087426238 modified "2023-09-27" @default.
- W2087426238 title "Simultaneous analysis of disopyramide and quinidine in plasma by high-performance liquid chromatography" @default.
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- W2087426238 doi "https://doi.org/10.1016/s0378-4347(00)81399-7" @default.
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