Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087431046> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2087431046 endingPage "127" @default.
- W2087431046 startingPage "119" @default.
- W2087431046 abstract "A novel precolumn derivatization method for the HPLC determination of cytosine-containing compounds by HPLC is described. Highly fluorescent 2-phenyl-3,N4-ethenocytosine derivatives are produced by a reaction of non-fluorescent cytosine-containing compounds with phenacyl bromide in weakly acidic acetonitrile solution at elevated temperature. The applicability of the method to various biogenic and antiviral compounds is demonstrated. Quantitative determination of cidofovir, a potent antiviral drug currently undergoing evaluation in the clinic for treatment of cytomegalovirus retinitis is also reported. The limit of detection for cidofovir in cynomolgus monkey plasma was 5 ng/ml (ca. 100 fmol on column) with the between-day precision of 16.6, 6.4 and 2.4% for five replicate samples at 20, 160 and 320 ng/ml, respectively. The within-day precision was 15.9, 5.9 and 2.1%, respectively. The method described has broad applicability and may offer significant advantages over existing HPLC methods in antiviral drug development as well as in nucleic acid research." @default.
- W2087431046 created "2016-06-24" @default.
- W2087431046 creator A5022520313 @default.
- W2087431046 creator A5072785251 @default.
- W2087431046 date "1996-04-01" @default.
- W2087431046 modified "2023-09-26" @default.
- W2087431046 title "High-performance liquid chromatographic determination of cytosine-containing compounds by precolumn fluorescence derivatization with phenacyl bromide: application to antiviral nucleosides and nucleotides" @default.
- W2087431046 cites W1501171104 @default.
- W2087431046 cites W1840621144 @default.
- W2087431046 cites W1964102386 @default.
- W2087431046 cites W1981023048 @default.
- W2087431046 cites W2007913357 @default.
- W2087431046 cites W2009310796 @default.
- W2087431046 cites W2051075314 @default.
- W2087431046 cites W2066206076 @default.
- W2087431046 cites W2091248843 @default.
- W2087431046 cites W2093600697 @default.
- W2087431046 doi "https://doi.org/10.1016/0378-4347(95)00585-4" @default.
- W2087431046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8998550" @default.
- W2087431046 hasPublicationYear "1996" @default.
- W2087431046 type Work @default.
- W2087431046 sameAs 2087431046 @default.
- W2087431046 citedByCount "24" @default.
- W2087431046 countsByYear W20874310462012 @default.
- W2087431046 countsByYear W20874310462014 @default.
- W2087431046 countsByYear W20874310462021 @default.
- W2087431046 crossrefType "journal-article" @default.
- W2087431046 hasAuthorship W2087431046A5022520313 @default.
- W2087431046 hasAuthorship W2087431046A5072785251 @default.
- W2087431046 hasConcept C104317684 @default.
- W2087431046 hasConcept C119128265 @default.
- W2087431046 hasConcept C121332964 @default.
- W2087431046 hasConcept C159047783 @default.
- W2087431046 hasConcept C178790620 @default.
- W2087431046 hasConcept C179998833 @default.
- W2087431046 hasConcept C185592680 @default.
- W2087431046 hasConcept C2522874641 @default.
- W2087431046 hasConcept C2776023528 @default.
- W2087431046 hasConcept C2776300020 @default.
- W2087431046 hasConcept C2776824251 @default.
- W2087431046 hasConcept C2776923573 @default.
- W2087431046 hasConcept C2778324468 @default.
- W2087431046 hasConcept C40875361 @default.
- W2087431046 hasConcept C43617362 @default.
- W2087431046 hasConcept C512185932 @default.
- W2087431046 hasConcept C552990157 @default.
- W2087431046 hasConcept C55493867 @default.
- W2087431046 hasConcept C62520636 @default.
- W2087431046 hasConcept C86803240 @default.
- W2087431046 hasConcept C91881484 @default.
- W2087431046 hasConceptScore W2087431046C104317684 @default.
- W2087431046 hasConceptScore W2087431046C119128265 @default.
- W2087431046 hasConceptScore W2087431046C121332964 @default.
- W2087431046 hasConceptScore W2087431046C159047783 @default.
- W2087431046 hasConceptScore W2087431046C178790620 @default.
- W2087431046 hasConceptScore W2087431046C179998833 @default.
- W2087431046 hasConceptScore W2087431046C185592680 @default.
- W2087431046 hasConceptScore W2087431046C2522874641 @default.
- W2087431046 hasConceptScore W2087431046C2776023528 @default.
- W2087431046 hasConceptScore W2087431046C2776300020 @default.
- W2087431046 hasConceptScore W2087431046C2776824251 @default.
- W2087431046 hasConceptScore W2087431046C2776923573 @default.
- W2087431046 hasConceptScore W2087431046C2778324468 @default.
- W2087431046 hasConceptScore W2087431046C40875361 @default.
- W2087431046 hasConceptScore W2087431046C43617362 @default.
- W2087431046 hasConceptScore W2087431046C512185932 @default.
- W2087431046 hasConceptScore W2087431046C552990157 @default.
- W2087431046 hasConceptScore W2087431046C55493867 @default.
- W2087431046 hasConceptScore W2087431046C62520636 @default.
- W2087431046 hasConceptScore W2087431046C86803240 @default.
- W2087431046 hasConceptScore W2087431046C91881484 @default.
- W2087431046 hasIssue "1-2" @default.
- W2087431046 hasLocation W20874310461 @default.
- W2087431046 hasLocation W20874310462 @default.
- W2087431046 hasOpenAccess W2087431046 @default.
- W2087431046 hasPrimaryLocation W20874310461 @default.
- W2087431046 hasRelatedWork W1968781128 @default.
- W2087431046 hasRelatedWork W1976198411 @default.
- W2087431046 hasRelatedWork W2008937680 @default.
- W2087431046 hasRelatedWork W2026578023 @default.
- W2087431046 hasRelatedWork W2036255866 @default.
- W2087431046 hasRelatedWork W2071445639 @default.
- W2087431046 hasRelatedWork W2074239113 @default.
- W2087431046 hasRelatedWork W2084062459 @default.
- W2087431046 hasRelatedWork W2089074688 @default.
- W2087431046 hasRelatedWork W2096641431 @default.
- W2087431046 hasVolume "679" @default.
- W2087431046 isParatext "false" @default.
- W2087431046 isRetracted "false" @default.
- W2087431046 magId "2087431046" @default.
- W2087431046 workType "article" @default.