Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087431623> ?p ?o ?g. }
- W2087431623 endingPage "209" @default.
- W2087431623 startingPage "203" @default.
- W2087431623 abstract "Memory deficits associated with aging and Alzheimer's disease have been linked to cholinergic dysfunction. The present study investigated this hypothesis by comparing the effects of the muscarinic cholinergic receptor antagonist scopolamine on recent memory performance and by examining muscarinic receptor density in aged and young dogs. Scopolamine (15 μg/kg; SC) was administered prior to testing young (M = 2.8 years) and aged (M = 13.0 years) dogs on a delayed-non-matching-to-position task (DNMP). Scopolamine significantly impaired performance of aged, but not young dogs. Muscarinic receptor density was assessed autoradiographically using the non-selective radioligand [3H]quinuclidinylbenzilate. Aged dogs (M = 14.1 years) showed significantly decreased density of muscarinic receptors in all brain regions examined except the cerebellum compared to young dogs (M = 3.7 years). The results are consistent with those seen in aged humans and Alzheimer's patients and support the hypothesis of age-dependent cholinergic dysfunction in the dog, although this was not directly determined in the current study. These findings demonstrate that markers of cholinergic hypofunction, in addition to the natural cognitive decline and amyloid pathology previously noted, are seen in canine aging. Collectively, this supports the use of the aged dog as a model for examining early pathological events in the development of Alzheimer's disease." @default.
- W2087431623 created "2016-06-24" @default.
- W2087431623 creator A5040517151 @default.
- W2087431623 creator A5041767246 @default.
- W2087431623 creator A5051450477 @default.
- W2087431623 creator A5066936294 @default.
- W2087431623 date "2011-04-01" @default.
- W2087431623 modified "2023-10-16" @default.
- W2087431623 title "Aged dogs demonstrate both increased sensitivity to scopolamine impairment and decreased muscarinic receptor density" @default.
- W2087431623 cites W1521900586 @default.
- W2087431623 cites W1606587171 @default.
- W2087431623 cites W1675018259 @default.
- W2087431623 cites W1751585141 @default.
- W2087431623 cites W1783307413 @default.
- W2087431623 cites W1964698997 @default.
- W2087431623 cites W1965868118 @default.
- W2087431623 cites W1969383277 @default.
- W2087431623 cites W1972736369 @default.
- W2087431623 cites W1974010226 @default.
- W2087431623 cites W1982064952 @default.
- W2087431623 cites W1982612223 @default.
- W2087431623 cites W1985060949 @default.
- W2087431623 cites W1986329493 @default.
- W2087431623 cites W1987482425 @default.
- W2087431623 cites W1992268087 @default.
- W2087431623 cites W1994067502 @default.
- W2087431623 cites W1999657277 @default.
- W2087431623 cites W2004713321 @default.
- W2087431623 cites W2014495825 @default.
- W2087431623 cites W2014817579 @default.
- W2087431623 cites W2015413262 @default.
- W2087431623 cites W2016341445 @default.
- W2087431623 cites W2017485473 @default.
- W2087431623 cites W2018751883 @default.
- W2087431623 cites W2019654201 @default.
- W2087431623 cites W2020138720 @default.
- W2087431623 cites W2024722910 @default.
- W2087431623 cites W2026745182 @default.
- W2087431623 cites W2035189475 @default.
- W2087431623 cites W2037651109 @default.
- W2087431623 cites W2039626033 @default.
- W2087431623 cites W2043922259 @default.
- W2087431623 cites W2045197448 @default.
- W2087431623 cites W2052300068 @default.
- W2087431623 cites W2052613003 @default.
- W2087431623 cites W2052903119 @default.
- W2087431623 cites W2053363857 @default.
- W2087431623 cites W2055440612 @default.
- W2087431623 cites W2056798802 @default.
- W2087431623 cites W2060372151 @default.
- W2087431623 cites W2061664301 @default.
- W2087431623 cites W2065100984 @default.
- W2087431623 cites W2075680994 @default.
- W2087431623 cites W2079533377 @default.
- W2087431623 cites W2084504542 @default.
- W2087431623 cites W2087050159 @default.
- W2087431623 cites W2088073224 @default.
- W2087431623 cites W2088354687 @default.
- W2087431623 cites W2094516650 @default.
- W2087431623 cites W2101190997 @default.
- W2087431623 cites W2103440561 @default.
- W2087431623 cites W2103895975 @default.
- W2087431623 cites W2104227586 @default.
- W2087431623 cites W2108307256 @default.
- W2087431623 cites W2111493525 @default.
- W2087431623 cites W2114490924 @default.
- W2087431623 cites W2119268123 @default.
- W2087431623 cites W2127156102 @default.
- W2087431623 cites W2133779850 @default.
- W2087431623 cites W2137240494 @default.
- W2087431623 cites W2148779716 @default.
- W2087431623 cites W2150843918 @default.
- W2087431623 cites W2160033789 @default.
- W2087431623 cites W2161019904 @default.
- W2087431623 cites W2161400520 @default.
- W2087431623 cites W2162653297 @default.
- W2087431623 cites W4230373222 @default.
- W2087431623 cites W4241650885 @default.
- W2087431623 cites W4256116157 @default.
- W2087431623 cites W45982646 @default.
- W2087431623 doi "https://doi.org/10.1016/j.pbb.2011.01.005" @default.
- W2087431623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21238475" @default.
- W2087431623 hasPublicationYear "2011" @default.
- W2087431623 type Work @default.
- W2087431623 sameAs 2087431623 @default.
- W2087431623 citedByCount "20" @default.
- W2087431623 countsByYear W20874316232012 @default.
- W2087431623 countsByYear W20874316232013 @default.
- W2087431623 countsByYear W20874316232014 @default.
- W2087431623 countsByYear W20874316232015 @default.
- W2087431623 countsByYear W20874316232016 @default.
- W2087431623 countsByYear W20874316232017 @default.
- W2087431623 countsByYear W20874316232019 @default.
- W2087431623 countsByYear W20874316232021 @default.
- W2087431623 countsByYear W20874316232022 @default.
- W2087431623 crossrefType "journal-article" @default.
- W2087431623 hasAuthorship W2087431623A5040517151 @default.
- W2087431623 hasAuthorship W2087431623A5041767246 @default.