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• W2087446502 abstract "A novel series of benzimidazolone-containing histamine H 3 -receptor antagonists were prepared and their structure–activity relationship was explored. These benzimidazolone analogs demonstrate potent H 3 -receptor binding affinities, no P450 enzyme inhibition, and strong H 3 functional activity. Compound 1o exhibits the best overall profile with H 3 K i = 0.95 nM and rat AUC = 12.9 μM h." @default.
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• W2087446502 date "2013-11-01" @default.
• W2087446502 modified "2023-09-24" @default.
• W2087446502 title "Synthesis and SAR studies of benzimidazolone derivatives as histamine H3-receptor antagonists" @default.
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• W2087446502 doi "https://doi.org/10.1016/j.bmcl.2013.08.012" @default.
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