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- W2087452023 abstract "To solve the problem of localization of the active center of cytochrome P-450 in microsomal membranes, new bifunctional compounds (I–IV), which contain pyridine radical, aliphatic chain of variable length and diphosphonic acid (“floating” molecules) have been applied. These compounds inhibit oxidation and binding of the substrates of cytochrome P-450 (aminopyrine and aniline), inhibition being of a competitive character. Measurements of distribution coefficients between water and membranes of microsomes and liposomes from egg phosphatidylcholine evidence that the microsomal proteins are necessary for providing effective interaction of I–IV with microsomal membrane. The 1H-NMR method has demonstrated compounds to be incorporated into lipid bilayer so that the non-polar part is in the inner membrane volume. The results obtained confirm our previous conclusion (Krainev A.G., Weiner L.M., Alferyev I.S., Slynko N.M. (1985) Biochim. Biophys. Acta, 818, 96–104) about localization of the active center of microsomal cytochrome P-450 at the depth of ∼ 18 Å from the hydrophilic surface of a membrane." @default.
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- W2087452023 date "1977-05-01" @default.
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- W2087452023 title "Binding of barbiturates to hepatic microsomes of the rat" @default.
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- W2087452023 doi "https://doi.org/10.1016/0006-2952(77)90481-6" @default.
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