Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087466867> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2087466867 endingPage "164" @default.
- W2087466867 startingPage "157" @default.
- W2087466867 abstract "There is a requirement to deliver accurate amounts of broad spectrum antimicrobial compounds locally to exuding wounds. Varying amounts of exudate complicates this process by limiting the residence and therefore efficacy of active substances. Minimum bactericidal concentrations (MBC) of antimicrobials are necessary to suppress infection and lessen the chances of resistant strains of potentially pathogenic bacteria from prevailing. Polysaccharide wafers can adhere to exudating wound beds, absorbing fluids and forming highly viscous gels that remain in situ for prolonged periods of time to release sustained amounts of antimicrobial. In this study, five different formulations were produced containing the antimicrobial, chlorhexidine digluconate (CHD). Absorption of simulated wound fluid, resultant rheological properties of gels and efficacy against plated cultures of Pseudomonas aeruginosa were measured and compared. CHD reduced the ‘water uptake’ of wafers by 11–50% (w/w) and decreased the rheological consistency of non-SA containing gels by 10–65%. Release studies indicated that karaya wafers gave the highest sustained release of CHD, >60 μg/mL in 24 h, well in excess of the MBC for P. aeruginosa. Release kinetics indicated an anomalous diffusion mechanism according to Korsmeyer–Peppas, with diffusion exponents varying from 0.31 to 0.41 for most wafers except xanthan (0.65)." @default.
- W2087466867 created "2016-06-24" @default.
- W2087466867 creator A5017300658 @default.
- W2087466867 creator A5029163679 @default.
- W2087466867 creator A5065069236 @default.
- W2087466867 date "2012-12-01" @default.
- W2087466867 modified "2023-09-26" @default.
- W2087466867 title "Lyophilised wafers as vehicles for the topical release of chlorhexidine digluconate—Release kinetics and efficacy against Pseudomonas aeruginosa" @default.
- W2087466867 cites W1967716496 @default.
- W2087466867 cites W1972573571 @default.
- W2087466867 cites W1987312039 @default.
- W2087466867 cites W2004328494 @default.
- W2087466867 cites W2009841111 @default.
- W2087466867 cites W2010345433 @default.
- W2087466867 cites W2012237893 @default.
- W2087466867 cites W2017001941 @default.
- W2087466867 cites W2039249444 @default.
- W2087466867 cites W2039437191 @default.
- W2087466867 cites W2074936705 @default.
- W2087466867 cites W2083849720 @default.
- W2087466867 cites W2103909937 @default.
- W2087466867 cites W2165694975 @default.
- W2087466867 doi "https://doi.org/10.1016/j.ijpharm.2012.10.017" @default.
- W2087466867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23085374" @default.
- W2087466867 hasPublicationYear "2012" @default.
- W2087466867 type Work @default.
- W2087466867 sameAs 2087466867 @default.
- W2087466867 citedByCount "14" @default.
- W2087466867 countsByYear W20874668672013 @default.
- W2087466867 countsByYear W20874668672014 @default.
- W2087466867 countsByYear W20874668672015 @default.
- W2087466867 countsByYear W20874668672017 @default.
- W2087466867 countsByYear W20874668672018 @default.
- W2087466867 countsByYear W20874668672020 @default.
- W2087466867 countsByYear W20874668672023 @default.
- W2087466867 crossrefType "journal-article" @default.
- W2087466867 hasAuthorship W2087466867A5017300658 @default.
- W2087466867 hasAuthorship W2087466867A5029163679 @default.
- W2087466867 hasAuthorship W2087466867A5065069236 @default.
- W2087466867 hasConcept C121332964 @default.
- W2087466867 hasConcept C148898269 @default.
- W2087466867 hasConcept C178790620 @default.
- W2087466867 hasConcept C185592680 @default.
- W2087466867 hasConcept C199343813 @default.
- W2087466867 hasConcept C2777084678 @default.
- W2087466867 hasConcept C2777637488 @default.
- W2087466867 hasConcept C43617362 @default.
- W2087466867 hasConcept C4937899 @default.
- W2087466867 hasConcept C523546767 @default.
- W2087466867 hasConcept C54355233 @default.
- W2087466867 hasConcept C62520636 @default.
- W2087466867 hasConcept C69357855 @default.
- W2087466867 hasConcept C71924100 @default.
- W2087466867 hasConcept C86803240 @default.
- W2087466867 hasConcept C89423630 @default.
- W2087466867 hasConcept C97355855 @default.
- W2087466867 hasConceptScore W2087466867C121332964 @default.
- W2087466867 hasConceptScore W2087466867C148898269 @default.
- W2087466867 hasConceptScore W2087466867C178790620 @default.
- W2087466867 hasConceptScore W2087466867C185592680 @default.
- W2087466867 hasConceptScore W2087466867C199343813 @default.
- W2087466867 hasConceptScore W2087466867C2777084678 @default.
- W2087466867 hasConceptScore W2087466867C2777637488 @default.
- W2087466867 hasConceptScore W2087466867C43617362 @default.
- W2087466867 hasConceptScore W2087466867C4937899 @default.
- W2087466867 hasConceptScore W2087466867C523546767 @default.
- W2087466867 hasConceptScore W2087466867C54355233 @default.
- W2087466867 hasConceptScore W2087466867C62520636 @default.
- W2087466867 hasConceptScore W2087466867C69357855 @default.
- W2087466867 hasConceptScore W2087466867C71924100 @default.
- W2087466867 hasConceptScore W2087466867C86803240 @default.
- W2087466867 hasConceptScore W2087466867C89423630 @default.
- W2087466867 hasConceptScore W2087466867C97355855 @default.
- W2087466867 hasIssue "1-2" @default.
- W2087466867 hasLocation W20874668671 @default.
- W2087466867 hasLocation W20874668672 @default.
- W2087466867 hasOpenAccess W2087466867 @default.
- W2087466867 hasPrimaryLocation W20874668671 @default.
- W2087466867 hasRelatedWork W1608733658 @default.
- W2087466867 hasRelatedWork W1820852492 @default.
- W2087466867 hasRelatedWork W2396822601 @default.
- W2087466867 hasRelatedWork W2400380072 @default.
- W2087466867 hasRelatedWork W2473401431 @default.
- W2087466867 hasRelatedWork W2737643780 @default.
- W2087466867 hasRelatedWork W3001980293 @default.
- W2087466867 hasRelatedWork W3025605316 @default.
- W2087466867 hasRelatedWork W3046721888 @default.
- W2087466867 hasRelatedWork W3096215692 @default.
- W2087466867 hasVolume "439" @default.
- W2087466867 isParatext "false" @default.
- W2087466867 isRetracted "false" @default.
- W2087466867 magId "2087466867" @default.
- W2087466867 workType "article" @default.