Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087487745> ?p ?o ?g. }
- W2087487745 endingPage "909" @default.
- W2087487745 startingPage "899" @default.
- W2087487745 abstract "Allergic asthma is a chronic inflammatory disease of the airways characterized by excessive eosinophilic and lymphocytic inflammation with associated changes in the extracellular matrix (ECM) resulting in airway wall remodeling. Hyaluronan (HA) is a nonsulfated glycosaminoglycan ECM component that functions as a structural cushion in its high molecular mass (HMM) but has been implicated in metastasis and other disease processes when it is degraded to smaller fragments. However, relatively little is known about the role HA in mediating inflammatory responses in allergy and asthma. In the present study, we used a murine Aspergillus fumigatus inhalational model to mimic human disease. After observing in vivo that a robust B cell recruitment followed a massive eosinophilic egress to the lumen of the allergic lung and corresponded with the detection of low molecular mass HA (LMM HA), we examined the effect of HA on B cell chemotaxis and cytokine production in the ex vivo studies. We found that LMM HA functioned through a CD44-mediated mechanism to elicit chemotaxis of B lymphocytes, while high molecular mass HA (HMM HA) had little effect. LMM HA, but not HMM HA, also elicited the production of IL-10 and TGF-β1 in these cells. Taken together, these findings demonstrate a critical role for ECM components in mediating leukocyte migration and function which are critical to the maintenance of allergic inflammatory responses." @default.
- W2087487745 created "2016-06-24" @default.
- W2087487745 creator A5007838117 @default.
- W2087487745 creator A5029888161 @default.
- W2087487745 creator A5032831608 @default.
- W2087487745 creator A5060753885 @default.
- W2087487745 creator A5070008665 @default.
- W2087487745 creator A5078768906 @default.
- W2087487745 creator A5079150657 @default.
- W2087487745 date "2015-07-01" @default.
- W2087487745 modified "2023-10-18" @default.
- W2087487745 title "Hyaluronan stimulates ex vivo B lymphocyte chemotaxis and cytokine production in a murine model of fungal allergic asthma" @default.
- W2087487745 cites W108191710 @default.
- W2087487745 cites W1483144827 @default.
- W2087487745 cites W1577146075 @default.
- W2087487745 cites W1577893357 @default.
- W2087487745 cites W1593964246 @default.
- W2087487745 cites W1619959770 @default.
- W2087487745 cites W1774424307 @default.
- W2087487745 cites W1921991607 @default.
- W2087487745 cites W1955772849 @default.
- W2087487745 cites W1967852927 @default.
- W2087487745 cites W1969175063 @default.
- W2087487745 cites W1973463627 @default.
- W2087487745 cites W1981720291 @default.
- W2087487745 cites W1997450131 @default.
- W2087487745 cites W1998921946 @default.
- W2087487745 cites W2002221418 @default.
- W2087487745 cites W2002585892 @default.
- W2087487745 cites W2005318950 @default.
- W2087487745 cites W2008324333 @default.
- W2087487745 cites W2009034357 @default.
- W2087487745 cites W2010625755 @default.
- W2087487745 cites W2010880354 @default.
- W2087487745 cites W2013109174 @default.
- W2087487745 cites W2013849003 @default.
- W2087487745 cites W2015596970 @default.
- W2087487745 cites W2015808599 @default.
- W2087487745 cites W2016952830 @default.
- W2087487745 cites W2021423422 @default.
- W2087487745 cites W2023653155 @default.
- W2087487745 cites W2024754183 @default.
- W2087487745 cites W2025666606 @default.
- W2087487745 cites W2026112263 @default.
- W2087487745 cites W2028258199 @default.
- W2087487745 cites W2030295847 @default.
- W2087487745 cites W2037108578 @default.
- W2087487745 cites W2039356605 @default.
- W2087487745 cites W2040279779 @default.
- W2087487745 cites W2041483144 @default.
- W2087487745 cites W2047940554 @default.
- W2087487745 cites W2049426078 @default.
- W2087487745 cites W2050333516 @default.
- W2087487745 cites W2051563649 @default.
- W2087487745 cites W2053289663 @default.
- W2087487745 cites W2053802748 @default.
- W2087487745 cites W2053837765 @default.
- W2087487745 cites W2055195076 @default.
- W2087487745 cites W2061432699 @default.
- W2087487745 cites W2062264071 @default.
- W2087487745 cites W2064864417 @default.
- W2087487745 cites W2071113717 @default.
- W2087487745 cites W2075171560 @default.
- W2087487745 cites W2076384755 @default.
- W2087487745 cites W2077007440 @default.
- W2087487745 cites W2085004003 @default.
- W2087487745 cites W2088152324 @default.
- W2087487745 cites W2088225529 @default.
- W2087487745 cites W2088437016 @default.
- W2087487745 cites W2088719923 @default.
- W2087487745 cites W2089753996 @default.
- W2087487745 cites W2092938408 @default.
- W2087487745 cites W2093711396 @default.
- W2087487745 cites W2096350767 @default.
- W2087487745 cites W2097847761 @default.
- W2087487745 cites W2101837780 @default.
- W2087487745 cites W2104932984 @default.
- W2087487745 cites W2117370942 @default.
- W2087487745 cites W2117566184 @default.
- W2087487745 cites W2118295402 @default.
- W2087487745 cites W2127053176 @default.
- W2087487745 cites W2128098949 @default.
- W2087487745 cites W2129081579 @default.
- W2087487745 cites W2129520501 @default.
- W2087487745 cites W2129630239 @default.
- W2087487745 cites W2140988563 @default.
- W2087487745 cites W2141197648 @default.
- W2087487745 cites W2141416258 @default.
- W2087487745 cites W2145307509 @default.
- W2087487745 cites W2149192119 @default.
- W2087487745 cites W2153878821 @default.
- W2087487745 cites W2153911335 @default.
- W2087487745 cites W2154399487 @default.
- W2087487745 cites W2155894576 @default.
- W2087487745 cites W2160529853 @default.
- W2087487745 cites W2164021363 @default.
- W2087487745 cites W2164898284 @default.
- W2087487745 cites W2168329184 @default.