FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087488758> ?p ?o ?g. }

• W2087488758 abstract "Abstract Background Among the three functions of DNA, mammalian replication and transcription can be subject to epigenetic imprinting specified by the parental origin of chromosomes, and although there is suggestive indication that this is also true for meiotic recombination, no definitive evidence has yet been reported. Results We have now obtained such evidence on mouse chromosome 7 by assaying meiotic recombination as it occurs in reciprocal F1 mice. A 166 kb region near the Kcnq1 transcriptionally imprinted domain showed significantly higher recombination activity in the CAST×B6 parental direction (p < 0.03). Characterizing hotspots within this domain revealed a cluster of three hotspots lying within a 100 kb span, among these hotspots, Slc22a18 showed a definitive parent of origin effect on recombination frequency (p < 0.02). Comparing recombination activity in the mouse Kcnq1 and neighboring H19-Igf2 imprinted domains with their human counterparts, we found that elevated recombination activity in these domains is a consequence of their chromosomal position relative to the telomere and not an intrinsic characteristic of transcriptionally imprinted domains as has been previously suggested. Conclusion Similar to replication and transcription, we demonstrate that meiotic recombination can be subjected to epigenetic imprinting and hotspot activity can be influenced by the parental origin of chromosomes. Furthermore, transcriptionally imprinted regions exhibiting elevated recombination activity are likely a consequence of their chromosomal location rather than their transcriptional characteristic." @default.
• W2087488758 created "2016-06-24" @default.
• W2087488758 creator A5023502395 @default.
• W2087488758 creator A5035753337 @default.
• W2087488758 creator A5056976753 @default.
• W2087488758 creator A5057952036 @default.
• W2087488758 creator A5062860507 @default.
• W2087488758 creator A5071509189 @default.
• W2087488758 date "2009-05-13" @default.
• W2087488758 modified "2023-09-26" @default.
• W2087488758 title "Parental origin of chromosomes influences crossover activity within the Kcnq1 transcriptionally imprinted domain of Mus musculus" @default.
• W2087488758 cites W1973619926 @default.
• W2087488758 cites W1974164983 @default.
• W2087488758 cites W1976695083 @default.
• W2087488758 cites W1977481227 @default.
• W2087488758 cites W1987882116 @default.
• W2087488758 cites W2004457665 @default.
• W2087488758 cites W2005942028 @default.
• W2087488758 cites W2008787085 @default.
• W2087488758 cites W2009844552 @default.
• W2087488758 cites W2015649315 @default.
• W2087488758 cites W2018217952 @default.
• W2087488758 cites W2022736814 @default.
• W2087488758 cites W2031586320 @default.
• W2087488758 cites W2035736579 @default.
• W2087488758 cites W2038263304 @default.
• W2087488758 cites W2044611683 @default.
• W2087488758 cites W2061980400 @default.
• W2087488758 cites W2075805514 @default.
• W2087488758 cites W2079915982 @default.
• W2087488758 cites W2092463855 @default.
• W2087488758 cites W2107964125 @default.
• W2087488758 cites W2111398277 @default.
• W2087488758 cites W2124429706 @default.
• W2087488758 cites W2129987350 @default.
• W2087488758 cites W2133339852 @default.
• W2087488758 cites W2139763312 @default.
• W2087488758 cites W2155069081 @default.
• W2087488758 cites W2165172234 @default.
• W2087488758 cites W2169628131 @default.
• W2087488758 cites W2408758330 @default.
• W2087488758 doi "https://doi.org/10.1186/1471-2199-10-43" @default.
• W2087488758 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2689222" @default.
• W2087488758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19439080" @default.
• W2087488758 hasPublicationYear "2009" @default.
• W2087488758 type Work @default.
• W2087488758 sameAs 2087488758 @default.
• W2087488758 citedByCount "8" @default.
• W2087488758 countsByYear W20874887582012 @default.
• W2087488758 countsByYear W20874887582016 @default.
• W2087488758 crossrefType "journal-article" @default.
• W2087488758 hasAuthorship W2087488758A5023502395 @default.
• W2087488758 hasAuthorship W2087488758A5035753337 @default.
• W2087488758 hasAuthorship W2087488758A5056976753 @default.
• W2087488758 hasAuthorship W2087488758A5057952036 @default.
• W2087488758 hasAuthorship W2087488758A5062860507 @default.
• W2087488758 hasAuthorship W2087488758A5071509189 @default.
• W2087488758 hasBestOaLocation W20874887581 @default.
• W2087488758 hasConcept C102744134 @default.
• W2087488758 hasConcept C104317684 @default.
• W2087488758 hasConcept C138885662 @default.
• W2087488758 hasConcept C148196450 @default.
• W2087488758 hasConcept C150194340 @default.
• W2087488758 hasConcept C156695909 @default.
• W2087488758 hasConcept C177336024 @default.
• W2087488758 hasConcept C179926584 @default.
• W2087488758 hasConcept C190727270 @default.
• W2087488758 hasConcept C201492766 @default.
• W2087488758 hasConcept C41091548 @default.
• W2087488758 hasConcept C41895202 @default.
• W2087488758 hasConcept C54355233 @default.
• W2087488758 hasConcept C552990157 @default.
• W2087488758 hasConcept C86803240 @default.
• W2087488758 hasConcept C94715292 @default.
• W2087488758 hasConceptScore W2087488758C102744134 @default.
• W2087488758 hasConceptScore W2087488758C104317684 @default.
• W2087488758 hasConceptScore W2087488758C138885662 @default.
• W2087488758 hasConceptScore W2087488758C148196450 @default.
• W2087488758 hasConceptScore W2087488758C150194340 @default.
• W2087488758 hasConceptScore W2087488758C156695909 @default.
• W2087488758 hasConceptScore W2087488758C177336024 @default.
• W2087488758 hasConceptScore W2087488758C179926584 @default.
• W2087488758 hasConceptScore W2087488758C190727270 @default.
• W2087488758 hasConceptScore W2087488758C201492766 @default.
• W2087488758 hasConceptScore W2087488758C41091548 @default.
• W2087488758 hasConceptScore W2087488758C41895202 @default.
• W2087488758 hasConceptScore W2087488758C54355233 @default.
• W2087488758 hasConceptScore W2087488758C552990157 @default.
• W2087488758 hasConceptScore W2087488758C86803240 @default.
• W2087488758 hasConceptScore W2087488758C94715292 @default.
• W2087488758 hasIssue "1" @default.
• W2087488758 hasLocation W20874887581 @default.
• W2087488758 hasLocation W20874887582 @default.
• W2087488758 hasLocation W20874887583 @default.
• W2087488758 hasLocation W20874887584 @default.
• W2087488758 hasOpenAccess W2087488758 @default.
• W2087488758 hasPrimaryLocation W20874887581 @default.
• W2087488758 hasRelatedWork W1973277595 @default.
• W2087488758 hasRelatedWork W1973619926 @default.
• W2087488758 hasRelatedWork W1977481227 @default.

• next