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- W2087489067 abstract "Purpose of review This review examines changes instituted in stem cell transplantation that may improve transplant outcomes by optimizing the effects of the conditioning regimen without increasing toxicity. Recent findings Significant improvements have been achieved in progenitor cell transplantation that will enhance long-term disease control rates, diminish toxicity, increase access to transplantation, and provide the optimal treatment intensity for each patient. Among the most notable of these developments are the following. First, an intravenous formulation of busulfan (one of the most commonly used agents for transplant conditioning) has been developed. It has been shown to be associated with less toxicity, and its therapeutic efficacy may be further increased by pharmacokinetic monitoring. Second, cyclophosphamide may be replaced by fludarabine, both in the ablative and reduced intensity settings. Third, targeted therapies have been incorporated into conditioning regimens, particularly monoclonal antibodies such as rituximab and alemtuzumab. Finally, comorbidity scoring systems have been developed that can predict whether severe toxicities will develop, therefore allowing the conditioning regimen to be better tailored to the patient. Summary New advances in stem cell transplantation promise improved transplant outcomes with less morbidity." @default.
- W2087489067 created "2016-06-24" @default.
- W2087489067 creator A5070096873 @default.
- W2087489067 date "2006-02-01" @default.
- W2087489067 modified "2023-09-27" @default.
- W2087489067 title "Optimizing conditioning regimens for autologous and allogeneic progenitor cell transplantation" @default.
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- W2087489067 doi "https://doi.org/10.1097/01.mot.0000209294.02783.5c" @default.
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