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- W2087490091 abstract "Morpholine oleic acid salt (MOAS) was administered to groups of 50 male and 50 female B6C3F1 mice in the drinking-water at levels of 0, 0.25 and 1.0%. Both sexes given 1.0% MOAS and females given 0.25% showed growth retardation. Significant increases in blood-urea nitrogen concentrations were only observed in the 1.0% male group. The incidence of squamous-cell hyperplasia of the forestomach epithelium was significantly higher in the males given 1.0% than in the controls. The male mice given 0.25% MOAS had a significantly reduced incidence of hepatocellular carcinoma in comparison with the control group and this trend was indicated also in the 1.0% group. This experiment did not demonstrate any carcinogenic effect of MOAS in mice at levels up to 1.0% in the drinking-water." @default.
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- W2087490091 date "1987-08-01" @default.
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- W2087490091 title "Combined chronic toxicity and carcinogenicity studies of morpholine oleic acid salt in B6C3F1 mice" @default.
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- W2087490091 doi "https://doi.org/10.1016/0278-6915(87)90016-0" @default.
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