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• W2087494093 abstract "<b><i>Aims:</i></b> Although varenicline is commonly prescribed in primary care, information on smoking-related comorbidities and the effectiveness of varenicline in this context in Germany is scarce. This study assessed the efficacy and safety of varenicline in a large sample of patients seeking smoking cessation treatment through their general practitioners. The frequency of comorbidities was also evaluated. <b><i>Methods:</i></b> This was a 12-week, prospective, observational, non-comparative phase IV trial conducted in Germany. Abstinence rates at week 12 were evaluated by verbal reporting using the nicotine use inventory. <b><i>Results:</i></b> Overall, 1,391 subjects were enrolled; 1,177 received study medication and were evaluated for effectiveness and safety. At the end of the study, 71.1% (95% confidence interval 68.5–73.7) of subjects were abstinent. There were a total of 205 all-causality adverse events; 2.2% were classified as serious or severe. There were no fatal adverse events. At inclusion, 66.7% of participants had at least 1 concurrent comorbidity, with chronic obstructive pulmonary disease (35.5%), hypertension (29.6%) and depression (10.4%) being the most commonly reported. <b><i>Conclusion:</i></b> These real-world data indicate that varenicline is an effective and well-tolerated smoking cessation treatment when used in the primary care setting including patients with smoking-related comorbidities." @default.
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• W2087494093 date "2012-09-14" @default.
• W2087494093 modified "2023-09-26" @default.
• W2087494093 title "Effectiveness of Varenicline as an Aid to Smoking Cessation in Primary Care: An Observational Study" @default.
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• W2087494093 doi "https://doi.org/10.1159/000341638" @default.
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