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- W2087494300 abstract "A dose of 6.5 mg/kg mescaline which acutely abolishes fixed-ratio appetitive responding in pigeons becomes progressively less disruptive with repeated administration. When responding reaches about 60% of baseline (in about 3 weeks) no further tolerance occurs. A dose of 3.5 mg/kg mescaline acutely lowers responding to about 60% of baseline and repeated administration of this dose continues to produce approximately the same response deficit. Discontinuation of both doses results in an immediate return to baseline levels of responding. Two possible mechanisms underlying this two-stage action of mescaline seen in this and other studies are discussed. The endogenous hallucinogen hypothesis of schizophrenia is considered in light of the existence of tolerance-resistant hallucinogenic drug effects." @default.
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- W2087494300 date "1976-07-01" @default.
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- W2087494300 title "The effects of chronic mescaline administration on operant behavior in the pigeon" @default.
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- W2087494300 doi "https://doi.org/10.1016/s0091-6773(76)90766-5" @default.
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